Pharmacology - Wilkie Lab

Research output

Research output per year 1984 1991 1998 1999 2000 2001 2021 2021

• 59 Article
• 6 Review article
• 2 Comment/debate
• 1 Editorial

Research output per year

Research output per year

Search results

• 2021

  AXL is a key factor for cell plasticity and promotes metastasis in Pancreatic cancer

  Du, W., Phinney, N. Z., Huang, H., Wang, Z., Westcott, J., Toombs, J. E., Zhang, Y., Beg, M. S., Wilkie, T. M., Lorens, J. B. & Brekken, R. A., Aug 1 2021, In: Molecular Cancer Research. 19, 8, p. 1412-1421 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Plasticity 100%
  • Pancreatic Neoplasms 70%
  • Adenocarcinoma 58%
  • Neoplasm Metastasis 46%
  • c-Mer Tyrosine Kinase 19%
  14 Scopus citations

• Gα15 in early onset of pancreatic ductal adenocarcinoma

  Innamorati, G., Wilkie, T. M., Malpeli, G., Paiella, S., Grasso, S., Rusev, B., Leone, B. E., Valenti, M. T., Carbonare, L. D., Cheri, S., Giacomazzi, A., Zanotto, M., Guardini, V., Deiana, M., Zipeto, D., Serena, M., Parenti, M., Guzzi, F., Lawlor, R. T., Malerba, G., & 5 othersMori, A., Malleo, G., Giacomello, L., Salvia, R. & Bassi, C., Dec 2021, In: Scientific reports. 11, 1, 14922.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenocarcinoma 100%
  • Ectopic Gene Expression 93%
  • Demethylation 50%
  • Clustered Regularly Interspaced Short Palindromic Repeats 48%
  • GTP-Binding Proteins 42%
  5 Scopus citations

• The Path of Science in Future Tibetan Buddhist Education

  Woodward, D., Ricks, E., Bjorkman, P. J., Tsoulfas, P., Johnson, J. E., Westmoreland, G. & Wilkie, T. M., 2021, In: Frontiers in Communication. 6, 731604.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Teaching 100%
  • Education 96%
  • Tibet 38%
  • religious community 35%
  • education 34%
  1 Scopus citations
• 2020

  Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

  Layeghi-Ghalehsoukhteh, S., Pal Choudhuri, S., Ocal, O., Zolghadri, Y., Pashkov, V., Niederstrasser, H., Posner, B. A., Kantheti, H. S., Azevedo-Pouly, A. C., Huang, H., Girard, L., MacDonald, R. J., Brekken, R. A. & Wilkie, T. M., Dec 2020, In: Scientific reports. 10, 1, 20662.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenocarcinoma 100%
  • Cell Culture Techniques 21%
  • Cell Dedifferentiation 21%
  • Genetic Suppression 19%
  • Ceruletide 19%
  3 Scopus citations

• Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis

  van den Bos, E., Ambrosy, B., Horsthemke, M., Walbaum, S., Bachg, A. C., Wettschureck, N., Innamorati, G., Wilkie, T. M. & Hanley, P. J., May 28 2020, In: Journal of Biological Chemistry. 295, 22, p. 7726-7742 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Complement C5a 100%
  • Protein Subunits 74%
  • Chemotaxis 70%
  • Spreading 69%
  • GTP-Binding Proteins 65%
  8 Scopus citations
• 2018

  Malnutrition in Pancreatic Ductal Adenocarcinoma (PDA): Dietary Pancreatic Enzymes Improve Short-Term Health but Stimulate Tumor Growth

  Zolghadri, Y., Pal Choudhuri, S., Ocal, O., Layeghi-Ghalehsoukhteh, S., Berhe, F., Hale, M. A. & Wilkie, T. M., Mar 2018, In: American Journal of Pathology. 188, 3, p. 616-626 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Malnutrition 100%
  • Adenocarcinoma 83%
  • Enzymes 58%
  • Growth 53%
  • Health 51%
  5 Scopus citations

• The curious case of Gαs gain-of-function in neoplasia

  Innamorati, G., Wilkie, T. M., Kantheti, H. S., Valenti, M. T., Dalle Carbonare, L., Giacomello, L., Parenti, M., Melisi, D. & Bassi, C., Mar 15 2018, In: BMC Cancer. 18, 1, 293.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Polyostotic Fibrous Dysplasia 90%
  • Gain of Function Mutation 78%
  • Neoplasms 76%
  • Phenotype 71%
  17 Scopus citations
• 2016

  The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

  Wieczorek, M., Tcherkezian, J., Bernier, C., Prota, A. E., Chaaban, S., Rolland, Y., Godbout, C., Hancock, M. A., Arezzo, J. C., Ocal, O., Rocha, C., Olieric, N., Hall, A., Ding, H., Bramoullé, A., Annis, M. G., Zogopoulos, G., Harran, P. G., Wilkie, T. M., Brekken, R. A., & 5 othersSiegel, P. M., Steinmetz, M. O., Shore, G. C., Brouhard, G. J. & Roulston, A., Nov 16 2016, In: Science translational medicine. 8, 365

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DZ-2384 100%
  • Microtubules 39%
  • Vinca 19%
  • Tubulin 18%
  • Vinca Alkaloids 8%
  35 Scopus citations
• 2015

  A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

  Ocal, O., Pashkov, V., Kollipara, R. K., Zolghadri, Y., Cruz, V. H., Hale, M. A., Heath, B. R., Artyukhin, A. B., Christie, A. L., Tsoulfas, P., Lorens, J. B., Swift, G. H., Brekken, R. A. & Wilkie, T. M., Oct 1 2015, In: DMM Disease Models and Mechanisms. 8, 10, p. 1201-1211 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Marker 100%
  • RNA Sequencing 94%
  • Adenocarcinoma 89%
  • Gemcitabine 85%
  • Warfarin 76%
  14 Scopus citations
• 2013

  The G protein Gα11 is essential for hypertrophic signalling in diabetic myocardium

  Reuter, H., Seuthe, K., Korkmaz, Y., Grönke, S., Hoyer, D. P., Rottlaender, D., Zobel, C., Addicks, K., Hoyer, J., Grimminger, P., Brabender, J., Wilkie, T. M. & Erdmann, E., Aug 20 2013, In: International Journal of Cardiology. 167, 4, p. 1476-1485 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gq-G11 GTP-Binding Protein alpha Subunits 100%
  • Knockout Mice 58%
  • Myocardium 53%
  • Calcineurin 53%
  • Cardiomegaly 46%
  6 Scopus citations
• 2011

  Regulator of G protein signaling (Rgs16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner

  Pashkov, V., Huang, J., Parameswara, V. K., Kedzierski, W., Kurrasch, D. M., Tall, G. G., Esser, V., Gerard, R. D., Uyeda, K., Towle, H. C. & Wilkie, T. M., Apr 29 2011, In: Journal of Biological Chemistry. 286, 17, p. 15116-15125 10 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Response Elements 72%
  • Carbohydrates 58%
  • Fatty Acids 57%
  • Carrier Proteins 56%
  43 Scopus citations
• 2010

  Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes

  Villasenor, A., Wang, Z. V., Rivera, L. B., Ocal, O., Asterholm, I. W., Scherer, P. E., Brekken, R. A., Cleaver, O. & Wilkie, T. M., Sep 2010, In: DMM Disease Models and Mechanisms. 3, 9-10, p. 567-580 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Incretin Mimetic 100%
  • Exendin-4 79%
  • Glucagon-Like Peptide 1 70%
  • Insulin Derivative 45%
  • Islets of Langerhans 44%
  33 Scopus citations
• 2006

  Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes

  Huang, J., Pashkov, V., Kurrasch, D. M., Yu, K., Gold, S. J. & Wilkie, T. M., Nov 23 2006, In: Comparative Hepatology. 5, 8.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Hepatocytes 56%
  • Fasting 53%
  • Liver 34%
  • RGS Proteins 22%
  26 Scopus citations
• 2004

  Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling

  Tu, Y. & Wilkie, T. M., 2004, In: Methods in Enzymology. 389, p. 89-1005 917 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Allosteric Regulation 99%
  • GTPase-Activating Proteins 90%
  • Phosphatidic Acids 88%
  • Phosphatidic Acid 66%
  17 Scopus citations

• Differentially Regulated Expression of Endogenous RGS4 and RGS7

  Krumins, A. M., Barker, S. A., Huang, C., Sunahara, R. K., Yu, K., Wilkie, T. M., Gold, S. J. & Mumby, S. M., Jan 23 2004, In: Journal of Biological Chemistry. 279, 4, p. 2593-2599 7 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Proteolysis 47%
  • Transfection 43%
  • Protein 34%
  • RGS4 protein 32%
  60 Scopus citations

• Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues

  Kurrasch, D. M., Huang, J., Wilkie, T. M. & Repa, J. J., 2004, In: Methods in Enzymology. 389, p. 3-15 13 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Chain Reaction 65%
  • RGS Proteins 61%
  • Real-Time Polymerase Chain Reaction 52%
  • Messenger RNA 38%
  75 Scopus citations
• 2003

  Gα_q and Gα₁₁ proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme

  Ivey, K., Tyson, B., Ukidwe, P., McFadden, D. G., Levi, G., Olson, E. N., Srivastava, D. & Wilkie, T. M., Mar 15 2003, In: Developmental Biology. 255, 2, p. 230-237 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gq-G11 GTP-Binding Protein alpha Subunits 100%
  • Branchial Region 88%
  • Neural Crest 74%
  • Endothelin-1 69%
  • Mesoderm 69%
  51 Scopus citations

• Methacholine-induced airway hyperresponsiveness is dependent on Gα_q signaling

  Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1, p. L114-L120

  Research output: Contribution to journal › Article › peer-review

  • Methacholine Chloride 100%
  • Cholinergic Receptors 92%
  • Allergens 78%
  • Smooth Muscle 73%
  • Gq-G11 GTP-Binding Protein alpha Subunits 65%
  18 Scopus citations
• 2002

  Evolution of the regulators of G-protein signaling multigene family in mouse and human

  Sierra, D. A., Gilbert, D. J., Householder, D., Grishin, N. V., Yu, K., Ukidwe, P., Barker, S. A., He, W., Wensel, T. G., Otero, G., Brown, G., Copeland, N. G., Jenkins, N. A. & Wilkie, T. M., Feb 2002, In: Genomics. 79, 2, p. 177-185 9 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Multigene Family 72%
  • RGS Proteins 41%
  • human RGS21 protein 34%
  • human RGS18 protein 33%
  77 Scopus citations
• 2001

  Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gα_q/Gα₁₁ in cardiomyocytes

  Wettschureck, N., Rütten, H., Zywietz, A., Gehring, D., Wilkie, T. M., Chen, J., Chien, K. R. & Offermanns, S., 2001, In: Nature medicine. 7, 11, p. 1236-1240 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cardiac Myocytes 100%
  • Hypertrophy 97%
  • G12 89%
  • Endothelin-1 80%
  • Pressure 69%
  325 Scopus citations

• Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase Cβ₁

  Dowal, L., Elliott, J., Popov, S., Wilkie, T. M. & Scarlata, S., Jan 16 2001, In: Biochemistry. 40, 2, p. 414-421 8 p.

  Research output: Contribution to journal › Article › peer-review

  • phospholipase C1 100%
  • RGS Proteins 70%
  • Protein Subunits 52%
  • GTP-Binding Proteins 45%
  • Energy 21%
  49 Scopus citations

• Polarized Expression of G Protein-coupled Receptors and an All-or-None Discharge of Ca²⁺ Pools at Initiation Sites of [Ca²⁺] _i Waves in Polarized Exocrine Cells

  Shin, D. M., Luo, X., Wilkie, T. M., Miller, L. J., Peck, A. B., Humphreys-Beher, M. G. & Muallem, S., Nov 23 2001, In: Journal of Biological Chemistry. 276, 47, p. 44146-44156 11 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors 100%
  • Wave 92%
  • Acinar Cells 58%
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases 37%
  • Inositol 1,4,5-Trisphosphate 31%
  56 Scopus citations

• RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes

  Yowe, D., Weich, N., Prabhudas, M., Poisson, L., Errada, P., Kapeller, R., Yu, K., Faron, L., Shen, M., Cleary, J., Wilkie, T. M., Gutierrez-Ramos, C. & Hodge, M. R., Oct 1 2001, In: Biochemical Journal. 359, 1, p. 109-118 10 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Megakaryocytes 80%
  • RGS Proteins 51%
  • Yeasts 40%
  • G-Protein-Coupled Receptors 33%
  55 Scopus citations

• RGS domain: Production and uses of recombinant protein

  Yowe, D., Yu, K., Wilkie, T. M. & Popov, S., 2001, In: Methods in Enzymology. 344, p. 647-657 11 p.

  Research output: Contribution to journal › Article › peer-review
  2 Scopus citations

• RGS proteins provide biochemical control of agonist-evoked [Ca²⁺]_i oscillations

  Luo, X., Popov, S., Bera, A. K., Wilkie, T. M. & Muallem, S., Mar 1 2001, In: Molecular cell. 7, 3, p. 651-660 10 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • G-Protein-Coupled Receptors 21%
  • Biophysical Phenomena 18%
  • Inositol 1,4,5-Trisphosphate Receptors 14%
  • Biochemical Phenomena 14%
  75 Scopus citations

• Treasures throughout the life-cycle of G-protein-coupled receptors

  Wilkie, T. M., Aug 1 2001, In: Trends in Pharmacological Sciences. 22, 8, p. 396-397 2 p.

  Research output: Contribution to journal › Article › peer-review
  7 Scopus citations
• 2000

  Ca²⁺/calmodulin reverses phosphatidylinositol 3,4,5-trisphosphate- dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

  Popov, S. G., Murali Krishna, U., Falck, J. R. & Wilkie, T. M., Jun 23 2000, In: Journal of Biological Chemistry. 275, 25, p. 18962-18968 7 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • phosphatidylinositol 3,4,5-triphosphate 97%
  • GTPase-Activating Proteins 90%
  • Phosphatidylinositol 80%
  • Calmodulin 73%
  111 Scopus citations

• Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Gα15 knockout mice

  Davignon, I., Catalina, M. D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M. & Wilkie, T. M., Feb 2000, In: Molecular and cellular biology. 20, 3, p. 797-804 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoiesis 100%
  • Knockout Mice 84%
  • Thioglycolates 51%
  • Macrophages 38%
  • Gq-G11 GTP-Binding Protein alpha Subunits 28%
  43 Scopus citations
• 1999

  Alternate coupling of receptors to G(s) and G(i) in pancreatic and submandibular gland cells

  Xiang, L., Zeng, W., Xu, X., Popov, S., Davignon, I., Wilkie, T. M., Mumby, S. M. & Muallem, S., Jun 18 1999, In: Journal of Biological Chemistry. 274, 25, p. 17684-17690 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Submandibular Gland 100%
  • Cyclic AMP-Dependent Protein Kinases 87%
  • Adrenergic Receptors 53%
  • Heterotrimeric GTP-Binding Proteins 37%
  • Peptide Receptors 35%
  59 Scopus citations

• Differential involvement of Gα₁₂ and Gα₁₃ in receptor-mediated stress fiber formation

  Gohla, A., Offermanns, S., Wilkie, T. M. & Schultz, G., Jun 18 1999, In: Journal of Biological Chemistry. 274, 25, p. 17901-17907 7 p.

  Research output: Contribution to journal › Article › peer-review

  • G12 100%
  • Stress Fibers 75%
  • Fiber 38%
  • Lysophosphatidic Acid 23%
  • Receptor, Serotonin, 5-HT2C 21%
  196 Scopus citations

• G proteins, chemosensory perception, and the C. elegans genome project: An attractive story

  Wilkie, T. M., 1999, In: BioEssays. 21, 9, p. 713-717 5 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Proteins 100%
  • Caenorhabditis elegans 82%
  • Genome 68%
  • Heterotrimeric GTP-Binding Proteins 67%
  • Protein 41%
  4 Scopus citations

• Overexpression of G(11α) and isoforms of phospholipase C in islet β- cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion

  Gasa, R., Trinh, K. Y., Yu, K., Wilkie, T. M. & Newgard, C. B., 1999, In: Diabetes. 48, 5, p. 1035-1044 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Inositol Phosphates 100%
  • Type C Phospholipases 88%
  • Islets of Langerhans 79%
  • Insulin Secretion 78%
  • Protein Isoforms 63%
  24 Scopus citations

• RGS proteins determine signaling specificity of G(q)-coupled receptors

  Xu, X., Zeng, W., Popov, S., Berman, D. M., Davignon, I., Yu, K., Yowe, D., Offermanns, S., Muallem, S. & Wilkie, T. M., Feb 5 1999, In: Journal of Biological Chemistry. 274, 6, p. 3549-3556 8 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • Cholecystokinin 76%
  • Carbachol 72%
  • Protein 26%
  • GTPase-Activating Proteins 21%
  233 Scopus citations
• 1998

  Embryonic cardiomyocyte hypoplasia and craniofacial defects in Gα(q)/Gα₁₁-mutant mice

  Offermanns, S., Zhao, L. P., Gohla, A., Sarosi, I., Simon, M. I. & Wilkie, T. M., Aug 3 1998, In: EMBO Journal. 17, 15, p. 4304-4312 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cardiac Myocytes 100%
  • Alleles 52%
  • Heterotrimeric GTP-Binding Proteins 47%
  • Mutation 45%
  • Protein 44%
  208 Scopus citations

• Gonadotropin and gonadal steroid release in response to a gonadotropin- releasing hormone agonist in G(q)α and G₁₁α knockout mice

  Stanislaus, D., Janovick, J. A., Ji, T., Wilkie, T. M., Offermanns, S. & Conn, P. M., 1998, In: Endocrinology. 139, 6, p. 2710-2717 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Buserelin 100%
  • Gonadotropins 82%
  • Gonadotropin-Releasing Hormone 78%
  • Knockout Mice 72%
  • Steroids 58%
  21 Scopus citations

• Promiscuous coupling of receptors to Gq class α subunits and effector proteins in pancreatic and submandibular gland cells

  Xu, X., Croy, J. T., Zeng, W., Zhao, L., Davignon, I., Popov, S., Yu, K., Jiang, H., Offermanns, S., Muallem, S. & Wilkie, T. M., Oct 16 1998, In: Journal of Biological Chemistry. 273, 42, p. 27275-27279 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Bombesin 100%
  • Adrenergic 87%
  • Parasympathomimetic Agent 82%
  • Submandibular Gland 79%
  • Protein Subunits 75%
  41 Scopus citations

• The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

  Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In: Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

  Research output: Contribution to journal › Article › peer-review

  • GTPase-Activating Proteins 100%
  • Guanosine Triphosphate 78%
  • GTP-Binding Proteins 73%
  • Hydrolysis 68%
  • RGS Proteins 57%
  220 Scopus citations

• The n terminal domain of RGS4 confers regulatory specificity in g protein-receptor signaling

  Wilkie, T. M., Popov, S., Zeug, W., Xu, X. & Muallem, S., 1998, In: FASEB Journal. 12, 8, p. A1314

  Research output: Contribution to journal › Article › peer-review

  • Knockout Mice 100%
  • Agonist 78%
  • GTPase-Activating Proteins 73%
  • Protein 67%
  • Acinar Cells 64%
• 1997

  The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro

  Popov, S., Yu, K., Kozasa, T. & Wilkie, T. M., Jul 8 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 14, p. 7216-7220 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GTPase-Activating Proteins 100%
  • Protein Domains 74%
  • GTP-Binding Proteins 73%
  • RGS Proteins 45%
  • In Vitro Techniques 32%
  150 Scopus citations
• 1996

  GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein α subunits

  Berman, D. M., Wilkie, T. M. & Gilman, A. G., Aug 9 1996, In: Cell. 86, 3, p. 445-452 8 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • GTPase-Activating Proteins 87%
  • Protein Subunits 73%
  • GTP-Binding Proteins 64%
  • GTP-Binding Protein Regulators 64%
  664 Scopus citations

• Gene structure of murine Gna11 and Gna15: Tandemly duplicated Gq class G protein α subunit genes

  Davignon, I., Barnard, M., Gavrilova, O., Sweet, K. & Wilkie, T. M., Feb 1 1996, In: Genomics. 31, 3, p. 359-366 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gq-G11 GTP-Binding Protein alpha Subunits 100%
  • Protein Subunits 73%
  • Genes 25%
  • Chromosomes, Human, Pair 10 7%
  • Intergenic DNA 7%
  27 Scopus citations

• G protein alpha subunit multigene family in the Japanese puffer fish Fugu rubripes: PCR from a compact vertebrate genome

  Sarwal, M. M., Sontag, J. M., Hoang, L., Brenner, S. & Wilkie, T. M., 1996, In: Genome Research. 6, 12, p. 1207-1215 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Takifugu 100%
  • Tetraodontiformes 96%
  • GTP-Binding Protein alpha Subunits 91%
  • Multigene Family 68%
  • Vertebrates 56%
  13 Scopus citations
• 1994

  Design of degenerate oligonucleotide primers for cloning of G-protein a subunits

  Wilkie, T. M., Aragay, A. M., Watson, A. J. & Simon, M. I., Jan 1 1994, In: Methods in Enzymology. 237, C, p. 327-344 18 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Primer 100%
  • DNA Primers 94%
  • Protein Subunits 81%
  • GTP-Binding Proteins 71%
  • Chain Reaction 70%
  9 Scopus citations

• Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen

  Wilkie, T. M., Schmidt, R. A., Baetscher, M. & Messing, A., Oct 1994, In: Oncogene. 9, 10, p. 2889-2895 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscle Neoplasms 100%
  • Polyomavirus Transforming Antigens 90%
  • Bone Neoplasms 80%
  • Transgenic Mice 58%
  • Smooth Muscle 57%
  20 Scopus citations
• 1993

  Identification, chromosomal location, and genome organization of mammalian g-protein-coupled receptors

  Wilkie, T. M., Chen, Y., Gilbert, D. J., Moore, K. J., Yu, L., Simon, M. I., Copeland, N. G. & Jenkins, N. A., Nov 1993, In: Genomics. 18, 2, p. 175-184 10 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors 100%
  • Genome 67%
  • Proteins 36%
  • Clone Cells 36%
  • Chromosomes, Human, Pair 1 22%
  60 Scopus citations

• Mutational analysis of G protein α subunit G_oα expressed in Escherichia coli

  Slepak, V. Z., Wilkie, T. M. & Simon, M. I., Jan 15 1993, In: Journal of Biological Chemistry. 268, 2, p. 1414-1423 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gi-Go GTP-Binding Protein alpha Subunits 100%
  • GTP-Binding Proteins 65%
  • ADP-Ribosylation 59%
  • Mutation 55%
  • Guanine Nucleotides 53%
  38 Scopus citations
• 1992

  Evolution of the mammalian G protein α subunit multigene family

  Wilkie, T. M., Gilbert, D. J., Olsen, A. S., Chen, X. N., Amatruda, T. T., Korenberg, J. R., Trask, B. J., De Jong, P., Reed, R. R., Simon, M. I., Jenkins, N. A. & Copeland, N. G., May 1992, In: Nature genetics. 1, 2, p. 85-91 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Subunits 100%
  • Multigene Family 94%
  • GTP-Binding Proteins 87%
  • Guanine Nucleotides 36%
  • Genes 35%
  224 Scopus citations
• 1991

  Chararacterization of G-protein α subunits in the G_q class: Expression in murine tissues and in stromal and hematopoietic cell lines

  Wilkie, T. M., Scherle, P. A., Strathmann, M. P., Slepak, V. Z. & Simon, M. I., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 22, p. 10049-10053 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Subunits 100%
  • Stromal Cells 88%
  • GTP-Binding Proteins 87%
  • Cell Line 51%
  • Pertussis Toxin 49%
  275 Scopus citations

• Cloning multigene families with degenerate PCR primers

  Wilkie, T. M. & Simon, M. I., Feb 1991, In: Methods. 2, 1, p. 32-41 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Multigene Family 100%
  • Complementary DNA 96%
  • Amino Acid Sequence 85%
  • Organism Cloning 84%
  • Polymerase Chain Reaction 54%
  32 Scopus citations

• Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice

  Wilkie, T. M., Braun, R. E., Ehrman, W. J., Palmiter, R. D. & Hammer, R. E., 1991, In: Genes and Development. 5, 1, p. 38-48 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Transgenes 100%
  • Germ Cells 98%
  • Genetic Recombination 95%
  • Fertility 92%
  • Thymidine Kinase 40%
  27 Scopus citations