Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells

Kejin Zhou; Yiguang Wang; Xiaonan Huang; Katherine Luby-Phelps; Baran D. Sumer; Jinming Gao

doi:10.1002/anie.201100884

Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells

Kejin Zhou, Yiguang Wang, Xiaonan Huang, Katherine Luby-Phelps, Baran D. Sumer, Jinming Gao

Research output: Contribution to journal › Article › peer-review

450 Scopus citations

Abstract

Switch it up: Tunable, pH-responsive nanoparticles can be selectively activated in different endocytic compartments. At high pHvalues, micelle formation (see picture, left) quenches fluorescence by Förster resonance energy transfer. The micelles disassemble at low pHvalues, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug-delivery applications.

Original language	English (US)
Pages (from-to)	6109-6114
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	27
DOIs	https://doi.org/10.1002/anie.201100884
State	Published - Jun 27 2011

Keywords

cell cycle
fluorescent probes
micelles
nanostructures
pH activation

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201100884

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abstract = "Switch it up: Tunable, pH-responsive nanoparticles can be selectively activated in different endocytic compartments. At high pHvalues, micelle formation (see picture, left) quenches fluorescence by F{\"o}rster resonance energy transfer. The micelles disassemble at low pHvalues, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug-delivery applications.",

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AU - Huang, Xiaonan

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AU - Sumer, Baran D.

AU - Gao, Jinming

PY - 2011/6/27

Y1 - 2011/6/27

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KW - fluorescent probes

KW - micelles

KW - nanostructures

KW - pH activation

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Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells

Abstract

Keywords

ASJC Scopus subject areas

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