Research output per year
Research output per year
- 1 - 50 out of 74 results
Search results
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2018
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis
Lu, H., Fermaintt, C. S., Cherepanova, N. A., Reid, G., Yan, N. & Lehrman, M. A., Sep 18 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9557-9562 6 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2016
Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells
Lopez-Sambrooks, C., Shrimal, S., Khodier, C., Flaherty, D. P., Rinis, N., Charest, J. C., Gao, N., Zhao, P., Wells, L., Lewis, T. A., Lehrman, M. A., Gilmore, R., Golden, J. E. & Contessa, J. N., Dec 1 2016, In: Nature chemical biology. 12, 12, p. 1023-1030 8 p.Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
Trappc11 is required for protein glycosylation in zebrafish and humans
DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C., Apr 15 2016, In: Molecular biology of the cell. 27, 8, p. 1220-1234 15 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2015
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation
Hasan, M., Fermaintt, C. S., Gao, N., Sakai, T., Miyazaki, T., Jiang, S., Li, Q. Z., Atkinson, J. P., Morse, H. C., Lehrman, M. A. & Yan, N., Sep 15 2015, In: Immunity. 43, 3, p. 463-474 12 p., 3143.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress
Leclerc, G. J., DeSalvo, J., Du, J., Gao, N., Leclerc, G. M., Lehrman, M. A., Lampidis, T. J. & Barredo, J. C., May 13 2015, In: Leukemia Research. 39, 11, p. 1246-1254 9 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2014
Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose
Philips, K. B., Kurtoglu, M., Leung, H. J., Liu, H., Gao, N., Lehrman, M. A., Murray, T. G. & Lampidis, T. J., Feb 2014, In: Cancer Chemotherapy and Pharmacology. 73, 2, p. 349-361 13 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
Wang, Z., Deng, Y., Gao, N., Pedrozo, Z., Li, D. L., Morales, C. R., Criollo, A., Luo, X., Tan, W., Jiang, N., Lehrman, M. A., Rothermel, B. A., Lee, A. H., Lavandero, S., Mammen, P. P., Ferdous, A., Gillette, T. G., Scherer, P. E. & Hill, J. A., Mar 13 2014, In: Cell. 156, 6, p. 1179-1192 14 p.Research output: Contribution to journal › Article › peer-review
300 Scopus citations -
2013
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Chu, J., Mir, A., Gao, N., Rosa, S., Monson, C., Sharma, V., Steet, R., Freeze, H. H., Lehrman, M. A. & Sadler, K. C., Jan 2013, In: DMM Disease Models and Mechanisms. 6, 1, p. 95-105 11 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1
Jelk, J., Gao, N., Serricchio, M., Signorell, A., Schmidt, R. S., Bangs, J. D., Acosta-Serrano, A., Lehrman, M. A., Bütikofer, P. & Menon, A. K., Jul 12 2013, In: Journal of Biological Chemistry. 288, 28, p. 20616-20623 8 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant non-small cell lung cancer
Bennett, D. C., Charest, J., Sebolt, K., Lehrman, M., Rehemtulla, A. & Contessa, J. N., 2013, In: Translational Oncology. 6, 3, p. 382-391 10 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
Deng, Y., Wang, Z., Tao, C., Gao, N., Holland, W. L., Ferdous, A., Repa, J., Liang, G., Ye, J., Lehrman, M. A., Hill, J. A., Horton, J. D. & Scherer, P. E., Jan 2 2013, In: Journal of Clinical Investigation. 123, 1, p. 455-468 14 p.Research output: Contribution to journal › Article › peer-review
111 Scopus citations -
2012
5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation
Zandberg, W. F., Gao, N., Kumarasamy, J., Lehrman, M. A., Seidah, N. G. & Pinto, B. M., Feb 13 2012, In: ChemBioChem. 13, 3, p. 392-401 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency
Cline, A., Gao, N., Flanagan-Steet, H., Sharma, V., Rosa, S., Sonon, R., Azadi, P., Sadler, K. C., Freeze, H. H., Lehrman, M. A. & Steet, R., Nov 1 2012, In: Molecular biology of the cell. 23, 21, p. 4175-4187 13 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
2011
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides
Gao, N., Shang, J., Huynh, D., Manthati, V. L., Arias, C., Harding, H. P., Kaufman, R. J., Mohr, I., Ron, D., Falck, J. R. & Lehrman, M. A., Sep 1 2011, In: Molecular biology of the cell. 22, 17, p. 2994-3009 16 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation
Harrison, K. D., Park, E. J., Gao, N., Kuo, A., Rush, J. S., Waechter, C. J., Lehrman, M. A. & Sessa, W. C., May 2011, In: EMBO Journal. 30, 12, p. 2490-2500 11 p.Research output: Contribution to journal › Article › peer-review
91 Scopus citations -
2010
Antiangiogenic activity of 2-deoxy-D-glucose
Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoglu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A. & Lampidis, T. J., 2010, In: PloS one. 5, 10, e13699.Research output: Contribution to journal › Article › peer-review
96 Scopus citations -
2009
Suppression of Rft1 expression does not impair the transbilayer movement of Man5GlcNAc2-P-P-dolichol in sealed microsomes from yeast
Rush, J. S., Gao, N., Lehrman, M. A., Matveev, S. & Waechter, C. J., Jul 24 2009, In: Journal of Biological Chemistry. 284, 30, p. 19835-19842 8 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
2008
Recycling of dolichyl monophosphate to the cytoplasmic leaflet of the endoplasmic reticulum after the cleavage of dolichyl pyrophosphate on the lumenal monolayer
Rush, J. S., Gao, N., Lehrman, M. A. & Waechter, C. J., Feb 15 2008, In: Journal of Biological Chemistry. 283, 7, p. 4087-4093 7 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Unexpected basis for impaired Glc3Man9 GlcNAc2-P-P-dolichol biosynthesis by elevated expression of GlcNAc-1-P transferase
Gao, N., Shang, J. & Lehrman, M. A., Jan 2008, In: Glycobiology. 18, 1, p. 125-134 10 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2007
Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux
Shang, J., Gao, N., Kaufman, R. J., Ron, D., Harding, H. P. & Lehrman, M. A., Feb 26 2007, In: Journal of Cell Biology. 176, 5, p. 605-616 12 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation
Kurtoglu, M., Gao, N., Shang, J., Maher, J. C., Lehrman, M. A., Wangpaichitr, M., Savaraj, N., Lane, A. N. & Lampidis, T. J., Nov 1 2007, In: Molecular Cancer Therapeutics. 6, 11, p. 3049-3058 10 p.Research output: Contribution to journal › Article › peer-review
196 Scopus citations -
2006
Non-Radioactive Analysis of Lipid-Linked Oligosaccharide Compositions by Fluorophore-Assisted Carbohydrate Electrophoresis
Gao, N. & Lehrman, M. A., 2006, In: Methods in Enzymology. 415, p. 3-20 18 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2005
Analysis of glycosylation in CDG-Ia fibroblasts by fluorophore-assisted carbohydrate electrophoresis: Implications for extracellular glucose and intracellular mannose 6-phosphate
Gao, N., Shang, J. & Lehrman, M. A., May 6 2005, In: Journal of Biological Chemistry. 280, 18, p. 17901-17909 9 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease
Cho, S. K., Gao, N., Pearce, D. A., Lehrman, M. A. & Hofmann, S. L., 2005, In: Glycobiology. 15, 6, p. 637-648 12 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2004
Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR): Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates
Shang, J. & Lehrman, M. A., Mar 26 2004, In: Journal of Biological Chemistry. 279, 13, p. 12076-12080 5 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts
Shang, J. & Lehrman, M. A., Apr 30 2004, In: Biochemical and Biophysical Research Communications. 317, 2, p. 390-396 7 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Inhibition of mammalian RNA synthesis by the cytoplasmic Ca2+ buffer BAPTA. Analyses of [3H]uridine incorporation and stress-dependent transcription
Shang, J. & Lehrman, M. A., Jul 27 2004, In: Biochemistry. 43, 29, p. 9576-9582 7 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Metformin-stimulated Mannose Transport in Dermal Fibroblasts
Shang, J. & Lehrman, M. A., Mar 12 2004, In: Journal of Biological Chemistry. 279, 11, p. 9703-9712 10 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
2003
Alternative and sources of reagents and supplies of fluorophore-assisted carbohydrate electrophoresis(FACE).
Lehrman, M. A. & Gao, N., Jan 2003, In: Glycobiology. 13, 1, p. 1G-3GResearch output: Contribution to journal › Article › peer-review
9 Scopus citations -
2002
Analyses of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues by fluorophore-assisted carbohydrate electrophoresis
Gao, N. & Lehrman, M. A., 2002, In: Glycobiology. 12, 5, p. 353-360 8 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Coupling of the dolichol-P-P-oligosaccharide pathway to translation by perturbation-sensitive regulation of the initiating enzyme, GlcNAc-1-P transferase
Gao, N. & Lehrman, M. A., Oct 18 2002, In: Journal of Biological Chemistry. 277, 42, p. 39425-39435 11 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Extension of lipid-linked oligosaccharides is a high-priority aspect of the unfolded protein response: Endoplasmic reticulum stress in Type I congenital disorder of glycosylation fibroblasts
Shang, J., Körner, C., Freeze, H. & Lehrman, M. A., 2002, In: Glycobiology. 12, 5, p. 307-317 11 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Rapid activation of glycogen phosphorylase by the endoplasmic reticulum unfolded protein response
Gill, A., Gao, N. & Lehrman, M. A., Nov 22 2002, In: Journal of Biological Chemistry. 277, 47, p. 44747-44753 7 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
2001
A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)
Kranz, C., Denecke, J., Lehrman, M. A., Ray, S., Kienz, P., Kreissel, G., Sagi, D., Peter-Katalinic, J., Freeze, H. H., Schmid, T., Jackowski-Dohrmann, S., Harms, E. & Marquardt, T., 2001, In: Journal of Clinical Investigation. 108, 11, p. 1613-1619 7 p.Research output: Contribution to journal › Article › peer-review
Open Access112 Scopus citations -
Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals
Anand, M., Rush, J. S., Ray, S., Doucey, M. A., Weik, J., Ware, F. E., Hofsteenge, J., Waechter, C. J. & Lehrman, M. A., 2001, In: Molecular biology of the cell. 12, 2, p. 487-501 15 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
2000
A water-soluble analogue of glucosaminylphosphatidylinositol distinguishes two activities that palmitoylate inositol on GPI anchors
Doerrler, W. T. & Lehrman, M. A., Jan 7 2000, In: Biochemical and Biophysical Research Communications. 267, 1, p. 296-299 4 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
1999
Regulation of the dolichol pathway in human fibroblasts by the endoplasmic reticulum unfolded protein response
Doerrler, W. T. & Lehrman, M. A., Nov 9 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 23, p. 13050-13055 6 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
1998
Conserved sequences in enzymes of the UDP-GlcNAc/MurNAc family are essential in hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase
Dal Nogare, A. R., Dan, N. & Lehrman, M. A., Jun 1998, In: Glycobiology. 8, 6, p. 625-632 8 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells.
Ware, F. E. & Lehrman, M. A., May 22 1998, In: The Journal of biological chemistry. 273, 21, p. 13366 1 p.Research output: Contribution to journal › Article › peer-review
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Oligosaccharide binding characteristics of the molecular chaperones calnexin and calreticulin
Vassilakos, A., Michalak, M., Lehrman, M. A. & Williams, D. B., Mar 10 1998, In: Biochemistry. 37, 10, p. 3480-3490 11 p.Research output: Contribution to journal › Article › peer-review
233 Scopus citations -
1997
Oligomerization of hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase, an enzyme with multiple transmembrane spans
Dan, N. & Lehrman, M. A., May 30 1997, In: Journal of Biological Chemistry. 272, 22, p. 14214-14219 6 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
1996
Acylation of glucosaminyl phosphatidylinositol revisited. Palmitoyl-CoA dependent palmitoylation of the inositol residue of a synthetic dioctanoyl glucosaminyl phosphatidylinositol by hamster membranes permits efficient mannosylation of the glucosamine residue
Doerrler, W. T., Ye, J., Falck, J. R. & Lehrman, M. A., 1996, In: Journal of Biological Chemistry. 271, 43, p. 27031-27038 8 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells
Ware, F. E. & Lehrman, M. A., 1996, In: Journal of Biological Chemistry. 271, 24, p. 13935-13938 4 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs
Ye, J., Doerrler, W. T., Lehrman, M. A. & Falck, J. R., Jul 23 1996, In: Bioorganic and Medicinal Chemistry Letters. 6, 14, p. 1715-1718 4 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Hamster UDP-N-acetylglucosamine:dolichol-P N-acetylglucosamine-1-P transferase has multiple transmembrane spans and a critical cytosolic loop
Dan, N., Middleton, R. B. & Lehrman, M. A., 1996, In: Journal of Biological Chemistry. 271, 48, p. 30717-30724 8 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
Mannosylation of a synthetic gpi precursor by hamster membranes requires prior palmttoyl-CoA dependent acylation
Doerrier, W. T., Ye, J., Falck, J. R. & Lehrman, M. A., 1996, In: FASEB Journal. 10, 6, p. A1108Research output: Contribution to journal › Article › peer-review
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1995
The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins
Ware, F. E., Vassilakos, A., Peterson, P. A., Jackson, M. R., Lehrman, M. A. & Williams, D. B., Mar 3 1995, In: Journal of Biological Chemistry. 270, 9, p. 4697-4704 8 p.Research output: Contribution to journal › Article › peer-review
392 Scopus citations -
1994
Mannolipid donor specificity of glycosylphosphatidylinositol mannosyltransferase-I (GPIMT-I) determined with an assay system utilizing mutant CHO-K1 cells
Deluca, A. W., Rush, J. S., Lehrman, M. A. & Waechter, C. J., Dec 1994, In: Glycobiology. 4, 6, p. 909-915 7 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Role of the carboxyl terminus in stable expression of hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase
Zara, J. & Lehrman, M. A., Jul 22 1994, In: Journal of Biological Chemistry. 269, 29, p. 19108-19115 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
1993
Both potential dolichol recognition sequences of hamster GlcNAc-1-phosphate transferase are necessary for normal enzyme function
Datta, A. K. & Lehrman, M. A., Jun 15 1993, In: Journal of Biological Chemistry. 268, 17, p. 12663-12668 6 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations