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  • 2011

    Targeted therapies for lung cancer: Clinical experience and novel agents

    Larsen, J. E., Cascone, T., Gerber, D. E., Heymach, J. V. & Minna, J. D., Nov 2011, In: Cancer Journal. 17, 6, p. 512-527 16 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    93 Scopus citations

  • Targeting mutant p53 protein and the tumor vasculature: An effective combination therapy for advanced breast tumors

    Liang, Y., Besch-Williford, C., Benakanakere, I., Thorpe, P. E. & Hyder, S. M., Jan 2011, In: Breast Cancer Research and Treatment. 125, 2, p. 407-420 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    23 Scopus citations

  • TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

    Ou, Y. H., Torres, M., Ram, R., Formstecher, E., Roland, C., Cheng, T., Brekken, R., Wurz, R., Tasker, A., Polverino, T., Tan, S. L. & White, M. A., Feb 18 2011, In: Molecular cell. 41, 4, p. 458-470 13 p.

    Research output: Contribution to journal › Article › peer-review

    181 Scopus citations

  • Temporal competition between differentiation programs determines cell fate choice

    Kuchina, A., Espinar, L., Çaǧatay, T., Balbin, A. O., Zhang, F., Alvarado, A., Garcia-Ojalvo, J. & Süel, G. M., 2011, In: Molecular Systems Biology. 7, 557.

    Research output: Contribution to journal › Article › peer-review

    64 Scopus citations

  • TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy

    Peña-Llopis, S. & Brugarolas, J., Dec 1 2011, In: Cell Cycle. 10, 23, p. 3987-3988 2 p.

    Research output: Contribution to journal › Editorial › peer-review

    Open Access
    31 Scopus citations

  • The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus

    Williams, K. W., Sohn, J. W., Donato, J., Lee, C. E., Zhao, J. J., Elmquist, J. K. & Elias, C. F., Sep 14 2011, In: Journal of Neuroscience. 31, 37, p. 13147-13156 10 p.

    Research output: Contribution to journal › Article › peer-review

    64 Scopus citations

  • The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse

    DeFord-Watts, L. M., Dougall, D. S., Belkaya, S., Johnson, B. A., Eitson, J. L., Roybal, K. T., Barylko, B., Albanesi, J. P., Wülfing, C. & Van Oers, N. S. C., Jun 15 2011, In: Journal of Immunology. 186, 12, p. 6839-6847 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    66 Scopus citations

  • The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors

    Li, W., Ma, C., Guan, R., Xu, Y., Tomchick, D. R. & Rizo-Rey, J., Oct 12 2011, In: Structure. 19, 10, p. 1443-1455 13 p.

    Research output: Contribution to journal › Article › peer-review

    68 Scopus citations

  • The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

    Li, T., Holmstrom, S. R., Kir, S., Umetani, M., Schmidt, D. R., Kliewer, S. A. & Mangelsdorf, D. J., Jun 2011, In: Molecular Endocrinology. 25, 6, p. 1066-1071 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    210 Scopus citations

  • The hedgehog-induced smoothened conformational switch assembles a signaling complex that activates fused by promoting its dimerization and phosphorylation

    Shi, Q., Li, S., Jia, J. & Jiang, J., Oct 1 2011, In: Development. 138, 19, p. 4219-4231 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Scopus citations

  • The national lung screening trial: Overview and study design

    Gatsonis, C. A., Aberle, D. R., Berg, C. D., Black, W. C., Church, T. R., Fagerstrom, R. M., Galen, B., Gareen, I. F., Goldin, J., Gohagan, J. K., Hillman, B., Jaffe, C., Kramer, B. S., Lynch, D., Marcus, P. M., Schnall, M., Sullivan, D. C., Sullivan, D., Zylak, C. J., Cagnon, C., & 1,319 othersCody, D., Fletcher, G., Flynn, M. J., Judy, P. F., Kruger, R., Larke, F. J., McNitt-Gray, M., Payne, T., Anthony Seibert, J., Wu, X., Abbott, G., Amorosa, J. K., Barr, R. G., Boiselle, P. M., Chiles, C., Clark, R., Coppage, L., Falk, R., Fishman, E. K., Gemmel, D., Goldin, J. G., Goodman, E., Hart, E. M., Hazelton, T., Johnson, E., Kazerooni, E., McComb, B., McLennan, G., Munden, R. F., Ravenel, J., Sullivan, M., Swensen, S. J., Torigian, D. A., Vydareny, K. H., Worrell, J. A., Balkin, P., Fouad, M., Freedman, M. T., Garg, K., Gelmann, E. P., Gierada, D. S., Hocking, W., Inampudi, S., Isaacs, C., Kvale, P., Mann, H., Manor, W., Nath, H., Reding, D., Spizarny, D. L., Strollo, D. C., Waltz, J., Chen, M. H., Duan, F., Izmirilian, G., Pinsky, P., Prorok, P. C., Miller, A. B., Edelman, M. J., Evans, W. K., Fontana, R. S., Machtay, M., Clark, K. W., Clingan, K. L., Ford, M. B., Márquez, G., Moore, S. M., Ohan, P., Payne, T. J., Peace, S., Rosenbaum, J. L., Barr, R., Black, W., Torigian, D., Vydareny, K., Worrell, J., Young, R. C., Alberts, D., DeMets, D., Greenwald, P., Jacobs, P., McLoud, T. C., Naidich, D. P., Tatum, J., Sausville, E. A., Burke, W., Colice, G., Edwards, B., Emerson, S., Fletcher, J., Green, S., Harris, R., Klein, J. S., Korn, E. L., Mayer, R., Selby, J. V., Sturges, D. W., Turnbull, B. W., Watson, T. J., Baylin, S., Caporaso, N., Dennis, P., Dubinett, S., Franklin, W., Grizzle, W., Hirsch, F., Massion, P., McKeeta-Frobeck, K., Minna, J., Patz, E., Spitz, M., Berg, C. B., Corle, D., Hu, P., Izmirlian, G., Gaegler, J., Hoffman, S., Jackson, C., Lange, E., Papadopoulos, E., Gatsonis, C., Gareen, I., Apgar, C., Boyle, A., Caldwell, T., Fredericks, N., Harbison, D., Hartfeil, D., Jones, S., King, S., Mahon, I., Medina, R., Masiejczyk, C., Zamora, P., Brastater, H., Iyer, V., George, J., Gopalakrishnan, D., Blair, P., Bradley, M., Crozier, C., Oh, M., Spiese, N., Steward, C., Kelly-Truran, M., Thompson, T., Cunningham, E., Levering, A., McMurtrie, K., Nahill, M., Snowden, S., Smith, K., Wilton, F., Welsh, T., Welsh, R., Christie, W., Clabo, S., Clune, R., Cunningham, N., Downs, J., Dymond, L., Falcone, J., Harris, S., Harvey, P., Hill, J., Hill, L., Letizia, D., Looney, K., McGinley, H., Mean, A., Moore, M., Norton, R., Ortico, V., Sabina, S., Sole, R., Stetz, J., Ssali, A., Stubblefield, J., Taylor, T., White, S., Lu, B., Adams, A., Baum, S., Blevins, M., Fox, P., Girardi, V., Gorelick, J., Hunt, E., McMullen, Q., Meganathan, K., Rendas-Baum, R., Sicks, J. D., Snyder, B., Yeh, M., Duggan, M., Souza, C., Cahill, J., Brewer, B. K., O'Brien, B., Devereux, G., Fritz, M. S., Galbraith, M., Harkins, J., Keating, K. J., Midkiff, K., Singh, U., Zimmerman, T., Payte, N., Price, H., Caughman, C., Chanapatna, R., Florzyk, M., Lee, A., Morgan, A., Yang, J., Ellen Martinusen, L., McSwain, J., Rosario, R., Singh, J., DeBaugh, R. A., Campleman, S., Mesnard, M., Ragard, L., Lewis, T., Roberts, L. M., Narayanaswami, V., Ralda, V., Lake, W., Riley, T., Clapp, J. B., Austin, J., Irons, B., Xu, F. F., Jones, G. C., Young, M., Goodman, A., Kibic, C., Sheridan, P., Kadish, N., Moline, D., Phillips, R., Adkinson, M., Creed, D., DeCoste, T., Gembala, D., Hurst, S., King, E., Knowles, J., McBride, P., Pangburn, P., Preston, J., Stokes, K., Tesch, P., Wenmoth, S., Galocy, L., Mandley, D., Orvis, G., Dial, A., Clark, L., Cohen, L., Gerber, J., Jamis-Dow, C., Makariou, E., Smith, E., Garrett, A., McGuire, C., Neff, S., Riley, T., Cantrell, S., Marsh, G., Wray, C., Yondonsambuu, B., Giles, U., Ford, M., Brown, V., Evangelista, A. L., Hammond, T., Nickel, J., Brangan, M., Lee, M., Lin, C., Adkins, E., Armah, G., Blue, C., Cooke, V., Gray, N., Gustitis, M., Hawkins, L., Isaacs, G., Kim, M., King, M., Kumbalasiri, K., Laura, R., McDaniel, K., Mulugeta, A., Riley, L., Sorrell, S., Thomas, W., Woodard, L., Johnson, C. C., Tammemagi, M., Spizarny, D., Zylak, C., Flynn, M., Sen, G. J., Sankey, S., Schultz, L., Albertsen, K., Broski, K., Kucera, G., Poler, K., Spoutz-Ryan, C., Thomas, D., Griesemer, E., Kwit, B., Fantuz, P., McLellan, B., Simmons, D., Hafeez, Y., Maddy, N., Davis, L., Estell, R., Kozakowski, S., Rowe, J., Stanley, M., Zhang, X., Frebes, M. E., Paquette, M., Tecmire, M., Young, L., Greene, D., Hill, C., Young, K., Bellware, K., Bohn, K., Caird, N., Fink, H., Fiarman, S., Houston, M., Jolly, A., Krzeczkowski, C., Mack, C., Murray, L., Nanovski, A., Rempinski, D., Tumberlinson, H., William, D., Eldridge-Smith, E., Graves, V., Szabo, N., Crump, J., Kruger, R., Greenlee, R., Lappe, K., Multerer, D., Kriescher, D., Vieth, A., Wein, S., Fuehrer, D., Gjertson, C., Krebsbach, J., Kuhlka, C., Luttrop, K., Netzer, J., Wegner, J., Fischer, V., Mathiesen-Viergutz, K., Kofka, K., Jablonsky, N., Johnson, B., Kitchner, T., Mueller, L., Rueth, A., Wachholz, S., Bohman, K., Bruger, M., Kramer, K. R., Kuenhold, K., Mueller, C., Mueller, C., Multerer, L., Zahradka, S., Alkilidar, J., Bhattacharjee, N., Cangelosi, C., Carlson, R., Coppens, A., Cousins, M., Edelstein, B., Gerndt, K., Heffernon, J., Hinke, T., Hinson, M., Hutchins, L., Lieberman, K., Mulligan, G., Omoba, E., Risa, T., Sheflin, J., Swan, T., Warner, J., Williams, A., Yokochi, L., Adaniya, R., Glanz, K., Navin, J., Shambaugh, V., Tabrah, F., Willcox, B., Williams, P., He, Q., Jenkins, V., Bow, K., Tsukamoto, J., Hyun, S., Brown, E., Morrow, H., Stryker, K., Shiratori, H., Lau, P., Au, B., Francis, W., Bolan, L., Brooke, J., Calulot, M., Chun, V., Rabanal, K., Tani, J., Lewis, C., Morfit, J., Brunst, A., Turner, L., Hino, G., Chung, A., Elbon-Copp, C., Huynh, W., Johnson, M., Nakano, E., Villaruz, L., Fouad, M. N., Bailey, W. C., Garver, R., Brawner, D., Malcomb, I., Morgan, D., Sanders, P. C., Sandy, A., Schwartz, M., Singh, S., Dransfield, M., Higgins, D., Moore, A., Acemgil, A., Blake, T., Lee, J., Quattlebaum, S., Schach, J., Martin, T., Khatri, R., Gendi, W., Powell, B., Johnson, C., Sears, J., Jordan, S., Prayer, V., Walker, C., Johnson, M., Thompson, J., David Crawford, E., Bunn, P., Gamito, E., Ogden, S., Pretzel, S., Ramsay, L., Vaughn, C., Whiton, C., Sammons, D., Springhetti, L., Tenorio, S., Cadez, N., Laster, S., O'Donnell, C., Hughes, J., Livingston, J. G., Morrison, G., Moss, W., Mullennix, M., Peters, M., Sahin, H., Slear, M., Burek, M., Hill, C., Jewitt, E., Pena, R., Ordonez, E., Sammons, G., Hernandez, J., Reyes, A., Somoza, A., Oken, M., Bay, B., Edelman, K., Fox, T., Gaerte, S., Myra-Bloom, K., Plunkett, M., Olson, F., Rust, P., Schneider, L., Trombley, B., Vahey, T., Bangerter, A., David-Schlegel, T., DesMarais, D., Frederickson, S., Geisser, M., Portnov, N., Silverman, G., Stahan, F., Vuong, S., Watt, G., Woodside, J., Zirbes, A., Breer, S., Haselhuhn, C., Longden, C., Mueller, C., Rice, M., Warren, D., Collins, S., Levi, S., Manual, J., Matous, L., Olsson, P., Peterson, S., Rogers, C., Steele, M. L., Beckmann, P., Jurjans, L., Terrian, S., Fraki, S., Fronheiser, M., Heinrichs, L., Kirby, D., Seivert, J., Steinberg, C., Watry, M., Boyle, K., Burnside, A., Kiffmeyer, R., Mosiman, W., Bailey, A., Byrnes, P., Stark, L., Weston, M., Whistler, D., Cordes, J., Engelhard, D., Becker, J., Bradley, P., Fisher, J., McLaughlin, H., Mendez, A. M., Miller, D., Ronan, R., Siga, B., Weissfeld, J. L., Salerno, M. B., Schragin, J., Strollo, D., Warfel, T. E., Wolfe, P. W., Antico, D. A., Bee, M. T., Bittner, D. F., Corey, W. T., Hawkins, R. A., Herbick, W. T., Karwat, M. F., Leonard, K. J., Petrochko, C. N., Pickering, S. F., Smart, P. E., Walters, P. J., Zehner, J. A., Augustine, K., Misko, S., Richel, M., Riley, M. A., Warren, L., McDonough, K., Rozanok, B., Helms, J., Olson, P., Uttecht, S., Wirth, M., Atkins, R., Clement, L., Gurtner, D., Jones, L., Buys, S. S., Drosten, R., Murray, K., Nowers, K., Jenkins, P., Tripp, D., Herron, G., Van Stam, E., Varner, J., O'Toole, K., Olson, C., Omori, D., Andersen, A., Argyle, N., Avrin, J., Bacon, J., Broschinsky, M., Montalbo, C., Nolan, K., Randall, A., Schleip, K., Sheltra, S. J., Tischner, R., Toyn, C., Turner, K., Whittaker, B., Wicklander, E., Wolf, J., Baiton, C., Doi, B., Childs, J., Gren, L., Watson, D., Jones, T., Neilson, B., Ahumada, H., Bourija, H., Brown, C., Ferris, B., Hadfield, L., Hansen, K., Koford, J., Kopesec, S., Lloyd, A., Lofthouse, M., Matinkhah, S., May, V., Nichols, S., Nieves, A., Oviatt, M., Richardson, N., Rowley, A. L., Sandberg, E., Dave Scholl, S., Seguin, L., Shea, D., Smith, S., Street, P. A., Walters, M., Weiben, R., Wilcox, L., Zisumbo, R., Beck, T. M., Waltz, J. S., Ball, S., Burt, T. B., Daniel, E. N., DeMordaunt, Q. A., Fisher, M. T., Fuchs, M. A., Hubler, B. E., Jennings, C. J., Lane, R. H., Leymaster, C. E., Macey, L. C., Marx, S. V., Maxwell, J. R., Nelson, B. B., Fairbanks, J., Wohlers, B., Heinz, J., Berreth, K., Marshall, R., Brekke, J., Jones, K., Barrow, A., Bashford, D., Clot, B., Cook, T., Dobson, L., Hamilton-Foss, A., Hanson, W., Hyder, J. E., Lewis-Burke, C., Mitchell, S., Osterhout, M., Patella, K., Peterson, P., Schornak-Curtis, S., Sirianni, L., Stoller, L., Vigeant, K., Whistle, C., Yates, J., Andriole, G., Claire Anderson, D., Bhalla, S., Bierhals, A. J., Bronfman, J., Glazer, H. S., Gutierrez, F. R., Geisse, G., Kotner, L. M., Javidan-Nejad, C., Rezai, K., Sagel, S. S., Semenkovich, J. W., Siegel, M. J., Sorrel, D., Woodard, P. K., Engelhart, D., Haverman, R., Campbell, A., Gardner, V., Gherardini, D., Hoese, L., Holdener, R., Ledbetter, L., Nieters, P., Reiners, C., Wade, J., Wiseman, M., Rueweler, P., Williams, R., Chi, D., Budd, T., Webb, J., Stolin, C., Garrett, K., Fleming, E., Freesmeier, E., Frye, J., Graham, D., Kaemmerer, H., Nevilles, J., Taylor, K., Blaine, J., Clark, K., Gierada, D., Koppel, P., Maffitt, D., Moore, S., Molton, J., Phillips, S., Prior, F., Wolfsberger, M., Cosas, A., Kim, S., Kim, M., Liang, Y., Pilgram, T., Haas, A., Hartwell, D., Roeshe, D., Lowery, A., Meese, S., Naughton, K., Yoffie, R., Smith, K., Schwartzstein, R., Lin, P. J. P., Parritt, T. A., Grady, E. A., Damon, L., Gard, S., Griggs, R., Potemkin, A., Pollock, M. M., Clellan, S. M., Laron, M., Owens, T., Costello, P., Jacobson, F. L., Hunsaker, A. R., Spirn, P. W., Trotman-Bickenson, B., Christopoulos, V. E., Kazda, I. K., MacDougall, R. C., Walsh, A., Nawfel, R. D., Berger, R., Chan, P., Delano, M., Geiger, J., Krinopol, C., McGinnis, A. D., McLaughlin, A. M., Weatherby, R., Tung, G., Maineiro, M., Camara, L., Cobb, C., Foley, S., Morrell, E., Romano, D., Guillette, D., Smith, W., Aisner, J., Backer, M., Bramwitt, M., De Caravalho, V., Epstein, R., Joyce, P., Langenfeld, J. E., Reinert, A., Team, R., DeMarco, K., Lutzker, S., Musanti, R., Shiff, S., Wolfsohn, T., Hudak, C., Hugill, A., Furlong, M., Weslowsky, E., Carmen, S., Foster, D. L., Hansen, K., Pennetta, B., White, L. V., Tokarz, R., Trotta, M., Birofka, A., Kasales, C. J., Lewis, P. J., Weaver, J. B., Lenz, S. B., Barrett, A. C., Dauphinais, R., Heinz, J. R., Siemionko, M. K., Taplin, A., Wasson, L. S., DeAlmeida, L., Longacre, S., Meagher, K., Moser, C. M., Lawlor, J. K., O'Quinn, C., Krieger Black, N. E., Bradley, H. L., Bronson, J. K., Cosgrove, T., Haron, M. K., King, D., Mazuerk, P. M., O'Donnell, N. F., Pluta, D. J., Sackett, T. J., Turgeon, G. D., Albano, H., Bell, C., Bergen, J., Bizer, G., Carmichael, N. M., Cimis, C., Davis, S., DeAngelis, T., Fellows, G., Fenton, C., Ferola, J., Gankiewicz, N., Hastings, D., Howell, C., Johnson, M. E., Krisk, M., Lancor, H., Leary, C., LeBlanc, M., Leming, A., Leming, M., Mead, D., Milacek, M., Mood, J., Nordstrom, H., Palazzolo, C., Pierce, J., Remitz, R. P., Rider, J., Robbins, K. A., Sleasman, B., Spaulding, J., Vashel, C., Welch, A., White, L., Whitty, M., Williams, A. M., Karellas, A., Grayson, L., McCalister-Cross, C., Mesquita, S., Nguyen, A., Myers, L. N., Deaton, E., Maxfield, S., Thomas, K., Allen, P., Brooks, D., Chadwell, C., Couch, E., Devore, A., Flores, R., Francis, M., Landes, S., Mattingly, J., Oechsli, M., Pitino, B., Sams, S., Soukhanova, O., Bland, P., Bube, S., Hoffa, T., McElsain, B., Johnson, D., Francow, C., Johnson, S., Senn, P., Horton, K. M., Lawler, L. P., Bradford, L., Christensen, G., Bishop, J., Motley, L., Robertson, B., Stewart, R., Guzman, C., Blake, H. B., Bradford, H., Bradford, J., Burner, J., Kasecamp, J., Kaufmann, J. B., Kimball, D., Lewis, Z., Moesinger, S., Walsh, S., Taylor, K., Yung, R., Zeng, M., Gambill, G., Merrill, S., Mahesh, M., Johnson, E. A., Jolies, H. I., Kuzo, R. S., Morin, R. L., Abaya, R., Chewar, D., Shwarts, P., Allen, S., Manning, S., Awan, M. A. Z., Clinic, M., Jacksonville, Beagle, F. L., Cape, D., Zeiger, T., Amendolare, L., Bahr, N., Belyea, M., Berg, T., Burkhard, M., Cottrell, L., BeAngelis, K., Bvorak, M., Heather, L., Gay, B., Hatton, K., Jacoby, S., Kennedy, V., Krach, K., Laughren, M., Lavergne, C., Lawrence, M., Lynch, J., McDonald, A., Mestas, F., Moody, J., O'Brien, C., Pitts, J., Polding, B., Richardson, L., Robinson, K., Warren, A., Washburn, H., Wilson, E., Zagarra, L., Batton, K. M., Chellini, D., DeWitt, K., Fleming, D. R., Newton-Foster, C., MacDonald, R., Ott, J., Peterson, J., Sallas, M., Teepe, M., Thomas, R., Torrence, K., Hildestad, J., Hartman, T. E., Jett, J. R., McCollough, C. H., Midthun, B. E., Andrist, B. R., Hanson, N. E., Sathre, C. L., Schroeder, L. B., Sheeran, J. R., Walters, L. C., Andrist, C. L., Bungum, A. O., Bornhorst, C. L., Beno, B. M., Krpata, T. S., Lambrecht, A. M., McKey, C. M., Prudoehl, B. K., Richter, H. R., Brisendine, A., Adrales-Bentz, T., Arnold, K., Benjamin, B., Bodd, A., Keller, J., Saunders, T., Spicker, P., Shannon, S., Bailey, L., Comer, H., Espiritu, J., Helwi, S., Mack-Pipkin, B., Tockman, M., Evans, B., Wadhwa, N., Baptiste, N., Eysmans, C., Vera-Gonzalez, N., Hamm, L., Harjani, V., Sear, A., Blackwell, S., Fernandez, A., Williams, E., Coleman, K. A., Afiat, J., Kirchoff, L., Bowman, R., Brothers, C., Cohen, B., Fields, N., Guzman, R., Monje, C., Sterling, W., Thorpe, L., White, K., Williams, B., Nekervis, E., Franco, A., Glick, L., Grigolo, M., Harts, Y., Migo, A., Rockwell, K. P., Stein, A., Weyls, R., Berns, E., Biringer, M. T., Pino, A. D., Dubbs, P., Fehrmann, G. M., Goodwin, A. L., Granger, L., Haglage, J., Hirschy, J., King, M., Kristopher, J. W., Mac, N. M., Mahoney, G., Markarian, A., Ramirez, M., Taylor, M., West, K. M., Sullivan, M. A., Matthews, C. C., Jones, J., Cole, A., Dow, P., Fearon, J., Fodera, B., Ginther, B., McCall, R. L., Williams, S., Young, S., Juul, C., LaFleur, A., Lohmann, K., Pineda, L., Schmidt, A., Wright, S., Greenup, S., McNulty, K., Pawlak, S., Porter, H., Lanning, T., Loria, D., Cook, A., Sky, J. A. H., Boulos, A., Dalal, P., Dickstein, B., DuChateau, A., Engartner, C., Evans, D. M., Evans, J., Evans, K., Gemmel, M., Hallsky, S., Hoffman, P., Hritz, C., Kerchum, L., Kolich, M., Kolich, M., Kolich, M., Kumar, N., Lobaugh, J., Love, C., Love, D., Love, M., Marchese, M., Nelson, D., Petkus, C., Petruzzi, M., Raver, C., Schuler, E., Schuler, P., Schultz, D., Kobistek, R., Jackson, J., Ziegler, J., Fleischer, J., Welch, L. L., Acerra, M., Brittain, B., Conklin, L., Cyphert, C., Delfosse, B., Franceshelli, L., Fuller, J., Garland, D., Gocala, P. J., Grunenwald, M., Kowalik, D., Kurjan, S. L., Lavernick, P., Maderitz, J., Metz, R., Quinn, R., Semansky, M., Smith, S., St.Claire, A., Taybus, P., Wisler, D., Zubena, K., Duda, C., Kay, P., Trapnell, P., Vlachou, M., Bigby, B. B., Gallego, A., Hamm, G., Spivak, J., Pollard, M., Brown, E., Campa, O., Carter, B., Clark, S., Flores, M., Ho, J., Lee, T., Lewis, B., McMahon, J., Momongan, L., Ngo, J., Perryman, A., Rivas, N., Romo, C., Sookpisal, K., Stone, L., Voight, B., Williams, C., Adams, K., Do, P., Engber, K., Henry, L., Khalili, M., Morales, S., O'Carroll, C., Quijano, J., Borgheian, S., Inatomi, R., Lorenzo, A., Lorenzo, D., Nyborg, G., Salazar, V., Woo, M., Beck, P., Beerman, P., Jacobsen, J., Voight, K., Allman, E., Chen, S., Farkas, C., Forter, I., Marcus, P., Matthews, L., Phillips, R., Silva-Gietzen, J., Sturgeon, E., Varner, G., Mullen, B., Stanford, W., Hoffman, E., Sprenger, K., Chapman, A., Crawford, K., Marietta, J., Kmetty, L., Meier, J., Pirotte, P., Rathmell, L., Hudson, M., Sieren, J., Cronin, P., Gross, B., Kelly, A., Patel, S., Pernicano, P., Holloway, L., Chalom, G., Henricks, E., Pool, J., Shepherd, D., Zapolski, D., Goodsitt, M., Hooks, H., Gefter, W., Lynn Werner, D., Smith, C. E., Choi, B. K., Lee, J. K., Holland, C., Matuza, J., Nosker, H. C., Russell, W., Cupp, S., O'Shea, M., Munden, R., Cates, M., Sanchez, E., Aganon-Acheta, M., Black, M., Blalock, D., Brown, C., Cromwell, H., Dunnington, J., Erasmus, J., Gladish, G., Gupta, S., Haynes, M. W., Hensley, T., Iyer, R. B., Madewell, J., Malbari, T., Marom, E. M., Morice, R., Rao, S., Sabloff, B., Scully, N. F., Tekchandani, S., Truong, M., Wicks, D., Geiser, W. R., Montague, J. L., Patel, M., Robinson, T., Donnelly, E. F., Thielke, E., Bell, A. M., Pickens, D. R., Bowman, W. A., Herron, T., Shone, D., Chin, B., Chen, M., Harmon, L., Hinshaw, L., Nelson, C., Biracree, D., Boyles, D., Burrough, A., Davis, A., Drake, E., Frost, E., Long, A., Bowman, E. & Dyer, S., Jan 1 2011, In: RADIOLOGY. 258, 1, p. 243-253 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    932 Scopus citations

  • The regulatory function of SPARC in vascular biology

    Rivera, L. B., Bradshaw, A. D. & Brekken, R. A., Oct 2011, In: Cellular and Molecular Life Sciences. 68, 19, p. 3165-3173 9 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    77 Scopus citations

  • The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity

    Wollam, J., Magomedova, L., Magner, D. B., Shen, Y., Rottiers, V., Motola, D. L., Mangelsdorf, D. J., Cummins, C. L. & Antebi, A., Oct 2011, In: Aging Cell. 10, 5, p. 879-884 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    56 Scopus citations

  • The role of the vitamin D receptor in bile acid homeostasis

    Schmidt, D. R., Kliewer, S. A. & Mangelsdorf, D. J., 2011, Vitamin D. Elsevier Inc., p. 763-767 5 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    2 Scopus citations

  • The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells

    Cao, N., Cheng, D., Zou, S., Ai, H., Gao, J. & Shuai, X., Mar 2011, In: Biomaterials. 32, 8, p. 2222-2232 11 p.

    Research output: Contribution to journal › Article › peer-review

    211 Scopus citations

  • The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

    Adeyo, O., Horn, P. J., Lee, S., Binns, D. D., Chandrahas, A., Chapman, K. D. & Goodman, J. M., Mar 21 2011, In: Journal of Cell Biology. 192, 6, p. 1043-1055 13 p.

    Research output: Contribution to journal › Article › peer-review

    230 Scopus citations

  • Thiazolidinediones on PPARγ: The roles in bone remodeling

    Wei, W. & Wan, Y., 2011, In: PPAR Research. 867180.

    Research output: Contribution to journal › Review article › peer-review

    38 Scopus citations

  • Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

    Younger, S. T. & Corey, D. R., Jul 2011, In: Nucleic acids research. 39, 13, p. 5682-5691 10 p.

    Research output: Contribution to journal › Article › peer-review

    169 Scopus citations

  • Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini

    Younger, S. T. & Corey, D. R., Aug 1 2011, In: Molecular BioSystems. 7, 8, p. 2383-2388 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    25 Scopus citations

  • Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer

    Gelmedin, V., Brodigan, T., Gao, X., Krause, M., Wang, Z. & Hawdon, J. M., Oct 7 2011, In: PloS one. 6, 10, e25996.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    15 Scopus citations

  • Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle

    Zhou, J., Shrikhande, G., Xu, J., Mckay, R. M., Burns, D. K., Johnson, J. E. & Parada, L. F., Aug 1 2011, In: Genes and Development. 25, 15, p. 1595-1600 6 p.

    Research output: Contribution to journal › Article › peer-review

    92 Scopus citations

  • Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells

    Amcheslavsky, A., Ito, N., Jiang, J. & Tony Ip, Y., May 16 2011, In: Journal of Cell Biology. 193, 4, p. 695-710 16 p.

    Research output: Contribution to journal › Article › peer-review

    78 Scopus citations

  • Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells

    Zhou, K., Wang, Y., Huang, X., Luby-Phelps, K., Sumer, B. D. & Gao, J., Jun 27 2011, In: Angewandte Chemie - International Edition. 50, 27, p. 6109-6114 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    466 Scopus citations

  • Ultrasensitive protein detection using lithographically defined Si multi-nanowire field effect transistors

    Tian, R., Regonda, S., Gao, J., Liu, Y. & Hu, W., Jun 7 2011, In: Lab on a Chip. 11, 11, p. 1952-1961 10 p.

    Research output: Contribution to journal › Article › peer-review

    69 Scopus citations

  • Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

    Kucejova, B., Sunny, N. E., Nguyen, A. D., Hallac, R., Fu, X., Pẽa-Llopis, S., Mason, R. P., Deberardinis, R. J., Xie, X. J., Debose-Boyd, R., Kodibagkar, V. D., Burgess, S. C. & Brugarolas, J., May 5 2011, In: Oncogene. 30, 18, p. 2147-2160 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    40 Scopus citations

  • Update on vascular disrupting agents for cancer therapy

    Korpanty, G. & Brekken, R. A., Jul 2011, In: Therapy. 8, 4, p. 403-413 11 p.

    Research output: Contribution to journal › Review article › peer-review

    2 Scopus citations

  • Whole mount in situ hybridization methodology for Schistosoma mansoni

    Cogswell, A. A., Collins, J. J., Newmark, P. A. & Williams, D. L., Jul 2011, In: Molecular and Biochemical Parasitology. 178, 1-2, p. 46-50 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    46 Scopus citations

  • Why human cytochrome P450c21 is a progesterone 21-hydroxylase

    Mizrachi, D., Wang, Z., Sharma, K. K., Gupta, M. K., Xu, K., Dwyer, C. R. & Auchus, R. J., May 17 2011, In: Biochemistry. 50, 19, p. 3968-3974 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • WNK1 is required for mitosis and abscission

    Tu, S. W., Bugde, A., Luby-Phelps, K. & Cobb, M. H., Jan 25 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 4, p. 1385-1390 6 p.

    Research output: Contribution to journal › Article › peer-review

    40 Scopus citations

  • WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling

    An, S. W., Cha, S. K., Yoon, J., Chang, S., Ross, E. M. & Huang, C. L., Dec 6 2011, In: Current Biology. 21, 23, p. 1979-1987 9 p.

    Research output: Contribution to journal › Article › peer-review

    28 Scopus citations

  • Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection

    Ganesan, S. M., Morrisey, J. M., Ke, H., Painter, H. J., Laroiya, K., Phillips, M. A., Rathod, P. K., Mather, M. W. & Vaidya, A. B., May 2011, In: Molecular and Biochemical Parasitology. 177, 1, p. 29-34 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    72 Scopus citations

  • γ-secretase-regulated proteolysis of the notch receptor by mitochondrial intermediate peptidase

    Lee, S. F., Srinivasan, B., Sephton, C. F., Dries, D. R., Wang, B., Yu, C., Wang, Y., Dewey, C. M., Shah, S., Jiang, J. & Yu, G., Aug 5 2011, In: Journal of Biological Chemistry. 286, 31, p. 27447-27453 7 p.

    Research output: Contribution to journal › Article › peer-review

    13 Scopus citations
  • 2010

    5-HT2C Rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

    Xu, Y., Berglund, E. D., Sohn, J. W., Holland, W. L., Chuang, J. C., Fukuda, M., Rossi, J., Williams, K. W., Jones, J. E., Zigman, J. M., Lowell, B. B., Scherer, P. E. & Elmquist, J. K., Dec 2010, In: Nature neuroscience. 13, 12, p. 1457-1459 3 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    75 Scopus citations

  • A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene

    Kohno, T., Otsuka, A., Girard, L., Sato, M., Iwakawa, R., Ogiwara, H., Sanchez-Cespedes, M., Minna, J. D. & Yokota, J., Apr 2010, In: Genes Chromosomes and Cancer. 49, 4, p. 342-352 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    70 Scopus citations

  • Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

    Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In: Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

    Research output: Contribution to journal › Article › peer-review

    48 Scopus citations

  • Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter

    Matsui, M., Sakurai, F., Elbashir, S., Foster, D. J., Manoharan, M. & Corey, D. R., Dec 22 2010, In: Chemistry and Biology. 17, 12, p. 1344-1355 12 p.

    Research output: Contribution to journal › Article › peer-review

    82 Scopus citations

  • Activation of sterol regulatory element binding proteins in the absence of scap in Drosophila melanogaster

    Matthews, K. A., Ozdemir, C. & Rawson, R. B., May 2010, In: Genetics. 185, 1, p. 189-198 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Activation of the T1 neuronal circuit is necessary and sufficient to induce sexually dimorphic mating behavior in Drosophila melanogaster

    Ronderos, D. S. & Smith, D. P., Feb 17 2010, In: Journal of Neuroscience. 30, 7, p. 2595-2599 5 p.

    Research output: Contribution to journal › Article › peer-review

    38 Scopus citations

  • Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission

    Chung, C. H., Barylko, B., Leitz, J., Liu, X. & Kavalali, E. T., Jan 27 2010, In: Journal of Neuroscience. 30, 4, p. 13631376 1 p.

    Research output: Contribution to journal › Article › peer-review

    115 Scopus citations

  • Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling

    Sullivan, J. P., Spinola, M., Dodge, M., Raso, M. G., Behrens, C., Gao, B., Schuster, K., Shao, C., Larsen, J. E., Sullivan, L. A., Honorio, S., Xie, Y., Scaglioni, P. P., DiMaio, J. M., Gazdar, A. F., Shay, J. W., Wistuba, I. I. & Minna, J. D., Dec 1 2010, In: Cancer research. 70, 23, p. 9937-9948 12 p.

    Research output: Contribution to journal › Article › peer-review

    343 Scopus citations

  • ALK Inhibition for Non-Small Cell Lung Cancer: From Discovery to Therapy in Record Time

    Gerber, D. E. & Minna, J. D., Dec 14 2010, In: Cancer Cell. 18, 6, p. 548-551 4 p.

    Research output: Contribution to journal › Review article › peer-review

    195 Scopus citations

  • Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism

    Hu, J., Liu, J. & Corey, D. R., Nov 24 2010, In: Chemistry and Biology. 17, 11, p. 1183-1188 6 p.

    Research output: Contribution to journal › Article › peer-review

    85 Scopus citations

  • Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat

    Gagnon, K. T., Pendergraff, H. M., Deleavey, G. F., Swayze, E. E., Potier, P., Randolph, J., Roesch, E. B., Chattopadhyaya, J., Damha, M. J., Bennett, C. F., Montaillier, C., Lemaitre, M. & Corey, D. R., Nov 30 2010, In: Biochemistry. 49, 47, p. 10166-10178 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    118 Scopus citations

  • Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations

    Sun, C., Southard, C., Witonsky, D. B., Kittler, R. & Di Rienzo, A., Oct 2010, In: PLoS genetics. 6, 10, p. 1-10 10 p., e1001178.

    Research output: Contribution to journal › Article › peer-review

    20 Scopus citations

  • Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a

    Shultz, J. C., Goehe, R. W., Wijesinghe, D. S., Murudkar, C., Hawkins, A. J., Shay, J. W., Minna, J. D. & Chalfant, C. E., Nov 15 2010, In: Cancer research. 70, 22, p. 9185-9196 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    112 Scopus citations

  • An interdomain sector mediating allostery in Hsp70 molecular chaperones

    Smock, R. G., Rivoire, O., Russ, W. P., Swain, J. F., Leibler, S., Ranganathan, R. & Gierasch, L. M., 2010, In: Molecular Systems Biology. 6, 414.

    Research output: Contribution to journal › Article › peer-review

    108 Scopus citations

  • An orthotopic lung tumor model for image-guided microirradiation in rats

    Saha, D., Watkins, L., Yin, Y., Thorpe, P., Story, M. D., Song, K., Raghavan, P., Timmerman, R., Chen, B., Minna, J. D. & Solberg, T. D., Jul 2010, In: Radiation research. 174, 1, p. 62-71 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    30 Scopus citations

  • Antiangiogenic activity of 2-deoxy-D-glucose

    Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoglu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A. & Lampidis, T. J., 2010, In: PloS one. 5, 10, e13699.

    Research output: Contribution to journal › Article › peer-review

    96 Scopus citations

  • Antiangiogenic therapy in lung cancer: Focus on vascular endothelial growth factor pathway

    Korpanty, G., Smyth, E., Sullivan, L. A., Brekken, R. A. & Carney, D. N., Jan 2010, In: Experimental Biology and Medicine. 235, 1, p. 3-9 7 p.

    Research output: Contribution to journal › Short survey › peer-review

    Open Access
    42 Scopus citations

  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines

    Moody, M. A., Liao, H. X., Alam, S. M., Scearce, R. M., Plonk, M. K., Kozink, D. M., Drinker, M. S., Zhang, R., Xia, S. M., Sutherland, L. L., Tomaras, G. D., Giles, I. P., Kappes, J. C., Ochsenbauer-Jambor, C., Edmonds, T. G., Soares, M., Barbero, G., Forthal, D. N., Landucci, G., Chang, C., & 8 othersKing, S. W., Kavlie, A., Denny, T. N., Hwang, K. K., Chen, P. P., Thorpe, P. E., Montefiori, D. C. & Haynes, B. F., Apr 12 2010, In: Journal of Experimental Medicine. 207, 4, p. 763-776 14 p.

    Research output: Contribution to journal › Article › peer-review

    48 Scopus citations