PA-Lab Zhang, Qing

2024

FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells

Zhu, Z., Lou, G., Teng, X. L., Wang, H., Luo, Y., Shi, W., Yihunie, K., Hao, S., DeGolier, K., Liao, C., Huang, H., Zhang, Q., Fry, T., Wang, T., Yao, C. & Wu, T., Jan 2024, In: Nature immunology. 25, 1, p. 117-128 12 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

Hu, L., Zhang, Y., Guo, L., Zhong, H., Xie, L., Zhou, J., Liao, C., Yao, H., Fang, J., Liu, H., Zhang, C., Zhang, H., Zhu, X., Luo, M., von Kriegsheim, A., Li, B., Luo, W., Zhang, X., Chen, X., Mendell, J. T., & 5 othersXu, L., Kapur, P., Baldwin, A. S., Brugarolas, J. & Zhang, Q., Feb 15 2024, In: Molecular cell. 84, 4, p. 776-790.e5

Research output: Contribution to journal › Article › peer-review

2023

FDXR drives primary and endocrine-resistant tumor cell growth in ER+ breast cancer via CPT1A-mediated fatty acid oxidation

Yan, C., Gao, R., Gao, C., Hong, K., Cheng, M., Liu, X., Zhang, Q. & Zhang, J., 2023, In: Frontiers in Oncology. 13, 1105117.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Immature natural killer cells promote progression of triple-negative breast cancer

Thacker, G., Henry, S., Nandi, A., Debnath, R., Singh, S., Nayak, A., Susnik, B., Boone, M. M., Zhang, Q., Kesmodel, S. B., Gumber, S., Das, G. M., Kambayashi, T., Dos Santos, C. O. & Chakrabarti, R., Mar 8 2023, In: Science translational medicine. 15, 686, eabl4414.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Optimized protocols for chromatin immunoprecipitation of exogenously expressed epitope-tagged proteins

Fang, W., Liao, C. & Zhang, Q., Mar 17 2023, In: STAR Protocols. 4, 1, 102050.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthesis of the Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitor, 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977, Belzutifan); Efficient Replication of Established Approaches

Hamal, K. B., Pavlich, C. I., Carlson, G. J., Ching Wong, Y., Zhao, F., Zhang, Q., Klausmeyer, K. K. & Pinney, K. G., Sep 19 2023, In: Tetrahedron Letters. 128, 154691.

Research output: Contribution to journal › Article › peer-review

2022

An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

Zhou, J., Simon, J. M., Liao, C., Zhang, C., Hu, L., Zurlo, G., Liu, X., Fan, C., Hepperla, A., Jia, L., Tcheuyap, V. T., Zhong, H., Elias, R., Ye, J., Henne, W. M., Kapur, P., Nijhawan, D., Brugarolas, J. & Zhang, Q., Aug 18 2022, In: Molecular cell. 82, 16, p. 3030-3044.e8

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

Xiao, Y., Ma, D., Yang, Y. S., Yang, F., Ding, J. H., Gong, Y., Jiang, L., Ge, L. P., Wu, S. Y., Yu, Q., Zhang, Q., Bertucci, F., Sun, Q., Hu, X., Li, D. Q., Shao, Z. M. & Jiang, Y. Z., May 2022, In: Cell Research. 32, 5, p. 477-490 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway

Qiu, Z., Guo, W., Dong, B., Wang, Y., Deng, P., Wang, C., Liu, J., Zhang, Q., Grosschedl, R., Yu, Z., Deng, J. & Wu, Y., Jul 12 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 28, e2119518119.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans

Ma, Y., Joyce, A., Brandenburg, O., Saatchi, F., Stevens, C., Toffessi Tcheuyap, V., Christie, A., Do, Q. N., Fatunde, O., Macchiaroli, A., Wong, S. C., Woolford, L., Yousuf, Q., Miyata, J., Carrillo, D., Onabolu, O., McKenzie, T., Mishra, A., Hardy, T., He, W., & 9 othersLi, D., Ivanishev, A., Zhang, Q., Pedrosa, I., Kapur, P., Schluep, T., Kanner, S. B., Hamilton, J. & Brugarolas, J., Dec 15 2022, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 28, 24, p. 5405-5418 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Histone H3 proline 16 hydroxylation regulates mammalian gene expression

Liu, X., Wang, J., Boyer, J. A., Gong, W., Zhao, S., Xie, L., Wu, Q., Zhang, C., Jain, K., Guo, Y., Rodriguez, J., Li, M., Uryu, H., Liao, C., Hu, L., Zhou, J., Shi, X., Tsai, Y. H., Yan, Q., Luo, W., & 7 othersChen, X., Strahl, B. D., von Kriegsheim, A., Zhang, Q., Wang, G. G., Baldwin, A. S. & Zhang, Q., Nov 2022, In: Nature genetics. 54, 11, p. 1721-1735 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Liao, C., Glodowski, C. R., Fan, C., Liu, J., Mott, K. R., Kaushik, A., Vu, H., Locasale, J. W., McBrayer, S. K., DeBerardinis, R. J., Perou, C. M. & Zhang, Q., Feb 15 2022, In: Cancer research. 82, 4, p. 665-680 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Zhang, X., Li, S., He, J., Jin, Y., Zhang, R., Dong, W., Lin, M., Yang, Y., Tian, T., Zhou, Y., Xu, Y., Lei, Q. Y., Zhang, J., Zhang, Q., Xu, Y. & Lv, L., Jun 1 2022, In: Cancer research. 82, 11, p. 2097-2109 13 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer

Xie, H., Zhou, J., Liu, X., Xu, Y., Hepperla, A. J., Simon, J. M., Wang, T., Yao, H., Liao, C., Baldwin, A. S., Gong, K. & Zhang, Q., Sep 6 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, e2119854119.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2021

ZHX2 prom 1 otes hif1α oncogenic signaling in triple-negative breast cancer

Fang, W., Liao, C., Shi, R., Simon, J. M., Ptacek, T. S., Zurlo, G., Ye, Y., Han, L., Fan, C., Ortiz, C. L., Lin, H. R., Manocha, U., Luo, W., Peng, Y., Kim, W. Y., Yang, L. W. & Zhang, Q., Nov 2021, In: eLife. 10, e70412.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2020

Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC

Zurlo, G. & Zhang, Q., Mar 3 2020, In: Molecular and Cellular Oncology. 7, 2, 1707045.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability

Liao, C. & Zhang, Q., Nov 1 2020, In: Molecular and Cellular Oncology. 7, 6, 1813526.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

Liu, X., Simon, J. M., Xie, H., Hu, L., Wang, J., Zurlo, G., Fan, C., Ptacek, T. S., Herring, L., Tan, X., Li, M., Baldwin, A. S., Kim, W. Y., Wu, T., Kirschner, M. W., Gong, K. & Zhang, Q., Mar 19 2020, In: Molecular cell. 77, 6, p. 1294-1306.e5

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Identification of bbox1 as a therapeutic target in triple-negative breast cancer

Liao, C., Zhang, Y., Fan, C., Herring, L. E., Liu, J., Locasale, J. W., Takada, M., Zhou, J., Zurlo, G., Hu, L., Simon, J. M., Ptacek, T. S., Andrianov, V. G., Loza, E., Peng, Y., Yang, H., Perou, C. M. & Zhang, Q., Nov 2020, In: Cancer discovery. 10, 11, p. 1707-1721 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

TBK1 is a synthetic lethal target in cancer with VHL loss

Hu, L., Xie, H., Liu, X., Potjewyd, F., James, L. I., Wilkerson, E. M., Herring, L. E., Xie, L., Chen, X., Cabrera, J. C., Hong, K., Liao, C., Tan, X., Baldwin, A. S., Gong, K. & Zhang, Q., Mar 2020, In: Cancer discovery. 10, 3, p. 460-475 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

USP37 promotes deubiquitination of HIF2α in kidney cancer

Hong, K., Hu, L., Liu, X., Simon, J. M., Ptacek, T. S., Zheng, X., Liao, C., Baldwin, A. S. & Zhang, Q., Jun 9 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 13023-13032 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2019

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth

Cai, W., Su, L., Liao, L., Liu, Z. Z., Langbein, L., Dulaimi, E., Testa, J. R., Uzzo, R. G., Zhong, Z., Jiang, W., Yan, Q., Zhang, Q. & Yang, H., Dec 1 2019, In: Nature communications. 10, 1, 5800.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Zurlo, G., Liu, X., Takada, M., Fan, C., Simon, J. M., Ptacek, T. S., Rodriguez, J., von Kriegsheim, A., Liu, J., Locasale, J. W., Robinson, A., Zhang, J., Holler, J. M., Kim, B., Zikánová, M., Bierau, J., Xie, L., Chen, X., Li, M., Perou, C. M., & 1 othersZhang, Q., Dec 1 2019, In: Nature communications. 10, 1, 5177.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

PA-Lab Zhang, Qing

Research output

Search results