Research output per year
Research output per year
- 1 - 50 out of 662 results
Search results
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2024
Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis
Liang, P., Zhang, Y., Wan, Y. C. S., Ma, S., Dong, P., Lowry, A. J., Francis, S. J., Khandelwal, S., Delahunty, M., Telen, M. J., Strouse, J. J., Arepally, G. M. & Yang, H., Jan 25 2024, In: Blood. 143, 4, p. 357-369 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila
Zhang, S., Wu, S., Yao, R., Wei, X., Ohlstein, B. & Guo, Z., Jan 8 2024, In: Developmental cell. 59, 1, p. 125-140.e12Research output: Contribution to journal › Article › peer-review
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Glutamine antagonists may KEAP lung cancer in check
Blatt, E. B. & DeBerardinis, R. J., Mar 2024, In: Science Advances. 10, 13, eado7808.Research output: Contribution to journal › Article › peer-review
Open Access -
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
Deja, S., Fletcher, J., Kim, C-W., Kucejova, B., Fu, X., Mizerska, M., Villegas, M., Pudelko-Malik, N., Browder, N., Inigo-Vollmer, M., Menezes, C. J., Mishra, P., Berglund, E. D., Browning, J. D., Thyfault, J. P., Young, J. D., Horton, J. D. & Burgess, S. C., 2024, (Accepted/In press) In: Cell Metabolism.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Metabolic signatures of thymomas: potential biomarkers and treatment targets
Miller, J. W., Faubert, B. M., Mathews, T. P., Waters, J. K., DeBerardinis, R. J. & Kernstine, K. H., Feb 1 2024, In: European Journal of Cardio-thoracic Surgery. 65, 2, ezad394.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Schistosome Infection Impacts Hematopoiesis
Wijshake, T., Rose, J., Wang, J., Zielke, J., Marlar-Pave, M., Chen, W., Collins, J. J. & Agathocleous, M., Feb 1 2024, In: Journal of Immunology. 212, 4, p. 607-616 10 p.Research output: Contribution to journal › Article › peer-review
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Severely polarized extracellular acidity around tumour cells
Feng, Q., Bennett, Z., Grichuk, A., Pantoja, R., Huang, T., Faubert, B., Huang, G., Chen, M., DeBerardinis, R. J., Sumer, B. D. & Gao, J., 2024, (Accepted/In press) In: Nature Biomedical Engineering.Research output: Contribution to journal › Article › peer-review
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2023
A comparative study of neuroendocrine heterogeneity in small cell lung cancer and neuroblastoma
Cai, L., De Berardinis, R. J., Xie, Y., Minna, J. D. & Xiao, G., Aug 1 2023, In: Molecular Cancer Research. 21, 8, p. 795-807 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A concurrent dual analysis of genomic data augments diagnoses: Experiences of 2 clinical sites in the Undiagnosed Diseases Network
Undiagnosed Diseases Network & Undiagnosed Diseases Network, Apr 2023, In: Genetics in Medicine. 25, 4, 100353.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis
Mukherjee, A., Bezwada, D., Greco, F., Zandbergen, M., Shen, T., Chiang, C. Y., Tasdemir, M., Fahrmann, J., Grapov, D., La Frano, M. R., Vu, H. S., Faubert, B., Newman, J. W., McDonnell, L. A., Nezi, L., Fiehn, O., DeBerardinis, R. J. & Lengyel, E., Sep 2023, In: Nature Metabolism. 5, 9, p. 1563-1577 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut
Wu, S., Tang, R., Ohlstein, B. & Guo, Z., Dec 15 2023, In: STAR Protocols. 4, 4, 102749.Research output: Contribution to journal › Article › peer-review
Open Access -
Bi-allelic variants in INTS11 are associated with a complex neurological disorder
Undiagnosed Diseases Network, May 4 2023, In: American Journal of Human Genetics. 110, 5, p. 774-789 16 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Biallelic variants in NUDCD2 associated with a multiple malformation syndrome with cholestasis and renal failure
Scheuerle, A. E., Ni, M., Ahmad, A. A., Timmons, C. F., Rakheja, D., Gordon, E. E. & Boothe, M., Sep 2023, In: American Journal of Medical Genetics, Part A. 191, 9, p. 2324-2328 5 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy
Undiagnosed Diseases Network, Sep 2023, In: Genetics in Medicine. 25, 9, 100897.Research output: Contribution to journal › Article › peer-review
Open Access -
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples
Cai, F., Bezwada, D., Cai, L., Mahar, R., Wu, Z., Chang, M. C., Pachnis, P., Yang, C., Kelekar, S., Gu, W., Brooks, B., Ko, B., Vu, H. S., Mathews, T. P., Zacharias, L. G., Martin-Sandoval, M., Do, D., Oaxaca, K. C., Jin, E. S., Margulis, V., & 3 others, Oct 3 2023, In: Cell Metabolism. 35, 10, p. 1830-1843.e5Research output: Contribution to journal › Article › peer-review
Open Access -
Continuing a search for a diagnosis: the impact of adolescence and family dynamics
Undiagnosed Disease Network, Dec 2023, In: Orphanet Journal of Rare Diseases. 18, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Critical role of antioxidant programs in enzalutamide-resistant prostate cancer
Blatt, E. B., Parra, K., Neeb, A., Buroni, L., Bogdan, D., Yuan, W., Gao, Y., Gilbreath, C., Paschalis, A., Carreira, S., DeBerardinis, R. J., Mani, R. S., de Bono, J. S. & Raj, G. V., Jul 21 2023, In: Oncogene. 42, 30, p. 2347-2359 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images
Wen, Z., Lin, Y. H., Wang, S., Fujiwara, N., Rong, R., Jin, K. W., Yang, D. M., Yao, B., Yang, S., Wang, T., Xie, Y., Hoshida, Y., Zhu, H. & Xiao, G., Apr 2023, In: Genes. 14, 4, 921.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
De novo missense variants in phosphatidylinositol kinase PIP5KIγ underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling
Undiagnosed Diseases Network & Telethon Undiagnosed Diseases Program, Aug 3 2023, In: American Journal of Human Genetics. 110, 8, p. 1377-1393 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features
Undiagnosed Diseases Network, Jun 2023, In: Genetics in Medicine. 25, 6, 100833.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
Lyu, J., Liu, Y., Gong, L., Chen, M., Madanat, Y. F., Zhang, Y., Cai, F., Gu, Z., Cao, H., Kaphle, P., Kim, Y. J., Kalkan, F. N., Stephens, H., Dickerson, K. E., Ni, M., Chen, W., Patel, P., Mims, A. S., Borate, U., Burd, A., & 8 others, Jan 9 2023, In: Cancer discovery. 13, 1, p. 170-193 24 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Dissecting molecular, pathological, and clinical features associated with tumor neural/neuroendocrine heterogeneity
Cai, L., DeBerardinis, R. J., Xiao, G., Minna, J. D. & Xie, Y., Jun 16 2023, In: iScience. 26, 6, 106983.Research output: Contribution to journal › Article › peer-review
Open Access -
Dominant-negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome
University of Washington Center for Mendelian Genomics (UW-CMG), Undiagnosed Diseases Network (UDN), Jun 2023, In: Annals of Clinical and Translational Neurology. 10, 6, p. 1046-1053 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow
Kara, N., Xue, Y., Zhao, Z., Murphy, M. M., Comazzetto, S., Lesser, A., Du, L. & Morrison, S. J., Mar 13 2023, In: Developmental cell. 58, 5, p. 348-360.e6Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan
Ahmed, S., Akbar, F., Deberardinis, R. J., Ni, M. & Afroze, B., Aug 1 2023, In: Journal of Pediatric Endocrinology and Metabolism. 36, 8, p. 761-771 11 p.Research output: Contribution to journal › Article › peer-review
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Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Luebeck, J., Ng, A. W. T., Galipeau, P. C., Li, X., Sanchez, C. A., Katz-Summercorn, A. C., Kim, H., Jammula, S., He, Y., Lippman, S. M., Verhaak, R. G. W., Maley, C. C., Alexandrov, L. B., Reid, B. J., Fitzgerald, R. C., Paulson, T. G., Chang, H. Y., Wu, S., Bafna, V. & Mischel, P. S., Apr 27 2023, In: Nature. 616, 7958, p. 798-805 8 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
Dai, W., Wang, Z., Wang, G., Wang, Q. A., DeBerardinis, R. & Jiang, L., Aug 29 2023, In: Cell Reports. 42, 8, 112971.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms
Ahmed, M. S., Farag, A. B., Boys, I. N., Wang, P., Menendez-Montes, I., Nguyen, N. U. N., Eitson, J. L., Ohlson, M. B., Fan, W., McDougal, M. B., Mar, K., Thet, S., Ortiz, F., Kim, S. Y., Solmonson, A., Williams, N. S., Lemoff, A., DeBerardinis, R. J., Schoggins, J. W. & Sadek, H. A., Jun 2023, In: Biomedicine and Pharmacotherapy. 162, 114614.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer
Wang, S., Rong, R., Yang, D. M., Fujimoto, J., Bishop, J. A., Yan, S., Cai, L., Behrens, C., Berry, L. D., Wilhelm, C., Aisner, D., Sholl, L., Johnson, B. E., Kwiatkowski, D. J., Wistuba, I. I., Bunn, P. A., Minna, J., Xiao, G., Kris, M. G. & Xie, Y., Jan 17 2023, In: Journal of Clinical Investigation. 133, 2, e160330.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers
Huffman, K. E., Li, L. S., Carstens, R., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R., Timmons, B., Sudderth, J., Bendris, N., Kim, J., Villalobos, P., Fujimoto, J., Schmid, S., Deberardinis, R. J., Wistuba, I., Heymach, J., Kittler, R., Akbay, E. A., & 6 others, 2023, In: Frontiers in Oncology. 13, 1025443.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing
Yu, D. M., Zhao, J., Lee, E. E., Kim, D., Mahapatra, R., Rose, E. K., Zhou, Z., Hosler, C., El Kurdi, A., Choe, J. Y., Abel, E. D., Hoxhaj, G., Westover, K. D., Cho, R. J., Cheng, J. B. & Wang, R. C., Nov 1 2023, In: Journal of Clinical Investigation. 133, 21, e170706.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells
Ikeda, M., Kato, H., Shima, H., Matsumoto, M., Furukawa, E., Yan, Y., Liao, R., Xu, J., Muto, A., Fujiwara, T., Harigae, H., Bresnick, E. H. & Igarashi, K., Feb 2023, In: Experimental Hematology. 118, p. 21-30 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder
Genomics England Research Consortium & Undiagnosed Diseases Network, Aug 3 2023, In: American Journal of Human Genetics. 110, 8, p. 1414-1435 22 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration
Lin, Y. H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M. H., Corbitt, N., Zhang, Y., Sharma, T., Wang, T. & Zhu, H., May 4 2023, In: Cell Stem Cell. 30, 5, p. 665-676.e4Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
Nawas, A. F., Solmonson, A., Gao, B., DeBerardinis, R. J., Minna, J. D., Conacci-Sorrell, M. & Mendelson, C. R., Dec 2023, In: Cell Communication and Signaling. 21, 1, 331.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System
Rong, R., Wei, Y., Li, L., Wang, T., Zhu, H., Xiao, G. & Wang, Y., Aug 2023, In: EBioMedicine. 94, 104698.Research output: Contribution to journal › Article › peer-review
Open Access -
Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions
Miller, J. J., Gonzalez Castro, L. N., McBrayer, S., Weller, M., Cloughesy, T., Portnow, J., Andronesi, O., Barnholtz-Sloan, J. S., Baumert, B. G., Berger, M. S., Bi, W. L., Bindra, R., Cahill, D. P., Chang, S. M., Costello, J. F., Horbinski, C., Huang, R. Y., Jenkins, R. B., Ligon, K. L., Mellinghoff, I. K., & 11 others, Jan 5 2023, In: Neuro-oncology. 25, 1, p. 4-25 22 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Itaconate-producing neutrophils regulate local and systemic inflammation following trauma
Crossley, J. L., Ostashevskaya-Gohstand, S., Comazzetto, S., Hook, J. S., Guo, L., Vishlaghi, N., Juan, C., Xu, L., Horswill, A. R., Hoxhaj, G., Moreland, J. G., Tower, R. J. & Levi, B., Oct 2023, In: JCI Insight. 8, 20, e169208.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
L-2-hydroxyglutaric aciduria – review of literature and case series
Ahmed, S., Siddiqui, A., DeBerardinis, R. J., Ni, M., Lai, W. G., Cai, F., Vu, H. S. & Afroze, B., Apr 1 2023, In: Annals of Medicine and Surgery. 85, 4, p. 712-717 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Lactate metabolism is essential in early-onset mitochondrial myopathy
Chen, Z., Bordieanu, B., Kesavan, R., Lesner, N. P., Venigalla, S. S. K., Shelton, S. D., DeBerardinis, R. J. & Mishra, P., Jan 2023, In: Science Advances. 9, 1, eadd3216.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
Gao, X., Murphy, M. M., Peyer, J. G., Ni, Y., Yang, M., Zhang, Y., Guo, J., Kara, N., Embree, C., Tasdogan, A., Ubellacker, J. M., Crane, G. M., Fang, S., Zhao, Z., Shen, B. & Morrison, S. J., Dec 2023, In: Nature cell biology. 25, 12, p. 1746-1757 12 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions
Kim, Y. J., Lee, M., Lee, Y. T., Jing, J., Sanders, J. T., Botten, G. A., He, L., Lyu, J., Zhang, Y., Mettlen, M., Ly, P., Zhou, Y. & Xu, J., Mar 29 2023, In: Science Advances. 9, 13, eadg1123.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
Parida, P. K., Marquez-Palencia, M., Ghosh, S., Khandelwal, N., Kim, K., Nair, V., Liu, X. Z., Vu, H. S., Zacharias, L. G., Gonzalez-Ericsson, P. I., Sanders, M. E., Mobley, B. C., McDonald, J. G., Lemoff, A., Peng, Y., Lewis, C., Vale, G., Halberg, N., Arteaga, C. L., Hanker, A. B., & 2 others, Jun 2023, In: Nature Cancer. 4, 6, p. 893-907 15 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
Qian, Y., Galan-Cobo, A., Guijarro, I., Dang, M., Molkentine, D., Poteete, A., Zhang, F., Wang, Q., Wang, J., Parra, E., Panda, A., Fang, J., Skoulidis, F., Wistuba, I. I., Verma, S., Merghoub, T., Wolchok, J. D., Wong, K. K., DeBerardinis, R. J., Minna, J. D., & 6 others, Jul 10 2023, In: Cancer Cell. 41, 7, p. 1363-1380.e7Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, J., Rosales, T., Ko, B., Campos-Sandoval, J. A., Alonso, F. J., Márquez, J., DeBerardinis, R. J. & Matés, J. M., Jan 2023, In: Cancers. 15, 2, 531.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-Type glioblastoma
Richardson, T. E., Yokoda, R. T., Rashidipour, O., Vij, M., Snuderl, M., Brem, S., Hatanpaa, K. J., McBrayer, S. K., Abdullah, K. G., Umphlett, M., Walker, J. M. & Tsankova, N. M., Jan 1 2023, In: Neuro-Oncology Advances. 5, 1, vdad085.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid
Frank, A. R., Li, V., Shelton, S. D., Kim, J., Stott, G. M., Neckers, L. M., Xie, Y., Williams, N. S., Mishra, P. & McFadden, D. G., Aug 1 2023, In: Cancer discovery. 13, 8, p. 1884-1903 20 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation
Li, Y., Hook, J. S., Ding, Q., Xiao, X., Chung, S. S., Mettlen, M., Xu, L., Moreland, J. G. & Agathocleous, M., Dec 2023, In: Nature communications. 14, 1, 2610.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo
Ocaña, M. C., Bernal, M., Yang, C., Caro, C., Domínguez, A., Vu, H. S., Cárdenas, C., García-Martín, M. L., DeBerardinis, R. J., Quesada, A. R., Martínez-Poveda, B. & Medina, M. Á., Dec 2023, In: Communications Biology. 6, 1, 1084.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel pathogenic UQCRC2 variants in a female with normal neurodevelopment
Haidar, L. A., Harris, R. C., Pachnis, P., Chen, H., Gotway, G. K., Ni, M. & DeBerardinis, R. J., 2023, In: Cold Spring Harbor Molecular Case Studies. 9, 4Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations