The Eugene McDermott Center for Human Growth and Development

2021

Eosinophilic esophagitis, Barrett's esophagus and esophageal neoplasms in the pediatric patient: A narrative review

Medina, A. L., Troendle, D. M., Park, J. Y., Thaker, A., Dunbar, K. B. & Cheng, E., Jul 2021, In: Translational Gastroenterology and Hepatology. 6, A19.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

Gene Transfer Therapy for Neurodevelopmental Disorders

Ozlu, C., Bailey, R. M., Sinnett, S. & Goodspeed, K. D., Sep 1 2021, In: Developmental Neuroscience. 43, 3, p. 230-240 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Scopus citations

Modern management of and update on prune belly syndrome

Lopes, R. I., Baker, L. A. & Dénes, F. T., Aug 2021, In: Journal of Pediatric Urology. 17, 4, p. 548-554 7 p.

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

2020

Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders

Fagiolini, M., Patrizi, A., LeBlanc, J., Jin, L. W., Maezawa, I., Sinnett, S., Gray, S. J., Molholm, S., Foxe, J. J., Johnston, M. V., Naidu, S., Blue, M., Hossain, A., Kadam, S., Zhao, X., Chang, Q., Zhou, Z. & Zoghbi, H., Oct 1 2020, In: Neuroscience. 445, p. 190-206 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

9 Scopus citations

Meeting report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: challenges and opportunities for translational research

Stadler, H. S., Peters, C. A., Sturm, R. M., Baker, L. A., Best, C. J. M., Bird, V. Y., Geller, F., Hoshizaki, D. K., Knudsen, T. B., Norton, J. M., Romao, R. L. P. & Cohn, M. J., Dec 2020, In: Journal of Pediatric Urology. 16, 6, p. 791-804 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

2019

Genomic testing in pediatric epilepsy

Thodeson, D. M. & Park, J. Y., 2019, In: Cold Spring Harbor Molecular Case Studies. 5, 4

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

Ischemic Mitral Regurgitation: Repair, Replacement or Nothing

Nonaka, D. F. & Fox, A. A., Mar 1 2019, In: Seminars in Cardiothoracic and Vascular Anesthesia. 23, 1, p. 11-19 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

2018

Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer

Wang, S., Ekoue, D. N., Raj, G. V. & Kittler, R., Dec 1 2018, In: Cancer Letters. 438, p. 86-96 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

2017

Mendelian Randomization: Using Natural Genetic Variation to Assess the Causal Role of Modifiable Risk Factors in Observational Studies

Neeland, I. J. & Kozlitina, J., Feb 21 2017, In: Circulation. 135, 8, p. 755-758 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

20 Scopus citations

The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies

Knudsen, E. S. & Witkiewicz, A. K., Jan 1 2017, In: Trends in Cancer. 3, 1, p. 39-55 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

186 Scopus citations

2016

Fundamentals of cancer metabolism

DeBerardinis, R. J. & Chandel, N. S., May 2016, In: Science Advances. 2, 5, e1600200.

Research output: Contribution to journal › Review article › peer-review

Open Access

1856 Scopus citations

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine

Knudsen, E. S., O'Reilly, E. M., Brody, J. R. & Witkiewicz, A. K., Jan 1 2016, In: Gastroenterology. 150, 1, p. 48-63 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

81 Scopus citations

Surgery in disorders of sex development (DSD) with a gender issue: If (why), when, and how?

Mouriquand, P. D. E., Gorduza, D. B., Gay, C. L., Meyer-Bahlburg, H. F. L., Baker, L., Baskin, L. S., Bouvattier, C., Braga, L., Caldamone, A. C., Duranteau, L., El Ghoneimi, A., Hensle, T. W., Hoebeke, P., Kaefer, M., Kalfa, N., Kolon, T. F., Manzoni, G., Mure, P. Y., Nordenskjöld, A., Pippi Salle, J. L., & 10 othersPoppas, D. P., Ransley, P. G., Rink, R. C., Rodrigo, R., Sann, L., Schober, J., Sibai, H., Wisniewski, A., Wolffenbuttel, K. P. & Lee, P., Jun 1 2016, In: Journal of Pediatric Urology. 12, 3, p. 139-149 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

167 Scopus citations

2015

Adipokines influence the inflammatory balance in autoimmunity

Hutcheson, J., Oct 1 2015, In: Cytokine. 75, 2, p. 272-279 8 p.

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

A homozygous loss-of-function variant in MYH11 in a case with megacystis-microcolon-intestinal hypoperistalsis syndrome

Gauthier, J., Ouled Amar Bencheikh, B., Hamdan, F. F., Harrison, S. M., Baker, L. A., Couture, F., Thiffault, I., Ouazzani, R., Samuels, M. E., Mitchell, G. A., Rouleau, G. A., Michaud, J. L. & Soucy, J. F., Sep 14 2015, In: European Journal of Human Genetics. 23, 9, p. 1266-1268 3 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

72 Scopus citations

A roadmap for interpreting ¹³C metabolite labeling patterns from cells

Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish, C. B., DeBerardinis, R. J., Feron, O., Frezza, C., Ghesquiere, B., Gottlieb, E., Hiller, K., Jones, R. G., Kamphorst, J. J., Kibbey, R. G., Kimmelman, A. C., Locasale, J. W., Lunt, S. Y., Maddocks, O. D. K., Malloy, C., & 17 othersMetallo, C. M., Meuillet, E. J., Munger, J., Nöh, K., Rabinowitz, J. D., Ralser, M., Sauer, U., Stephanopoulos, G., St-Pierre, J., Tennant, D. A., Wittmann, C., Vander Heiden, M. G., Vazquez, A., Vousden, K., Young, J. D., Zamboni, N. & Fendt, S. M., Aug 1 2015, In: Current Opinion in Biotechnology. 34, p. 189-201 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

439 Scopus citations

Ciliopathies and DNA damage: An emerging nexus

Attanasio, M., Jul 1 2015, In: Current opinion in nephrology and hypertension. 24, 4, p. 366-370 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Dysregulated metabolism contributes to oncogenesis

Target Validation Team, Dec 1 2015, In: Seminars in Cancer Biology. 35, p. S129-S150

Research output: Contribution to journal › Review article › peer-review

Open Access

219 Scopus citations

Metabolic dysregulation in monogenic disorders and cancer-finding method in madness

Erez, A. & Deberardinis, R. J., Jul 26 2015, In: Nature Reviews Cancer. 15, 7, p. 440-448 9 p.

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Metabolic pathways promoting cancer cell survival and growth

Boroughs, L. K. & Deberardinis, R. J., Apr 30 2015, In: Nature cell biology. 17, 4, p. 351-359 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1043 Scopus citations

Minireview: Familiar faces in unfamiliar places: The emerging role of nuclear receptors in lung cancer

Yenerall, P. & Kittler, R., Dec 2015, In: Molecular Endocrinology. 29, 12, p. 1675-1683 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

The history and future of targeting cyclin-dependent kinases in cancer therapy

Asghar, U., Witkiewicz, A. K., Turner, N. C. & Knudsen, E. S., Jan 1 2015, In: Nature Reviews Drug Discovery. 14, 2, p. 130-146 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1256 Scopus citations

2014

Retinoblastoma tumor suppressor pathway in breast cancer: Prognosis, precision medicine, and therapeutic interventions

Witkiewicz, A. K. & Knudsen, E. S., May 7 2014, In: Breast Cancer Research. 16, 2, 207.

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

2013

Long non-coding RNAs and complex human diseases

Li, J., Xuan, Z. & Liu, C., Sep 12 2013, In: International journal of molecular sciences. 14, 9, p. 18790-18808 19 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

168 Scopus citations

2011

Acinar cell carcinoma with prominent intraductal growth pattern: Case report and review of the literature

Toll, A. D., Mitchell, D., Yeo, C. J., Hruban, R. H. & Witkiewicz, A. K., Dec 2011, In: International Journal of Surgical Pathology. 19, 6, p. 795-799 5 p.

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Human fatty liver disease: Old questions and new insights

Cohen, J. C., Horton, J. D. & Hobbs, H. H., Jun 24 2011, In: Science. 332, 6037, p. 1519-1523 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1700 Scopus citations

The genetic components of idiopathic nephrolithiasis

Attanasio, M., Mar 2011, In: Pediatric Nephrology. 26, 3, p. 337-346 10 p.

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

The meaning of p16^ink4a expression in tumors: Functional significance, clinical associations and future developments

Witkiewicz, A. K., Knudsen, K. E., Dicker, A. P. & Knudsen, E. S., Aug 1 2011, In: Cell Cycle. 10, 15, p. 2497-2503 7 p.

Research output: Contribution to journal › Review article › peer-review

224 Scopus citations

The Past, Present, and Future of Biomarkers: A Need for Molecular Beacons for the Clinical Management of Pancreatic Cancer

Brody, J. R., Witkiewicz, A. K. & Yeo, C. J., Sep 2011, In: Advances in surgery. 45, 1, p. 301-321 21 p.

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

2010

Identifying pancreatic cancer patients for targeted treatment: The challenges and limitations of the current selection process and vision for the future

Showalter, S. L., Charles, S., Belin, J., Cozzitorto, J., Einstein, P., Richards, N. G., Sauter, P. K., Kennedy, E. P., Witkiewicz, A., Brody, J. R. & Yeo, C. J., Mar 2010, In: Expert Opinion on Drug Delivery. 7, 3, p. 273-284 12 p.

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Mendelian disorders and multifactorial traits: The big divide or one for all?

Antonarakis, S. E., Chakravarti, A., Cohen, J. C. & Hardy, J., May 2010, In: Nature Reviews Genetics. 11, 5, p. 380-384 5 p.

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

Martinez-Outschoorn, U. E., Whitaker-Menezes, D., Pavlides, S., Chiavarina, B., Bonuccelli, G., Trimmer, C., Tsirigos, A., Migneco, G., Witkiewicz, A. K., Balliet, R., Mercier, I., Wang, C., Flomenberg, N., Howell, A., Lin, Z., Caro, J., Pestell, R. G., Sotgia, F. & Lisanti, M. P., Nov 1 2010, In: Cell Cycle. 9, 21, p. 4297-4306 10 p.

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Understanding the "lethal" drivers of tumor-stroma co-evolution: Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

Lisanti, M. P., Martinez-Outschoorn, U. E., Chiavarina, B., Pavlides, S., Whitaker-Menezes, D., Tsirigos, A., Witkiewicz, A., Lin, Z., Balliet, R., Howell, A. & Sotgia, F., Sep 15 2010, In: Cancer Biology and Therapy. 10, 6, p. 537-542 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

167 Scopus citations

2009

Effect of genetic factors on opioid action

Kosarac, B., Fox, A. A. & Collard, C. D., Aug 2009, In: Current opinion in anaesthesiology. 22, 4, p. 476-482 7 p.

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma

Lavu, H., Mascaro, A. A., Grenda, D. R., Sauter, P. K., Leiby, B. E., Croker, S. P., Witkiewicz, A., Berger, A. C., Rosato, E. L., Kennedy, E. P. & Yeo, C. J., 2009, In: Journal of Gastrointestinal Surgery. 13, 11, p. 1937-1947 11 p.

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

PCSK9: A convertase that coordinates LDL catabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Apr 2009, In: Journal of lipid research. 50, SUPPL., p. S172-S177

Research output: Contribution to journal › Review article › peer-review

514 Scopus citations

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

Witkiewicz, A. K., Casimiro, M. C., Dasgupta, A., Mercier, I., Wang, C., Bonuccelli, G., Jasmin, J. F., Frank, P. G., Pestell, R. G., Kleer, C. G., Sotgia, F. & Lisanti, M. P., Jun 1 2009, In: Cell Cycle. 8, 11, p. 1654-1658 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

54 Scopus citations

2008

Systems biology of mammalian cell division

Kittler, R., Pelletier, L. & Buchholz, F., Jul 15 2008, In: Cell Cycle. 7, 14, p. 2123-2128 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

2007

Molecular biology of PCSK9: its role in LDL metabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Feb 2007, In: Trends in biochemical sciences. 32, 2, p. 71-77 7 p.

Research output: Contribution to journal › Review article › peer-review

491 Scopus citations

The complex array of nephronophthisis

Attanasio, M., Dec 2007, In: Italian Journal of Pediatrics. 33, 6, p. 305-308 4 p.

Research output: Contribution to journal › Review article › peer-review

2006

Efficient survey sampling of households via Gaussian quadrature

Arndt, C., Kozlitina, J. & Preckel, P. V., May 2006, In: Journal of the Royal Statistical Society. Series C: Applied Statistics. 55, 3, p. 355-364 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

Enzymatically prepared RNAi libraries

Buchholz, F., Kittler, R., Slabicki, M. & Theis, M., Sep 2006, In: Nature methods. 3, 9, p. 696-700 5 p.

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Genetic Approaches to Coronary Heart Disease

Cohen, J. C., Nov 7 2006, In: Journal of the American College of Cardiology. 48, 9 SUPPL., p. A10-A14

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Influence of Statins on Perioperative Outcomes

Hindler, K., Eltzschig, H. K., Fox, A. A., Body, S. C., Shernan, S. K. & Collard, C. D., Apr 2006, In: Journal of cardiothoracic and vascular anesthesia. 20, 2, p. 251-258 8 p.

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

2005

Eine Genom-weite RNA-Interferenz-Bibliothek für die funktionelle Charakterisierung aller Gene in kultivierten, menschlichen Zellen

Translated title of the contribution: A genome-wide RNA interference library for the functional characterization of all genes in cuttured human cellsKrauß, E., Heninger, A. K., Kittler, R., Lohmann, A., Poser, I., Wagner, J., Franke, K., Kozak, K., Grabner, H. & Buchholz, F., 2005, In: BioSpektrum. 11, 4, p. 436-441 6 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations