@article{7a1b0d732a364b3ea11cac54d7190e27,
title = "Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC",
abstract = "Hydroxylation is a post-translational modification affecting protein stability, activity or interactome. We identified adenylosuccinate lyase (ADSL) as a novel hydroxylation substrate in triple negative breast cancer. Hydroxylation affects ADSL enzymatic activity and, therefore, adenosine levels. Adenosine, in turn, favors the translation of cMYC, triggering its oncogenic downstream cascade.",
keywords = "ADSL, adenosine, cMYC, hydroxylation, triple negative breast cancer",
author = "Giada Zurlo and Qing Zhang",
note = "Funding Information: This work was supported by the V Foundation Scholar Award, University Cancer Research Fund, Mary Kay Foundation, National Cancer Institute (Q.Z., R01CA211732, R21CA223675), Kimmel Scholar Award, and Susan G. Komen Career Catalyst Award to Q.Z. This work was also supported in part by Cancer Prevention and Research Institute of Texas (CPRIT, RP190058 to Q.Z.). Funding Information: This work was supported by the American Cancer Society (RSG-18-059-01-TBE). This work was supported by the V Foundation Scholar Award, University Cancer Research Fund, Mary Kay Foundation, National Cancer Institute (Q.Z., R01CA211732, R21CA223675), Kimmel Scholar Award, and Susan G. Komen Career Catalyst Award to Q.Z. This work was also supported in part by Cancer Prevention and Research Institute of Texas (CPRIT, RP190058 to Q.Z.). Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Taylor & Francis Group, LLC.",
year = "2020",
month = mar,
day = "3",
doi = "10.1080/23723556.2019.1707045",
language = "English (US)",
volume = "7",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "2",
}