Int Med - Touchstone Diab Ctr

Research output

Research output per year 1955 1978 1979 2003 2004 2005 2006 2007 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2024

• 1009 Article
• 130 Review article
• 39 Comment/debate
• 25 Short survey
• 48 More
  • 22 Letter
  • 13 Chapter
  • 13 Editorial

Research output per year

Research output per year

Search results

• 2018

  Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

  Roh, H. C., Tsai, L. T. Y., Shao, M., Tenen, D., Shen, Y., Kumari, M., Lyubetskaya, A., Jacobs, C., Dawes, B., Gupta, R. K. & Rosen, E. D., May 1 2018, In: Cell Metabolism. 27, 5, p. 1121-1137.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Beige Adipocytes 100%
  • Brown Adipocytes 88%
  • Epigenomics 43%
  • Cold Temperature 33%
  • Temperature 26%
  155 Scopus citations
• 2017

  Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression

  Rutkowski, J. M., Pastor, J., Sun, K., Park, S. K., Bobulescu, I. A., Chen, C. T., Moe, O. W. & Scherer, P. E., Feb 1 2017, In: Kidney international. 91, 2, p. 324-337 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • calcium phosphate 100%
  • Adiponectin 98%
  • Kidney 48%
  • fibroblast growth factor 23 31%
  • Minerals 22%
  42 Scopus citations

• Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target

  Marangoni, R. G., Masui, Y., Fang, F., Korman, B., Lord, G., Lee, J., Lakota, K., Wei, J., Scherer, P. E., Otvos, L., Yamauchi, T., Kubota, N., Kadowaki, T., Asano, Y., Sato, S., Tourtellotte, W. G. & Varga, J., Dec 1 2017, In: Scientific reports. 7, 1, 4397.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adiponectin 100%
  • Systemic Scleroderma 58%
  • Skin 51%
  • Fibrosis 38%
  • Mouse Adipoq protein 35%
  62 Scopus citations

• Adiponectin protects against incident hypertension independent of body fat distribution: observations from the Dallas Heart Study

  Peri-Okonny, P. A., Ayers, C., Maalouf, N. M., Das, S. R., de Lemos, J. A., Berry, J. D., Turer, A. T., Neeland, I. J., Scherer, P. E. & Vongpatanasin, W., Feb 1 2017, In: Diabetes/Metabolism Research and Reviews. 33, 2, e2840.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Body Fat Distribution 100%
  • Adiponectin 80%
  • Intra-Abdominal Fat 50%
  • Hypertension 48%
  • Heart 48%
  27 Scopus citations

• Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors

  Zhang, D., Wang, X., Wang, B., Garza, J. C., Fang, X., Wang, J., Scherer, P. E., Brenner, R., Zhang, W. & Lu, X. Y., Jul 1 2017, In: Molecular psychiatry. 22, 7, p. 1044-1055 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psychological Extinction 100%
  • Dentate Gyrus 94%
  • Adiponectin 93%
  • Fear 75%
  • Neurons 53%
  79 Scopus citations

• Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis

  Jun, J. C., Devera, R., Unnikrishnan, D., Shin, M. K., Bevans-Fonti, S., Yao, Q., Rathore, A., Younas, H., Halberg, N., Scherer, P. E. & Polotsky, V. Y., Mar 1 2017, In: Journal of Molecular Medicine. 95, 3, p. 287-297 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypoxia-Inducible Factor 1 100%
  • Thermogenesis 97%
  • Brown Adipose Tissue 96%
  • Brown 82%
  • Weight Gain 66%
  34 Scopus citations

• Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

  Ying, W., Wollam, J., Ofrecio, J. M., Bandyopadhyay, G., El Ouarrat, D., Lee, Y. S., Oh, D., Li, P., Osborn, O. & Olefsky, J. M., Mar 1 2017, In: Journal of Clinical Investigation. 127, 3, p. 1019-1030 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukotriene B4 100%
  • Leukotrienes 98%
  • Adipose Tissue 67%
  • Insulin Resistance 66%
  • Leukotriene B4 Receptors 16%
  96 Scopus citations

• Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

  Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In: Cell Metabolism. 25, 6, p. 1348-1361.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon Receptors 100%
  • Amino Acid Transport Systems 87%
  • Glucagon 66%
  • Hyperplasia 56%
  • Amino Acids 22%
  129 Scopus citations

• An adipo-biliary-uridine axis that regulates energy homeostasis

  Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In: Science. 355, 6330, eaaf5375.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Uridine 100%
  • Homeostasis 60%
  • Body Temperature Regulation 23%
  • Fasting 21%
  • Leptin 18%
  83 Scopus citations

• Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

  An, Y. A., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M. & Scherer, P. E., Mar 29 2017, In: eLife. 6, e24071.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Angiopoietin-2 100%
  • White Adipose Tissue 85%
  • White 59%
  • Metabolic 57%
  • Homeostasis 51%
  56 Scopus citations

• Cutting edge: Targeting epithelial ORMDL3 increases, rather than reduces, airway responsiveness and is associated with increased sphingosine-1-phosphate

  Miller, M., Tam, A. B., Mueller, J. L., Rosenthal, P., Beppu, A., Gordillo, R., McGeough, M. D., Vuong, C., Doherty, T. A., Hoffman, H. M., Niwa, M. & Broide, D. H., Apr 15 2017, In: Journal of Immunology. 198, 8, p. 3017-3022 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sphingosine 1-phosphate 100%
  • Allergens 24%
  • Epithelium 19%
  • Inflammation 15%
  • Mucus 13%
  44 Scopus citations

• Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK–LKB1 signaling axis

  Casimiro, M. C., Di Sante, G., Di Rocco, A., Loro, E., Pupo, C., Pestell, T. G., Bisetto, S., Velasco-Velázquez, M. A., Jiao, X., Li, Z., Kusminski, C. M., Seifert, E. L., Wang, C., Ly, D., Zheng, B., Shen, C. H., Scherer, P. E. & Pestell, R. G., Jul 1 2017, In: Cancer research. 77, 13, p. 3391-3405 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclin D1 100%
  • Autophagy 88%
  • Oncogenes 87%
  • Cyclins 55%
  • AMP-activated protein kinase kinase 34%
  45 Scopus citations

• Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

  Wang, M-Y., Yu, X., Lee, Y. H., McCorkle, S. K., Chen, S., Li, J., Wang, Z., Davidson, J. A., Scherer, P. E., Holland, W. L., Unger, R. H. & Roth, M. G., Jun 20 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6611-6616 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol 100%
  • Glucagon 67%
  • Rodentia 53%
  • Sodium-Glucose Transport Proteins 45%
  • Glucose 33%
  25 Scopus citations

• Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

  Hepler, C., Shao, M., Xia, J. Y., Ghaben, A. L., Pearson, M. J., Vishvanath, L., Sharma, A. X., Morley, T. S., Holland, W. L. & Gupta, R. K., Jul 19 2017, In: eLife. 6, e27669.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thermogenic 100%
  • White Adipocytes 85%
  • Obese Mice 69%
  • White Adipose Tissue 69%
  • Insulin Derivative 58%
  33 Scopus citations

• Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice

  Onodera, T., Fukuhara, A., Shin, J., Hayakawa, T., Otsuki, M. & Shimomura, I., Dec 1 2017, In: Scientific reports. 7, 1, 4560.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-hydroxy-6,8,11,14,17-eicosapentaenoic acid 100%
  • Eicosapentaenoic Acid 57%
  • Macrophages 32%
  • Adipose Tissue 17%
  • Diet 4%
  43 Scopus citations

• Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

  Lu, Z., Xie, J., Wu, G., Shen, J., Collins, R. H., Chen, W., Kang, X., Luo, M., Zou, Y., Huang, J-S., Amatruda, J. F., Slone, T. L., Winick, N. J., Scherer, P. E. & Zhang, C., Jan 1 2017, In: Nature medicine. 23, 1, p. 79-90 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leptin Receptors 100%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 75%
  • Fasting 61%
  • Up-Regulation 55%
  • Block Like Crystal 51%
  91 Scopus citations

• Fetal development of subcutaneous white adipose tissue is dependent on Zfp423

  Shao, M., Hepler, C., Vishvanath, L., MacPherson, K. A., Busbuso, N. C. & Gupta, R. K., Jan 1 2017, In: Molecular Metabolism. 6, 1, p. 111-124 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • White Adipose Tissue 100%
  • Subcutaneous Fat 92%
  • Fetal Development 84%
  • White Adipocytes 73%
  • Adiponectin 70%
  43 Scopus citations

• FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

  Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J., Nov 7 2017, In: Cell Metabolism. 26, 5, p. 709-718.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fibroblast growth factor 21 100%
  • Nervous System 55%
  • Body Weight 48%
  • Antibodies 38%
  • Weight Loss 37%
  180 Scopus citations

• General theory of skin reinforcement

  Kruglikov, I. L. & Scherer, P. E., Aug 2017, In: PloS one. 12, 8, e0182865.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • White Adipose Tissue 100%
  • white adipose tissue 92%
  • Subcutaneous Fat 92%
  • White 80%
  • skin (animal) 73%
  19 Scopus citations

• Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses

  Wende, A. R., Kim, J., Holland, W. L., Wayment, B. E., O’Neill, B. T., Tuinei, J., Brahma, M. K., Pepin, M. E., McCrory, M. A., Luptak, I., Halade, G. V., Litwin, S. E. & Abel, E. D., Dec 2017, In: American Journal of Physiology - Heart and Circulatory Physiology. 313, 6, p. H1098-H1108

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Physiological Stress 100%
  • Facilitative Glucose Transport Proteins 97%
  • Hypertrophy 76%
  • Heart 54%
  • Ceramides 24%
  41 Scopus citations

• Hepatic gale regulates whole-body glucose homeostasis by modulating tff3 expression

  Zhu, Y., Zhao, S., Deng, Y., Gordillo, R., Ghaben, A. L., Shao, M., Zhang, F., Xu, P., Li, Y., Cao, H., Zagnitko, O., Scott, D. A., Gupta, R. K., Xing, C., Zhang, B. B., Lin, H. V. & Scherer, P. E., 2017, In: Diabetes. 66, 11, p. 2789-2799 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Trefoil Factor-3 100%
  • Homeostasis 89%
  • galactose epimerase 77%
  • Glucose 77%
  • Liver 63%
  18 Scopus citations

• High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner

  Taylor, O. J., Thatcher, M. O., Carr, S. T., Gibbs, J. L., Trumbull, A. M., Harrison, M. E., Winden, D. R., Pearson, M. J., Tippetts, T. S., Holland, W. L., Reynolds, P. R. & Bikman, B. T., May 20 2017, In: International journal of molecular sciences. 18, 5, 1099.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ceramides 100%
  • smoke 61%
  • Ceramide 58%
  • Smoke 55%
  • Myriocin 53%
  9 Scopus citations

• Hypoglycemic effect of combined ghrelin and glucagon receptor blockade

  Mani, B. K., Uchida, A., Lee, Y. H., Osborne-Lawrence, S., Charron, M. J., Unger, R. H., Berglund, E. D. & Zigman, J. M., Jul 1 2017, In: Diabetes. 66, 7, p. 1847-1857 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon Receptors 100%
  • Ghrelin Receptor 91%
  • Ghrelin 76%
  • Hypoglycemic Agents 61%
  • Blood Glucose 26%
  26 Scopus citations

• Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

  Holland, W. L., Xia, J. Y., Johnson, J. A., Sun, K., Pearson, M. J., Sharma, A. X., Quittner-Strom, E., Tippetts, T. S., Gordillo, R. & Scherer, P. E., Mar 1 2017, In: Molecular Metabolism. 6, 3, p. 267-275 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ceramidases 100%
  • Adiponectin Receptors 88%
  • Adiponectin 63%
  • Homeostasis 43%
  • Lipids 38%
  130 Scopus citations

• Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells

  Mugabo, Y., Zhao, S., Lamontagne, J., Al-Mass, A., Peyot, M. L., Corkey, B. E., Joly, E., Madiraju, S. R. M. & Prentki, M., May 5 2017, In: Journal of Biological Chemistry. 292, 18, p. 7407-7422 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Detoxification 100%
  • Metabolic 73%
  • Glucose 66%
  • Insulin Derivative 38%
  • Insulin Secretion 37%
  43 Scopus citations

• MicroRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

  Hajarnis, S., Lakhia, R., Yheskel, M., Williams, D., Sorourian, M., Liu, X., Aboudehen, K., Zhang, S., Kersjes, K., Galasso, R., Li, J., Kaimal, V., Lockton, S., Davis, S., Flaten, A., Johnson, J. A., Holland, W. L., Kusminski, C. M., Scherer, P. E., Harris, P. C., & 6 othersTrudel, M., Wallace, D. P., Igarashi, P., Lee, E. C., Androsavich, J. R. & Patel, V., Feb 16 2017, In: Nature communications. 8, 14395.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • kidney diseases 100%
  • Autosomal Dominant Polycystic Kidney 67%
  • Polycystic Kidney Diseases 67%
  • cysts 64%
  • metabolism 64%
  139 Scopus citations

• MitoNEET-dependent formation of intermitochondrial junctions

  Vernay, A., Marchetti, A., Sabra, A., Jauslin, T. N., Rosselin, M., Scherer, P. E., Demaurex, N., Orci, L. & Cosson, P., Aug 1 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8277-8282 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial Size 100%
  • Mitochondria 57%
  • Cell Respiration 48%
  • Cluster Analysis 30%
  • Membrane Proteins 28%
  41 Scopus citations

• Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide

  Miller, M., Rosenthal, P., Beppu, A., Gordillo, R. & Broide, D. H., Apr 1 2017, In: Journal of Allergy and Clinical Immunology. 139, 4, p. 1373-1376.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  33 Scopus citations

• PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

  Luo, X., Ryu, K. W., Kim, D. S., Nandu, T., Medina, C. J., Gupte, R., Gibson, B. A., Soccio, R. E., Yu, Y., Gupta, R. K. & Kraus, W. L., Jan 19 2017, In: Molecular cell. 65, 2, p. 260-271 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly ADP Ribosylation 100%
  • Adipogenesis 11%
  • Post Translational Protein Processing 9%
  • Transcription Factors 7%
  • Amino Acids 6%
  82 Scopus citations

• Regeneration of fat cells from myofibroblasts during wound healing

  Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T. C., Oh, J. W., Wang, X., Ramirez, A., Konopelski, S. E., Elzein, A., Wang, A., Supapannachart, R. J., Lee, H. L., Lim, C. H., Nace, A., & 18 othersGuo, A., Treffeisen, E., Andl, T., Ramirez, R. N., Murad, R., Offermanns, S., Metzger, D., Chambon, P., Widgerow, A. D., Tuan, T. L., Mortazavi, A., Gupta, R. K., Hamilton, B. A., Millar, S. E., Seale, P., Pear, W. S., Lazar, M. A. & Cotsarelis, G., Feb 17 2017, In: Science. 355, 6326, p. 748-752 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myofibroblasts 100%
  • Adipocytes 82%
  • Bone Morphogenetic Proteins 79%
  • Wound Healing 76%
  • Hair Follicle 75%
  380 Scopus citations

• Regulation of Dipeptidyl Peptidase-4, its Substrate Chemokines, and Their Receptors in Adipose Tissue of ob/ob Mice

  Shin, J., Fukuhara, A., Onodera, T., Yokoyama, C., Otsuki, M. & Shimomura, I., May 1 2017, In: Hormone and Metabolic Research. 49, 5, p. 380-387 8 p., hmr2016-06-0189.

  Research output: Contribution to journal › Article › peer-review

  • Dipeptidyl Peptidase 4 100%
  • White Adipose Tissue 90%
  • Chemokine Receptors 83%
  • White 62%
  • Adipose Tissue 61%
  9 Scopus citations

• Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations

  Nitschké, M., Bell, A., Karaman, S., Amouzgar, M., Rutkowski, J. M., Scherer, P. E., Alitalo, K. & McDonald, D. M., Sep 2017, In: American Journal of Pathology. 187, 9, p. 1984-1997 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chylothorax 100%
  • Lymph 79%
  • Chyle 74%
  • Transgenic Mice 64%
  • Thoracic Cavity 48%
  18 Scopus citations

• Short-term versus long-term effects of adipocyte toll-like receptor 4 activation on insulin resistance in male mice

  Tao, C., Holland, W. L., Wang, Q. A., Shao, M., Jia, L., Sun, K., Lin, X., Kuo, Y. C., Johnson, J. A., Gordillo, R., Elmquist, J. K. & Scherer, P. E., May 1 2017, In: Endocrinology. 158, 5, p. 1260-1270 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toll-Like Receptor 4 100%
  • Adipocytes 82%
  • Insulin Resistance 71%
  • Adipose Tissue 19%
  • High Fat Diet 15%
  29 Scopus citations

• The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment

  Hepler, C. & Gupta, R. K., Apr 15 2017, In: Molecular and Cellular Endocrinology. 445, p. 95-108 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Beige 100%
  • Brown 61%
  • Adipocytes 56%
  • White 49%
  • Adipose Tissue 49%
  59 Scopus citations

• VEGF-A - Expressing adipose tissue shows rapid beiging and enhanced survival after transplantation and confers IL-4-independent metabolic improvements

  Park, J., Kim, M., Sun, K., An, Y. A., Gu, X. & Scherer, P. E., Jun 1 2017, In: Diabetes. 66, 6, p. 1479-1490 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-4 100%
  • Vascular Endothelial Growth Factor A 92%
  • Adipose Tissue 89%
  • Transplantation 82%
  • Adipocytes 61%
  81 Scopus citations
• 2016

  Adipocyte-specific deletion of manganese superoxide dismutase protects from diet-induced obesity through increased mitochondrial uncoupling and biogenesis

  Han, Y. H., Buffolo, M., Pires, K. M., Pei, S., Scherer, P. E. & Boudina, S., Sep 1 2016, In: Diabetes. 65, 9, p. 2639-2651 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organelle Biogenesis 100%
  • Adipocytes 74%
  • Superoxide Dismutase 72%
  • Knockout Mice 72%
  • High Fat Diet 65%
  69 Scopus citations

• Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

  Sun, J., Gao, Y., Yao, T., Huang, Y., He, Z., Kong, X., Yu, K. J., Wang, R. T., Guo, H., Yan, J., Chang, Y., Chen, H., Scherer, P. E., Liu, T. & Williams, K. W., Oct 1 2016, In: Molecular Metabolism. 5, 10, p. 882-891 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pro-Opiomelanocortin 100%
  • Adiponectin 83%
  • Leptin 77%
  • Melanocortins 49%
  • Neurons 47%
  51 Scopus citations

• A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism

  Amoasii, L., Holland, W., Sanchez-Ortiz, E., Baskin, K. K., Pearson, M., Burgess, S. C., Nelson, B. R., Bassel-Duby, R. & Olson, E. N., Feb 15 2016, In: Genes and Development. 30, 4, p. 434-446 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Skeletal Muscle 100%
  • Homeostasis 92%
  • Glucose 79%
  • Liver 64%
  • Mediator Complex 55%
  30 Scopus citations

• An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production

  Evans, M. R., Wei, S., Posner, B. A., Unger, R. H. & Roth, M. G., Apr 1 2016, In: Journal of Biomolecular Screening. 21, 4, p. 325-332 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon 100%
  • Insulin Derivative 18%
  • Glucagon Receptors 16%
  • Insulin 14%
  • Glucose 13%
  9 Scopus citations

• A role of the inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents

  Kursawe, R., Dixit, V. D., Scherer, P. E., Santoro, N., Narayan, D., Gordillo, R., Giannini, C., Lopez, X., Pierpont, B., Nouws, J., Shulman, G. I. & Caprio, S., Mar 2016, In: Diabetes. 65, 3, p. 610-618 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Abdominal Subcutaneous Fat 100%
  • Inflammasomes 84%
  • Subcutaneous Fat 78%
  • Intra-Abdominal Fat 78%
  • Lipogenesis 21%
  80 Scopus citations

• Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges

  Ye, R., Wang, M., Wang, Q. A., Spurgin, S. B., Wang, Z. V., Sun, K. & Scherer, P. E., Jul 1 2016, In: Molecular Metabolism. 5, 7, p. 437-448 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Regeneration 100%
  • Tamoxifen 63%
  • Pharmacology 39%
  • Genetic Engineering 37%
  • Apoptosis 36%
  16 Scopus citations

• Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

  Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., Gupta, O., Holland, W. L., Gupta, R. K., Spray, D. C., Tanowitz, H. B., Cao, L., Lynes, M. D., Tseng, Y. H., Elmquist, J. K., Williams, K. W., & 2 othersLin, H. V. & Scherer, P. E., Sep 13 2016, In: Cell Metabolism. 24, 3, p. 420-433 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Connexin 43 100%
  • White Adipose Tissue 99%
  • Beige Adipocytes 79%
  • Cold Temperature 43%
  • Pro-Opiomelanocortin 42%
  76 Scopus citations

• Dermal adipocytes and hair cycling: Is spatial heterogeneity a characteristic feature of the dermal adipose tissue depot?

  Kruglikov, I. L. & Scherer, P. E., Apr 1 2016, In: Experimental Dermatology. 25, 4, p. 258-262 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hair 100%
  • Adipocytes 96%
  • Heterogeneity 93%
  • White Adipose Tissue 92%
  • White 84%
  46 Scopus citations

• Elevated adiponectin prevents HIV protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice

  Dasuri, K., Pepping, J. K., Fernandez-Kim, S. OK., Gupta, S., Keller, J. N., Scherer, P. E. & Bruce-Keller, A. J., Jun 1 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 6, p. 1228-1235 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mouse Adipoq protein 100%
  • HIV Protease Inhibitors 83%
  • Adiponectin 62%
  • Lopinavir 61%
  • Ritonavir 54%
  4 Scopus citations

• Heart Failure with Preserved Ejection Fraction Induces Beiging in Adipose Tissue

  Valero-Munõz, M., Li, S., Wilson, R. M., Hulsmans, M., Aprahamian, T., Fuster, J. J., Nahrendorf, M., Scherer, P. E. & Sam, F., Jan 1 2016, In: Circulation: Heart Failure. 9, 1

  Research output: Contribution to journal › Article › peer-review

  • Adipose Tissue 100%
  • Heart Failure 87%
  • White Adipose Tissue 48%
  • Brown Adipose Tissue 36%
  • Uncoupling Protein 1 28%
  54 Scopus citations

• Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

  Li, P., Liu, S., Lu, M., Bandyopadhyay, G., Oh, D., Imamura, T., Johnson, A. M. F., Sears, D., Shen, Z., Cui, B., Kong, L., Hou, S., Liang, X., Iovino, S., Watkins, S. M., Ying, W., Osborn, O., Wollam, J., Brenner, M. & Olefsky, J. M., Nov 3 2016, In: Cell. 167, 4, p. 973-984.e12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Galectin 3 100%
  • Insulin Derivative 77%
  • Insulin Resistance 62%
  • Resistance 47%
  • Obese Mice 23%
  207 Scopus citations

• Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis

  Ding, Y., Xian, X., Holland, W. L., Tsai, S. & Herz, J., May 1 2016, In: EBioMedicine. 7, p. 135-145 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Low Density Lipoprotein Receptor-Related Protein-1 100%
  • Insulin Derivative 69%
  • Lipoprotein Receptors 65%
  • Insulin Resistance 56%
  • Lipoprotein 43%
  53 Scopus citations

• Metabolic endotoxaemia in childhood obesity

  Varma, M. C., Kusminski, C. M., Azharian, S., Gilardini, L., Kumar, S., Invitti, C. & McTernan, P. G., 2016, In: BMC Obesity. 3, 1, 3.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endotoxemia 100%
  • Pediatric Obesity 88%
  • Endotoxins 82%
  • childhood 56%
  • Biomarkers 30%
  22 Scopus citations

• MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

  Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In: Diabetes. 65, 6, p. 1534-1555 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Survival 100%
  • Insulin Secretion 26%
  • Hyperglycemia 23%
  • Glucose 16%
  • Mitochondrial Proteins 14%
  54 Scopus citations

• Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

  Gallardo-Montejano, V. I., Saxena, G., Kusminski, C. M., Yang, C., McAfee, J. L., Hahner, L., Hoch, K., Dubinsky, W., Narkar, V. A. & Bickel, P. E., Aug 24 2016, In: Nature communications. 7, 12723.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Perilipin-5 100%
  • catecholamine 85%
  • Lipid Droplets 61%
  • Lipolysis 60%
  • lipids 50%
  102 Scopus citations