Pharmacology - Goodman Lab – Research output — University of Texas Southwestern Medical Center

2023

Fatty Acyl Coenzyme A Synthetase Fat1p Regulates Vacuolar Structure and Stationary-Phase Lipophagy in Saccharomyces cerevisiae

Qiu, F., Kang, N., Tan, J., Yan, S., Lin, L., Cai, L., Goodman, J. M. & Gao, Q., Jan 2023, In: Microbiology Spectrum. 11, 1

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

Seipin forms a flexible cage at lipid droplet formation sites

Arlt, H., Sui, X., Folger, B., Adams, C., Chen, X., Remme, R., Hamprecht, F. A., DiMaio, F., Liao, M., Goodman, J. M., Farese, R. V. & Walther, T. C., Mar 2022, In: Nature Structural and Molecular Biology. 29, 3, p. 194-202 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2017

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

Gao, Q., Binns, D. D., Kinch, L. N., Grishin, N. V., Ortiz, N., Chen, X. & Goodman, J. M., Oct 1 2017, In: Journal of Cell Biology. 216, 10, p. 3199-3217 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

2015

Arabidopsis SEIPIN proteins modulate triacylglycerol accumulation and influence lipid droplet proliferation

Cai, Y., Goodman, J. M., Pyc, M., Mullen, R. T., Dyer, J. M. & Chapmana, K. D., 2015, In: Plant Cell. 27, 9, p. 2616-2636 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

122 Scopus citations

Dissecting seipin function: The localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p^ΔNterm only in combination with Ldb16p

Han, S., Binns, D. D., Chang, Y. F. & Goodman, J. M., Dec 4 2015, In: BMC Cell Biology. 16, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

Cartwright, B. R., Binns, D. D., Hilton, C. L., Han, S., Gao, Q. & Goodman, J. M., Feb 15 2015, In: Molecular biology of the cell. 26, 4, p. 726-739 14 p.

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

2012

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway

Han, S., Bahmanyar, S., Zhang, P., Grishin, N., Oegema, K., Crooke, R., Graham, M., Reue, K., Dixon, J. E. & Goodman, J. M., Jan 27 2012, In: Journal of Biological Chemistry. 287, 5, p. 3123-3137 15 p.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

2011

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

Adeyo, O., Horn, P. J., Lee, S., Binns, D. D., Chandrahas, A., Chapman, K. D. & Goodman, J. M., Mar 21 2011, In: Journal of Cell Biology. 192, 6, p. 1043-1055 13 p.

Research output: Contribution to journal › Article › peer-review

228 Scopus citations

2010

Seipin is a discrete homooligomer

Binns, D., Lee, S., Hilton, C. L., Jiang, Q. X. & Goodman, J. M., Dec 21 2010, In: Biochemistry. 49, 50, p. 10747-10755 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

2007

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

Szymanski, K. M., Binns, D., Bartz, R., Grishin, N. V., Li, W. P., Agarwal, A. K., Garg, A., Anderson, R. G. W. & Goodman, J. M., Dec 26 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20890-20895 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

484 Scopus citations

2006

An intimate collaboration between peroxisomes and lipid bodies

Binns, D., Januszewski, T., Chen, Y., Hill, J., Markin, V. S., Zhao, Y., Gilpin, C., Chapman, K. D., Anderson, R. G. W. & Goodman, J. M., Jun 5 2006, In: Journal of Cell Biology. 173, 5, p. 719-731 13 p.

Research output: Contribution to journal › Article › peer-review

296 Scopus citations

2004

Multiple Targeting Modules on Peroxisomal Proteins Are Not Redundant: Discrete Functions of Targeting Signals within Pmp47 and Pex8p

Wang, X., McMahon, M. A., Shelton, S. N., Nampaisansuk, M., Ballard, J. L. & Goodman, J. M., Apr 2004, In: Molecular biology of the cell. 15, 4, p. 1702-1710 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2003

Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase

Shelton, S. N., Barylko, B., Binns, D. D., Horazdovsky, B. F., Albanesi, J. P. & Goodman, J. M., Apr 15 2003, In: Biochemical Journal. 371, 2, p. 533-540 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2002

Monomeric alcohol oxidase is preferentially digested by a novel protease from Candida boidinii

Stewart, M. Q., Van Dijk, R., Veenhuis, M. & Goodman, J. M., Jan 30 2002, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1542, 1-3, p. 160-172 13 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2001

Alcohol oxidase and dihydroxyacetone synthase, the abundant peroxisomal proteins of methylotrophic yeasts, assemble in different cellular compartments

Stewart, M. Q., Esposito, R. D., Gowani, J. & Goodman, J. M., 2001, In: Journal of cell science. 114, 15, p. 2863-2868 6 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Discrete Targeting Signals Direct Pmp47 to Oleate-induced Peroxisomes in Saccharomyces cerevisiae

Wang, X., Unruh, M. J. & Goodman, J. M., Apr 6 2001, In: Journal of Biological Chemistry. 276, 14, p. 10897-10905 9 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

1996

Redox-sensitive homodimerization of Pex11p: A proposed mechanism to regulate peroxisomal division

Marshall, P. A., Dyer, J. M., Quick, M. E. & Goodman, J. M., Oct 1996, In: Journal of Cell Biology. 135, 1, p. 123-137 15 p.

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop

Dyer, J. M., McNew, J. A. & Goodman, J. M., Apr 1996, In: Journal of Cell Biology. 133, 2, p. 269-280 12 p.

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

The targeting and assembly of peroxisomal proteins: Some old rules do not apply

McNew, J. A. & Goodman, J. M., Feb 1996, In: Trends in Biochemical Sciences. 21, 2, p. 54-58 5 p.

Research output: Contribution to journal › Article › peer-review

1995

Pmp27 promotes peroxisomal proliferation

Marshall, P. A., Krimkevich, Y. I., Lark, R. H., Dyer, J. M., Veenhuis, M. & Goodman, J. M., Apr 1995, In: Journal of Cell Biology. 129, 2, p. 345-355 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

The Candida boidinii peroxisomal membrane protein Pmp30 has a role in peroxisomal proliferation and is functionally homologous to Pmp27 from Saccharomyces cerevisiae

Sakai, Y., Marshall, P. A., Saiganji, A., Takabe, K., Saiki, H., Kato, N. & Goodman, J. M., 1995, In: Journal of bacteriology. 177, 23, p. 6773-6781 9 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

1994

An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes

McCammon, M. T., McNew, J. A., Willy, P. J. & Goodman, J. M., Mar 1994, In: Journal of Cell Biology. 124, 6, p. 915-925 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

An oligomeric protein is imported into peroxisomes in vivo

McNew, J. A. & Goodman, J. M., Dec 1994, In: Journal of Cell Biology. 127, 5, p. 1245-1257 13 p.

Research output: Contribution to journal › Article › peer-review

285 Scopus citations

The peroxisomal membrane proteins of Candida boidinii: Gene isolation and expression

Moreno, M., Lark, R., Campbell, K. L. & Goodman, J. M., Nov 1994, In: Yeast. 10, 11, p. 1447-1457 11 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

1993

Expression and targeting of a 47 kDa integral peroxisomal membrane protein of Candida boidinii in wild type and a peroxisome-deficient mutant of Hansenula polymorpha

Sulter, G. J., Waterham, H. R., Vrieling, E. G., Goodman, J. M., Harder, W. & Veenhius, M., Jan 11 1993, In: FEBS Letters. 315, 3, p. 211-216 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Specific cross-linking of the proline isomerase cyclophilin to a non-proline-containing peptide

McNew, J. A., Sykes, K. & Goodman, J. M., 1993, In: Molecular biology of the cell. 4, 2, p. 223-232 10 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

1992

Chapter 16 Structure and assembly of peroxisomal membrane proteins

Goodman, J. M., Garrard, L. J. & McCammon, M. T., 1992, In: New Comprehensive Biochemistry. 22, C, p. 209-220 12 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Development of multipurpose peroxisomes in Candida boidinii grown in oleic acid-methanol limited continuous cultures

Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W. & Veenhuis, M., 1992, In: Journal of bacteriology. 174, 12, p. 4057-4063 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

1990

Association of glyoxylate and beta-oxidation enzymes with peroxisomes of Saccharomyces cerevisiae

McCammon, M. T., Veenhuis, M., Trapp, S. B. & Goodman, J. M., 1990, In: Journal of bacteriology. 172, 10, p. 5816-5827 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Immunocytochemical evidence for the acidic nature of peroxisomes in methylotrophic yeasts

Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W. & Veenhuis, M., Mar 12 1990, In: FEBS Letters. 262, 1, p. 17-19 3 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Peroxisomal assembly: Membrane proliferation precedes the induction of the abundant matrix proteins in the methylotrophic yeast Candida boidinii

Veenhuis, M. & Goodman, J. M., Aug 1990, In: Journal of cell science. 96, 4, p. 583-590 8 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Peroxisomal protein import is conserved between yeast, plants, insects and mammals

Gould, S. J., Keller, G. A., Schneider, M., Howell, S. H., Garrard, L. J., Goodman, J. M., Distel, B., Tabak, H. & Subramani, S., 1990, In: EMBO Journal. 9, 1, p. 85-90 6 p.

Research output: Contribution to journal › Article › peer-review

260 Scopus citations

Peroxisomes induced in Candida boidinii by methanol, oleic acid and D-alanine vary in metabolic function but share common integral membrane proteins

Goodman, J. M., Trapp, S. B., Hwang, H. & Veenhuis, M., Sep 1990, In: Journal of cell science. 97, 1, p. 193-204 12 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Proliferation and metabolic significance of peroxisomes in Candida boidinii during growth on d-alanine or oleic acid as the sole carbon source

Sulter, G. J., Waterham, H. R., Goodman, J. M. & Veenhuis, M., Apr 1990, In: Archives of Microbiology. 153, 5, p. 485-489 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae

McCammon, M. T., Dowds, C. A., Orth, K., Moomaw, C. R., Slaughter, C. A. & Goodman, J. M., Nov 25 1990, In: Journal of Biological Chemistry. 265, 33, p. 20098-20105 8 p.

Research output: Contribution to journal › Article › peer-review