Immunology - Farrar Lab – Research output — University of Texas Southwestern Medical Center

Davis, K. E., Killeen, A. L., Farrar, D., Raspovic, K. M., Berriman-Rozen, Z. D., Malone, M. & Lavery, L. A., Dec 2020, In: International Wound Journal. 17, 6, p. 1893-1901 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Randomized clinical study to compare negative pressure wound therapy with simultaneous saline irrigation and traditional negative pressure wound therapy for complex foot infections

Davis, K. E., La Fontaine, J., Farrar, D., Oz, O. K., Crisologo, P. A., Berriman, S. & Lavery, L. A., Jan 1 2020, In: Wound Repair and Regeneration. 28, 1, p. 97-104 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers

Lavery, L. A., Killeen, A. L., Farrar, D., Akgul, Y., Crisologo, P. A., Malone, M. & Davis, K. E., Dec 2020, In: International Wound Journal. 17, 6, p. 1986-1995 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

The infected diabetic foot: Can serum biomarkers predict osteomyelitis after hospital discharge for diabetic foot infections?

Crisologo, P. A., Davis, K. E., Ahn, J., Farrar, D., Van Asten, S., La Fontaine, J. & Lavery, L. A., Sep 1 2020, In: Wound Repair and Regeneration. 28, 5, p. 617-622 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2018

Adrenergic signaling at the interface of allergic asthma and viral infections

Agaç, D., Gill, M. A. & Farrar, J. D., Apr 11 2018, In: Frontiers in immunology. 9, APR, 736.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V. & Farrar, J. D., Nov 2018, In: Brain, Behavior, and Immunity. 74, p. 176-185 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

2016

Cutting Edge: Critical role of glycolysis in human plasmacytoid dendritic cell antiviral responses

Bajwa, G., DeBerardinis, R. J., Shao, B., Hall, B., Farrar, J. D. & Gill, M. A., Mar 1 2016, In: Journal of Immunology. 196, 5, p. 2004-2009 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells

Gonzales-van Horn, S. R., Estrada, L. D., van Oers, N. S. C. & Farrar, J. D., Jun 1 2016, In: European Journal of Immunology. 46, 6, p. 1504-1510 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8⁺ T-cell effector function

Estrada, L. D., Ağaç, D. & Farrar, J. D., Aug 1 2016, In: European Journal of Immunology. 46, 8, p. 1948-1958 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

2015

Housing temperature-induced stress is suppressing murine Graft-versus-host disease through β2-adrenergic receptor signaling

Leigh, N. D., Kokolus, K. M., O'Neill, R. E., Du, W., Eng, J. W. L., Qiu, J., Chen, G. L., McCarthy, P. L., Farrar, J. D., Cao, X. & Repasky, E. A., Nov 15 2015, In: Journal of Immunology. 195, 10, p. 5045-5054 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2014

IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells

Huber, J. P., Gonzales-Van Horn, S. R., Roybal, K. T., Gill, M. A. & Farrar, J. D., Jun 15 2014, In: Journal of Immunology. 192, 12, p. 5687-5694 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions

Chowdhury, F. Z., Estrada, L. D., Murray, S., Forman, J. & Farrar, J. D., Mar 18 2014, In: PloS one. 9, 3, e92187.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2013

IgE cross-linking critically impairs human monocyte function by blocking phagocytosis

Pyle, D. M., Yang, V. S., Gruchalla, R. S., Farrar, J. D. & Gill, M. A., Feb 2013, In: Journal of Allergy and Clinical Immunology. 131, 2, p. 491-500.e5

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

Becker, A. M., Dao, K. H., Han, B. K., Kornu, R., Lakhanpal, S., Mobley, A. B., Li, Q. Z., Lian, Y., Wu, T., Reimold, A. M., Olsen, N. J., Karp, D. R., Chowdhury, F. Z., Farrar, J. D., Satterthwaite, A. B., Mohan, C., Lipsky, P. E., Wakeland, E. K. & Davis, L. S., Jun 24 2013, In: PloS one. 8, 6, e67003.

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

2011

IL-12 selectively programs effector pathways that are stably expressed in human CD8⁺ effector memory T cells in vivo

Chowdhury, F. Z., Ramos, H. J., Davis, L. S., Forman, J. & Farrar, J. D., Oct 6 2011, In: Blood. 118, 14, p. 3890-3900 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2010

Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

Huber, J. P., Ramos, H. J., Gill, M. A. & Farrar, J. D., Jul 15 2010, In: Journal of Immunology. 185, 2, p. 813-817 5 p.

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

2009

Reciprocal responsiveness to interleukin-12 and interferon-α specifies human CD8⁺ effector versus central memory T-cell fates

Ramos, H. J., Davis, A. M., Cole, A. G., Schatzle, J. D., Forman, J. & Farrar, J. D., 2009, In: Blood. 113, 22, p. 5516-5525 10 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

2008

Blockade of virus infection by human CD4⁺ T cells via a cytokine relay network

Davis, A. M., Hagan, K. A., Matthews, L. A., Bajwa, G., Gill, M. A., Gale, M. & Farrar, J. D., 2008, In: Journal of Immunology. 180, 10, p. 6923-6932 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Cutting edge: A T-bet-independent role for IFN-α/β in regulating IL-2 secretion in human CD4⁺ central memory T cells

Davis, A. M., Ramos, H. J., Davis, L. S. & David Farrar, J., Dec 15 2008, In: Journal of Immunology. 181, 12, p. 8204-8208 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

Young, J. A., Becker, A. M., Medeiros, J. J., Shapiro, V. S., Wang, A., Farrar, J. D., Quill, T. A., van Huijsduijnen, R. H. & van Oers, N. S. C., Aug 2008, In: Molecular Immunology. 45, 14, p. 3756-3766 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2007

IFN-α is not sufficient to drive Th1 development due to lack of stable T-bet expression

Ramos, H. J., Davis, A. M., George, T. C. & Farrar, J. D., Sep 15 2007, In: Journal of Immunology. 179, 6, p. 3792-3803 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Pre-assembly of STAT4 with the human IFN-α/β receptor-2 subunit is mediated by the STAT4 N-domain

Tyler, D. R., Persky, M. E., Matthews, L. A., Chan, S. & Farrar, J. D., Mar 2007, In: Molecular Immunology. 44, 8, p. 1864-1872 9 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2006

Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-α

Berenson, L. S., Gavrieli, M., Farrar, J. D., Murphy, T. L. & Murphy, K. M., Oct 15 2006, In: Journal of Immunology. 177, 8, p. 5195-5203 9 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

2005

IL-12, but not IFN-α, promotes STAT4 activation and Th1 development in murine CD4⁺ T cells expressing a chimeric murine/human Stat2 gene

Persky, M. E., Murphy, K. M. & Farrar, J. D., Jan 1 2005, In: Journal of Immunology. 174, 1, p. 294-301 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2004

Frontline: Absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-α

Berenson, L. S., Farrar, J. D., Murphy, T. L. & Murphy, K. M., Sep 2004, In: European Journal of Immunology. 34, 9, p. 2365-2374 10 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2001

An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3

David Farrar, J., Ouyang, W., Löhning, M., Assenmacher, M., Radbruch, A., Kanagawa, O. & Murphy, K. M., Mar 5 2001, In: Journal of Experimental Medicine. 193, 5, p. 643-649 7 p.

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

2000

Recruitment of Stat4 to the human interferon-α/β receptor requires activated Stat2

Farrar, J. D., Smith, J. D., Murphy, T. L. & Murphy, K. M., Jan 28 2000, In: Journal of Biological Chemistry. 275, 4, p. 2693-2697 5 p.

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation

Murphy, T. L., Geissal, E. D., Farrar, J. D. & Murphy, K. M., 2000, In: Molecular and cellular biology. 20, 19, p. 7121-7131 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

Farrar, J. D., Smith, J. D., Murphy, T. L., Leung, S., Stark, G. R. & Murphy, K. M., Jul 2000, In: Nature immunology. 1, 1, p. 65-69 5 p.

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

1999

Cancer dormancy. VII. A regulatory role for CD8⁺ T cells and IFN-γ in establishing and maintaining the tumor-dormant state

Farrar, J. D., Katz, K. H., Windsor, J., Thrush, G., Scheuermann, R. H., Uhr, J. W. & Street, N. E., Mar 1 1999, In: Journal of Immunology. 162, 5, p. 2842-2849 8 p.

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

1996

Regulation of tumor dormancy by cd4⁺ and cd8⁺ t cell subpopulations

David Farrar, J., Katz, K. S., Windsor, J. L., Jonathan, W. & Street, U. N. E., 1996, In: FASEB Journal. 10, 6, p. A1444

Research output: Contribution to journal › Article › peer-review

1995

A synthetic standard DNA construct for use in quantification of murine cytokine mRNA molecules

David Farrar, J. & Street, N. E., Sep 1995, In: Molecular Immunology. 32, 13, p. 991-1000 10 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

1993

Defective mannosylation of glycosylphosphatidylinositol in Lec35 Chinese hamster ovary cells

Camp, L. A., Chauhan, P., Farrar, J. D. & Lehrman, M. A., Mar 25 1993, In: Journal of Biological Chemistry. 268, 9, p. 6721-6728 8 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

1992

Differential temporal and spatial expression of mRNA encoding extracellular matrix components in decidua during the peri-implantation period

Farrar, J. D. & Carson, D. D., 1992, In: Biology of reproduction. 46, 6, p. 1095-1108 14 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

1990

Selective activation of the N-glycosylation apparatus in uteri by estrogen

Carson, D. D., David Farrar, J., Laidlaw, J. & Wright, D. A., 1990, In: Journal of Biological Chemistry. 265, 5, p. 2947-2955 9 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Immunology - Farrar Lab

Research output

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