Cell Biology - Division H – Research output — University of Texas Southwestern Medical Center

2023

GPR84-mediated signal transduction affects metabolic function by promoting brown adipocyte activity

Sun, X. N., An, Y. A., Paschoal, V. A., de Souza, C. O., Wang, M. Y., Vishvanath, L., Bueno, L. M. A., Cobb, A. S., Nieto Carrion, J. A., Ibe, M. E., Li, C., Kidd, H. A., Chen, S., Li, W., Gupta, R. K. & Oh, D. Y., Dec 1 2023, In: Journal of Clinical Investigation. 133, 24, e168992.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

Wang, Z., Yemanyi, F., Blomfield, A. K., Bora, K., Huang, S., Liu, C. H., Britton, W. R., Cho, S. S., Tomita, Y., Fu, Z., Ma, J. X., Li, W. H. & Chen, J., 2022, In: eLife. 11, e73105.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2021

In Vivo ZIMIR Imaging of Mouse Pancreatic Islet Cells Shows Oscillatory Insulin Secretion

Chen, S., Huang, Z. J., Kidd, H., Kim, M., Suh, E. H., Xie, S., Ghazvini Zadeh, E. H., Xu, Y., Sherry, A. D., Scherer, P. E. & Li, W. H., Mar 9 2021, In: Frontiers in Endocrinology. 12, 613964.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions

Onodera, T., Zadeh, E. G., Xu, P., Gordillo, R., Guo, Z., Joffin, N., Yu, B., Scherer, P. E. & Li, W. H., Jun 1 2021, In: Journal of lipid research. 62, 100095.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2020

Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose

Bosma, K. J., Rahim, M., Singh, K., Goleva, S. B., Wall, M. L., Xia, J., Syring, K. E., Oeser, J. K., Poffenberger, G., McGuinness, O. P., Means, A. L., Powers, A. C., Li, W. H., Davis, L. K., Young, J. D. & O’Brien, R. M., 2020, In: Journal of molecular endocrinology. 64, 4, p. 235-248 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Research methodology for in vivo measurements of resting energy expenditure, daily body temperature, metabolic heat and non-viral tissue-specific gene therapy in baboons

Frost, P. A., Chen, S., Rodriguez-Ayala, E., Laviada-Molina, H. A., Vaquera, Z., Gaytan-Saucedo, J. F., Li, W. H., Haack, K., Grayburn, P. A., Sayers, K., Cole, S. A. & Bastarrachea, R. A., Dec 2020, In: Research in Veterinary Science. 133, p. 136-145 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

ZIGIR, a Granule-Specific Zn²⁺ Indicator, Reveals Human Islet α Cell Heterogeneity

Ghazvini Zadeh, E. H., Huang, Z. J., Xia, J., Li, D., Davidson, H. W. & Li, W. H., Jul 14 2020, In: Cell Reports. 32, 2, 107904.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2017

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In: Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells

Xu, Y., Chen, Y., Li, D., Liu, Q., Xuan, Z. & Li, W. H., Feb 1 2017, In: RNA Biology. 14, 2, p. 259-274 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2016

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In: Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Molecular genetic regulation of Slc30a8/ZnT8 reveals a positive association with glucose tolerance

Mitchell, R. K., Hu, M., Chabosseau, P. L., Cane, M. C., Meur, G., Bellomo, E. A., Carzaniga, R., Collinson, L. M., Li, W. H., Hodson, D. J. & Rutter, G. A., Jan 2016, In: Molecular Endocrinology. 30, 1, p. 77-91 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate

Jordan, M. V. C., Lo, S. T., Chen, S., Preihs, C., Chirayil, S., Zhang, S., Kapur, P., Li, W. H., De Leon-Rodriguez, L. M., Lubag, A. J. M., Rofsky, N. M. & Sherry, A. D., Sep 13 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5464-E5471

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

2015

Genetic targeting of a small fluorescent zinc indicator to cell surface for monitoring zinc secretion

Li, D., Liu, L. & Li, W. H., Apr 17 2015, In: ACS chemical biology. 10, 4, p. 1054-1063 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

GLP-1 Receptor Mediated Targeting of a Fluorescent Zn²⁺ Sensor to Beta Cell Surface for Imaging Insulin/Zn²⁺ Release

Li, D., Huang, Z., Chen, S., Hu, Z. & Li, W. H., Aug 19 2015, In: Bioconjugate Chemistry. 26, 8, p. 1443-1450 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2014

ADCY5 couples glucose to insulin secretion in human islets

Hodson, D. J., Mitchell, R. K., Marselli, L., Pullen, T. J., Brias, S. G., Semplici, F., Everett, K. L., Cooper, D. M. F., Bugliani, M., Marchetti, P., Lavallard, V., Bosco, D., Piemonti, L., Johnson, P. R., Hughes, S. J., Li, D., Li, W. H., Shapiro, A. M. J. & Rutter, G. A., Sep 2014, In: Diabetes. 63, 9, p. 3009-3021 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

2013

Improved orange and red Ca²⁺ indicators and photophysical considerations for optogenetic applications

Wu, J., Liu, L., Matsuda, T., Zhao, Y., Rebane, A., Drobizhev, M., Chang, Y. F., Araki, S., Arai, Y., March, K., Hughes, T. E., Sagou, K., Miyata, T., Nagai, T., Li, W. H. & Campbell, R. E., Jun 19 2013, In: ACS Chemical Neuroscience. 4, 6, p. 963-972 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

165 Scopus citations

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W. H., Bugliani, M., Marchetti, P., Bosco, D., Piemonti, L., Johnson, P., Hughes, S. J. & Rutter, G. A., Oct 1 2013, In: Journal of Clinical Investigation. 123, 10, p. 4182-4194 13 p.

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

2012

Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans

Schumacher, J. A., Hsieh, Y. W., Chen, S., Pirri, J. K., Alkema, M. J., Li, W. H., Chang, C. & Chuang, C. F., Nov 15 2012, In: Development (Cambridge). 139, 22, p. 4191-4201 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2011

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)

Li, D., Chen, S., Bellomo, E. A., Tarasov, A. I., Kaut, C., Rutter, G. A. & Li, W. H., Dec 27 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21063-21068 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

123 Scopus citations

Temporal and spatial regulation of microrna activity with photoactivatable cantimirs

Zheng, G., Cochella, L., Liu, J., Hobert, O. & Li, W. H., Dec 2011, In: ACS chemical biology. 6, 12, p. 1332-1338 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2010

Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent

Zheng, G., Ambros, V. & Li, W. H., Apr 1 2010, In: Silence. 1, 1, 9.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Photo-activatable probes for the analysis of receptor function in living cells.

Li, W. H., 2010, In: Methods in molecular biology (Clifton, N.J.). 591, p. 105-120 16 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2009

Assaying dynamic cell-cell junctional communication using noninvasive and quantitative fluorescence imaging techniques: LAMP and infrared-LAMP

Yang, S. & Li, W. H., 2009, In: Nature Protocols. 4, 1, p. 94-101 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells

Wu, Z., Luby-Phelps, K., Bugde, A., Molyneux, L. A., Denard, B., Li, W. H., Süel, G. M. & Garbers, D. L., Nov 16 2009, In: Journal of Cell Biology. 187, 4, p. 513-524 12 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Versatile synthesis and rational design of caged morpholinos

Ouyang, X., Shestopalov, I. A., Sinha, S., Zheng, G., Pitt, C. L. W., Li, W. H., Olson, A. J. & Chen, J. K., Sep 23 2009, In: Journal of the American Chemical Society. 131, 37, p. 13255-13269 15 p.

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

2008

Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Guo, Y. M., Chen, S., Shetty, P., Zheng, G., Lin, R. & Li, W. H., 2008, In: Nature methods. 5, 9, p. 835-841 7 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

2007

Cell membrane permeable esters of d-myo-inositol 1,4,5-trisphosphate

Dakin, K. & Li, W. H., Sep 2007, In: Cell Calcium. 42, 3, p. 291-301 11 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic

Bartz, R., Li, W. H., Venables, B., Zehmer, J. K., Roth, M. R., Welti, R., Anderson, R. G. W., Liu, P. & Chapman, K. D., Apr 2007, In: Journal of lipid research. 48, 4, p. 837-847 11 p.

Research output: Contribution to journal › Article › peer-review

370 Scopus citations

Photoactivatable and water soluble FRET dyes with high uncaging cross section

Zheng, G., Guo, Y. M. & Li, W. H., Sep 5 2007, In: Journal of the American Chemical Society. 129, 35, p. 10616-10617 2 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

2006

Local Ca²⁺ rise near store operated Ca²⁺ channels inhibits cell coupling during capacitative Ca²⁺ influx

Dakin, K. & Li, W. H., Jan 2006, In: Cell Communication and Adhesion. 13, 1-2, p. 29-39 11 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2005

A cAMP and Ca²⁺ coincidence detector in support of Ca²⁺-induced Ca²⁺ release in mouse pancreatic β cells

Kang, G., Chepurny, O. G., Rindler, M. J., Collis, L., Chepurny, Z., Li, W. H., Harbeck, M., Roe, M. W. & Holz, G. G., Jul 1 2005, In: Journal of Physiology. 566, 1, p. 173-188 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Scopus citations

A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications

Zheng, Q., Dai, H., Merritt, M. E., Malloy, C., Pan, C. Y. & Li, W. H., Nov 23 2005, In: Journal of the American Chemical Society. 127, 46, p. 16178-16188 11 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

LAMP, a new imaging assay of gap junctional communication unveils that Ca²⁺ influx inhibits cell coupling

Dakin, K., Zhao, Y. & Li, W. H., Jan 2005, In: Nature methods. 2, 1, p. 55-62 8 p.

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

2004

Ca²⁺-Dependent Glutamate Release Involves Two Classes of Endoplasmic Reticulum Ca²⁺ Stores in Astrocytes

Hua, X., Malarkey, E. B., Sunjara, V., Rosenwald, S. E., Li, W. H. & Parpura, V., Apr 1 2004, In: Journal of Neuroscience Research. 76, 1, p. 86-97 12 p.

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Critical role of PIP5KIγ87 in InsP₃-mediated Ca ²⁺ signaling

Wang, Y. J., Li, W. H., Wang, J., Xu, K., Dong, P., Luo, X. & Yin, H. L., Dec 20 2004, In: Journal of Cell Biology. 167, 6, p. 1005-1010 6 p.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor

Wagner, L. E., Li, W. H., Joseph, S. K. & Yule, D. I., Oct 29 2004, In: Journal of Biological Chemistry. 279, 44, p. 46242-46252 11 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

New Caged Coumarin Fluorophores with Extraordinary Uncaging Cross Sections Suitable for Biological Imaging Applications

Zhao, Y., Zheng, Q., Dakin, K., Xu, K., Martinez, M. L. & Li, W. H., Apr 14 2004, In: Journal of the American Chemical Society. 126, 14, p. 4653-4663 11 p.

Research output: Contribution to journal › Article › peer-review

215 Scopus citations

2003

Co-incident signalling between μ-opioid and M₃ muscarinic receptors at the level of Ca²⁺ release from intracellular stores: Lack of evidence for Ins(1,4,5)P₃ receptor sensitization

Samways, D. S. K., Li, W. H., Conway, S. J., Holmes, A. B., Bootman, M. D. & Henderson, G., Nov 1 2003, In: Biochemical Journal. 375, 3, p. 713-720 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

ET-1 activates Ca²⁺ sparks in PASMC: Local Ca²⁺ signaling between inositol trisphosphate and ryanodine receptors

Zhang, W. M., Yip, K. P., Lin, M. J., Shimoda, L. A., Li, W. H. & Sham, J. S. K., Sep 1 2003, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 3 29-3, p. L680-L690

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: A mutational analysis of the functionally important sites in the S2⁺ and S2^- splice variants

Wagner, L. E., Li, W. H. & Yule, D. I., Nov 14 2003, In: Journal of Biological Chemistry. 278, 46, p. 45811-45817 7 p.

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

2002

Mechanistic studies of a calcium-dependent MRI contrast agent

Li, W. H., Parigi, G., Fragai, M., Luchinat, C. & Meade, T. J., 2002, In: Inorganic Chemistry. 41, 15, p. 4018-4024 7 p.

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

The role of inositol 1,4,5,-trisphosphate receptors in Ca²⁺ signalling and the generation of arrhythmias in rat atrial myocytes

Mackenzie, L., Bootman, M. D., Laine, M., Berridge, M. J., Thuring, J., Holmes, A., Li, W. H. & Lipp, P., Jun 1 2002, In: Journal of Physiology. 541, 2, p. 395-409 15 p.

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

2000

Cellular regulation of cytosolic group IV phospholipase A₂ by phosphatidylinositol bisphosphate levels

Balsinde, J., Balboa, M. A., Li, W. H., Llopis, J. & Dennis, E. A., May 15 2000, In: Journal of Immunology. 164, 10, p. 5398-5402 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Functional InsP₃ receptors that may modulate excitation-contraction coupling in the heart

Lipp, P., Laine, M., Tovey, S. C., Burrell, K. M., Berridge, M. J., Li, W. & Bootman, M. D., Aug 1 2000, In: Current Biology. 10, 15, p. 939-942 4 p.

Research output: Contribution to journal › Article › peer-review

208 Scopus citations

Inositol 1,4,5-trisphosphate-induced Ca²⁺ release is inhibited by mitochondrial depolarization

Collins, T. J., Lipp, P., Berridge, M. J., Li, W. & Bootman, M. D., Apr 15 2000, In: Biochemical Journal. 347, 2, p. 593-600 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Microscopic properties of elementary Ca²⁺ release sites in non-excitable cells

Thomas, D., Lipp, P., Tovey, S. C., Berridge, M. J., Li, W., Tsien, R. Y. & Bootman, M. D., Jan 1 2000, In: Current Biology. 10, 1, p. 8-15 8 p.

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

1998

2-Deoxy derivative is a partial agonist of the intracellular messenger inositol 3,4,5,6-tetrakisphosphate in the epithelial cell line T₈₄

Rudolf, M. T., Li, W. H., Wolfson, N., Traynor-Kaplan, A. E. & Schultz, C., Sep 10 1998, In: Journal of Medicinal Chemistry. 41, 19, p. 3635-3644 10 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Cell-permeant caged InsP₃ ester shows that Ca²⁺ spike frequency can optimize gene expression

Li, W. H., Llopis, J., Whitney, M., Zlokarnik, G. & Tsien, R. Y., Apr 30 1998, In: Nature. 392, 6679, p. 936-941 6 p.

Research output: Contribution to journal › Article › peer-review

786 Scopus citations

1997

Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications

Li, W., Schultz, C., Llopis, J. & Tsien, R. Y., Sep 1997, In: Tetrahedron. 53, 35, p. 12017-12040 24 p.

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Cell Biology - Division H

Research output

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