Research output per year
Research output per year
- 1 - 50 out of 254 results
Search results
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2019
2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state
Zhang, Z., Zhang, T., Ge, Y., Tang, M., Ma, W., Zhang, Q., Gong, S., Wright, W. E., Shay, J., Liu, H. & Zhao, Y., Apr 19 2019, In: Journal of Biological Chemistry. 294, 16, p. 6645-6656 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence
Laranger, R., Karimpour-Fard, A., Costa, C., Mathes, D., Wright, W. E. & Chong, T., Feb 1 2019, In: Plastic and reconstructive surgery. 143, 2, p. 490-494 5 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs)
Sayed, M. E., Cheng, A., Yadav, G. P., Ludlow, A. T., Shay, J. W., Wright, W. E. & Jiang, Q. X., Jul 26 2019, In: Journal of Biological Chemistry. 294, 30, p. 11579-11596 18 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52
Min, J., Wright, W. E. & Shay, J. W., Jul 2019, In: Genes and Development. 33, 13-14, p. 814-827 14 p.Research output: Contribution to journal › Article › peer-review
Open Access110 Scopus citations -
Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy
Mueller, A. L., O'Neill, A., Jones, T. I., Llach, A., Rojas, L. A., Sakellariou, P., Stadler, G., Wright, W. E., Eyerman, D., Jones, P. L. & Bloch, R. J., Oct 2019, In: Experimental Neurology. 320, 113011.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells
Sayed, M. E., Yuan, L., Robin, J. D., Tedone, E., Batten, K., Dahlson, N., Wright, W. E., Shay, J. W. & Ludlow, A. T., Apr 18 2019, In: Oncogene. 38, 16, p. 2937-2952 16 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians
Tedone, E., Huang, E., O’Hara, R., Batten, K., Ludlow, A. T., Lai, T. P., Arosio, B., Mari, D., Wright, W. E. & Shay, J. W., Feb 2019, In: Aging Cell. 18, 1, e12859.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Telomeres and telomerase: three decades of progress
Shay, J. W. & Wright, W. E., May 1 2019, In: Nature Reviews Genetics. 20, 5, p. 299-309 11 p.Research output: Contribution to journal › Article › peer-review
497 Scopus citations -
2018
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
Ludlow, A. T., Wong, M. S., Robin, J. D., Batten, K., Yuan, L., Lai, T. P., Dahlson, N., Zhang, L., Mender, I., Tedone, E., Sayed, M. E., Wright, W. E. & Shay, J. W., Dec 1 2018, In: Nature communications. 9, 1, 3112.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells
Laranger, R., Peters-Hall, J. R., Coquelin, M., Alabi, B. R., Chen, C. T., Wright, W. E. & Shay, J. W., Apr 2018, In: Tissue Engineering - Part A. 24, 7-8, p. 559-568 10 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance
Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 2018, In: Neoplasia (United States). 20, 8, p. 826-837 12 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Truncated adenomatous polyposis coli mutation induces Asef-activated Golgi fragmentation
Kim, S. B., Zhang, L., Yoon, J., Lee, J., Min, J., Li, W., Grishin, N. V., Moon, Y. A., Wright, W. E. & Shay, J. W., Sep 1 2018, In: Molecular and cellular biology. 38, 17, e00135-18.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2017
Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands
Min, J., Wright, W. E. & Shay, J. W., Mar 17 2017, In: Nucleic acids research. 45, 5, p. 2615-2628 14 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Alternative lengthening of telomeres mediated by mitotic DNA synthesis engages breakinduced replication processes
Min, J., Wright, W. E. & Shay, J. W., Oct 1 2017, In: Molecular and cellular biology. 37, 20, e00226-17.Research output: Contribution to journal › Article › peer-review
Open Access138 Scopus citations -
A method for measuring the distribution of the shortest telomeres in cells and tissues
Lai, T. P., Zhang, N., Noh, J., Mender, I., Tedone, E., Huang, E., Wright, W. E., Danuser, G. & Shay, J. W., Dec 1 2017, In: Nature communications. 8, 1, 1356.Research output: Contribution to journal › Article › peer-review
Open Access102 Scopus citations -
The Maintenance of Telomere Length in CD28+ T Cells during T Lymphocyte Stimulation
Huang, E., Tedone, E., O'Hara, R., Cornelius, C., Lai, T. P., Ludlow, A., Wright, W. E. & Shay, J. W., Dec 1 2017, In: Scientific reports. 7, 1, 6785.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2016
Comparison of DNA quantification methods for next generation sequencing
Robin, J. D., Ludlow, A. T., La Ranger, R., Wright, W. E. & Shay, J. W., Apr 6 2016, In: Scientific reports. 6, 24067.Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
Generation of digoxigeninincorporated probes to enhance DNA detection sensitivity
Lai, T. P., Wright, W. E. & Shay, J. W., Jun 2016, In: BioTechniques. 60, 6, p. 306-309 4 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency
Holohan, B., Kim, W., Lai, T. P., Hoshiyama, H., Zhang, N., Alazami, A. M., Wright, W. E., Meyn, M. S., Alkuraya, F. S. & Shay, J. W., Oct 17 2016, In: BMC Genomics. 17, 749.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Neuromuscular electrical stimulation promotes development in mice of mature human muscle from immortalized human myoblasts
Sakellariou, P., O'Neill, A., Mueller, A. L., Stadler, G., Wright, W. E., Roche, J. A. & Bloch, R. J., Feb 27 2016, In: Skeletal Muscle. 6, 1, 4.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses
Kim, S. B., Bozeman, R. G., Kaisani, A., Kim, W., Zhang, L., Richardson, J. A., Wright, W. E. & Shay, J. W., Jun 30 2016, In: Oncogene. 35, 26, p. 3365-3375 11 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
Kim, W., Ludlow, A. T., Min, J., Robin, J. D., Stadler, G., Mender, I., Lai, T. P., Zhang, N., Wright, W. E. & Shay, J. W., Dec 15 2016, In: PLoS biology. 14, 12, e2000016.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer
Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y. A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., De Brabander, J. K. & Shay, J. W., Oct 19 2016, In: Science translational medicine. 8, 361, 361ra140.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
The metastatic potential and chemoresistance of human pancreatic cancer stem cells
Bhagwandin, V. J., Bishop, J. M., Wright, W. E. & Shay, J. W., Feb 1 2016, In: PloS one. 11, 2, e0148807.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
2015
Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening
Holohan, B., De Meyer, T., Batten, K., Mangino, M., Hunt, S. C., Bekaert, S., De Buyzere, M. L., Rietzschel, E. R., Spector, T. D., Wright, W. E. & Shay, J. W., 2015, In: Aging Cell. 14, 4, p. 669-677 9 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells
Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In: Molecular and cellular biology. 35, 14, p. 2425-2435 11 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis
Zhang, L., Kim, S. B., Jia, G., Buhemeida, A., Dallol, A., Wright, W. E., Fornace, A. J., Al-Qahtani, M. & Shay, J. W., Jan 15 2015, In: BMC Genomics. 16, 1, S8.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2′-deoxyguanosine
Mender, I., Gryaznov, S., Dikmen, Z. G., Wright, W. E. & Shay, J. W., 2015, In: Cancer discovery. 5, 1, p. 82-95 14 p.Research output: Contribution to journal › Article › peer-review
Open Access102 Scopus citations -
Isolation and immortalization of patient-derived cell lines from muscle biopsy for disease modeling
Robin, J. D., Wright, W. E., Zou, Y., Cossette, S. C., Lawlor, M. W. & Gussoni, E., Jan 18 2015, In: Journal of Visualized Experiments. 95, e52307.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Perifosine as a potential novel anti-telomerase therapy
Holohan, B., Hagiopian, M. M., Lai, T. P., Huang, E., Friedman, D. R., Wright, W. E. & Shay, J. W., 2015, In: Oncotarget. 6, 26, p. 21816-21826 11 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
Pandita, R. K., Chow, T. T., Udayakumar, D., Bain, A. L., Cubeddu, L., Hunt, C. R., Shi, W., Horikoshi, N., Zhao, Y., Wright, W. E., Khanna, K. K., Shay, J. W. & Pandita, T. K., Mar 1 2015, In: Cancer research. 75, 5, p. 858-869 12 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy
Robin, J. D., Ludlow, A. T., Batten, K., Gaillard, M. C., Stadler, G., Magdinier, F., Wright, W. E. & Shay, J. W., Dec 2015, In: Genome Research. 25, 12, p. 1781-1790 10 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
2014
Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture
Kaisani, A., Delgado, O., Fasciani, G., Kim, S. B., Wright, W. E., Minna, J. D. & Shay, J. W., Mar 2014, In: Differentiation. 87, 3-4, p. 119-126 8 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
CDDO-me protects normal lung and breast epithelial cells but not cancer cells from radiation
El-Ashmawy, M., Delgado, O., Cardentey, A., Wright, W. E. & Shay, J. W., Dec 23 2014, In: PloS one. 9, 12, e115600.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer
Singel, S. M., Cornelius, C., Zaganjor, E., Batten, K., Sarode, V. R., Buckley, D. L., Peng, Y., John, G. B., Li, H. C., Sadeghi, N., Wright, W. E., Lum, L., Corson, T. W. & Shay, J. W., Mar 2014, In: Neoplasia (United States). 16, 3, p. 247-256.e2 e2.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution
Ludlow, A. T., Robin, J. D., Sayed, M., Litterst, C. M., Shelton, D. N., Shay, J. W. & Wright, W. E., Jul 29 2014, In: Nucleic acids research. 42, 13, p. e104Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer
Delgado, O., Batten, K. G., Richardson, J. A., Xie, X. J., Gazdar, A. F., Kaisani, A. A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W. E., Story, M. D., Wistuba, I. I., Minna, J. D. & Shay, J. W., 2014, In: Clinical Cancer Research. 20, 6, p. 1610-1622 13 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways
Singel, S. M., Batten, K., Cornelius, C., Jia, G., Fasciani, G., Barron, S. L., Wright, W. E. & Shay, J. W., May 19 2014, In: Breast Cancer Research. 16, 2, R28.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Regulation of human telomerase splicing by RNA:RNA pairing
Wong, M. S., Shay, J. W. & Wright, W. E., Feb 28 2014, In: Nature communications. 5, 3306.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Telomere position effect: Regulation of gene expression with progressive telomere shortening over long distances
Robin, J. D., Ludlow, A. T., Batten, K., Magdinier, F., Stadler, G., Wagner, K. R., Shay, J. W. & Wright, W. E., Nov 15 2014, In: Genes and Development. 28, 22, p. 2464-2476 13 p.Research output: Contribution to journal › Article › peer-review
217 Scopus citations -
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch
Lue, N. F., Chan, J., Wright, W. E. & Hurwitz, J., 2014, In: Nature communications. 5, 5762.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
2013
Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation
Ly, P., Kim, S. B., Kaisani, A. A., Marian, G., Wright, W. E. & Shay, J. W., Jun 27 2013, In: Oncogene. 32, 26, p. 3139-3146 8 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer
Singel, S. M., Cornelius, C., Batten, K., Fasciani, G., Wright, W. E., Lum, L. & Shay, J. W., Apr 15 2013, In: Clinical Cancer Research. 19, 8, p. 2061-2070 10 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer
Zhang, L., Komurov, K., Wright, W. E. & Shay, J. W., Feb 1 2013, In: International Journal of Cancer. 132, 3, p. 732-737 6 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Immortalized myogenic cells from congenital muscular dystrophy type1A patients recapitulate aberrant caspase activation in pathogenesis: A new tool for MDC1A research
Yoon, S., Stadler, G., Beermann, M. L., Schmidt, E. V., Windelborn, J. A., Schneiderat, P., Wright, W. E. & Miller, J. B., Dec 6 2013, In: Skeletal Muscle. 3, 1, 28.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells
Kim, S. B., Ly, P., Kaisani, A., Zhang, L., Wright, W. E. & Shay, J. W., Sep 2013, In: Radiation research. 180, 3, p. 259-267 9 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy
Wong, M. S., Chen, L., Foster, C., Kainthla, R., Shay, J. W. & Wright, W. E., Apr 25 2013, In: Cell Reports. 3, 4, p. 1028-1035 8 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy
Stadler, G., Rahimov, F., King, O. D., Chen, J. C. J., Robin, J. D., Wagner, K. R., Shay, J. W., Emerson, C. P. & Wright, W. E., Jun 2013, In: Nature Structural and Molecular Biology. 20, 6, p. 671-678 8 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
The roles of telomerase in the generation of polyploidy during neoplastic cell growth
Christodoulidou, A., Raftopoulou, C., Chiourea, M., Papaioannou, G. K., Hoshiyama, H., Wright, W. E., Shay, J. W. & Gagos, S., Feb 2013, In: Neoplasia (United States). 15, 2, p. 156-168 13 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2012
Development of methods for quantitative comparison of pooled shRNAs by mass sequencing
Hoshiyama, H., Tang, J., Batten, K., Xiao, G., Rouillard, J. M., Shay, J. W., Xie, Y. & Wright, W. E., Feb 2012, In: Journal of Biomolecular Screening. 17, 2, p. 258-265 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations