Cell Biology - Division T – Research output — University of Texas Southwestern Medical Center

2018

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

Feng, J., Dong, X., Pinello, J., Zhang, J., Lu, C., Iacob, R. E., Engen, J. R., Snell, W. J. & Springer, T. A., Oct 2018, In: eLife. 7, e39772.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2017

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

Angrisano, F., Sala, K. A., Da, D. F., Liu, Y., Pei, J., Grishin, N. V., Snell, W. J. & Blagborough, A. M., Dec 5 2017, In: Cell Reports. 21, 10, p. 2868-2878 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein

Fédry, J., Liu, Y., Péhau-Arnaudet, G., Pei, J., Li, W., Tortorici, M. A., Traincard, F., Meola, A., Bricogne, G., Grishin, N. V., Snell, W. J., Rey, F. A. & Krey, T., Feb 23 2017, In: Cell. 168, 5, p. 904-915.e10

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

2016

Endogenous B-ring oxysterols inhibit the hedgehog component smoothened in a manner distinct from cyclopamine or side-chain oxysterols

Sever, N., Mann, R. K., Xu, L., Snell, W. J., Hernandez-Lara, C. I., Porter, N. A. & Beachy, P. A., May 24 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 5904-5909 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2015

Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

Haubrich, B. A., Collins, E. K., Howard, A. L., Wang, Q., Snell, W. J., Miller, M. B., Thomas, C. D., Pleasant, S. K. & Nes, W. D., May 17 2015, In: Phytochemistry. 113, p. 64-72 9 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

The cytoplasmic domain of the gamete membrane fusion protein HAP2 targets the protein to the fusion site in Chlamydomonas and regulates the fusion reaction

Liu, Y., Pei, J., Grishin, N. & Snell, W. J., 2015, In: Development (Cambridge). 142, 5, p. 962-971 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

Cao, M., Ning, J., Hernandez-Lara, C. I., Belzile, O., Wang, Q., Dutcher, S. K., Liu, Y. & Snell, W. J., Feb 17 2015, In: eLife. 2015, 4, e05242.

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

2013

Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length

Cao, M., Meng, D., Wang, L., Bei, S., Snell, W. J. & Pan, J., Jul 23 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12337-12342 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates

Ning, J., Otto, T. D., Pfander, C., Schwach, F., Brochet, M., Bushell, E., Goulding, D., Sanders, M., Lefebvre, P. A., Pei, J., Grishin, N. V., Vanderlaan, G., Billker, O. & Snell, W. J., May 15 2013, In: Genes and Development. 27, 10, p. 1198-1215 18 p.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Regulated membrane protein entry into flagella is facilitated by cytoplasmic microtubules and does not require IFT

Belzile, O., Hernandez-Lara, C. I., Wang, Q. & Snell, W. J., Aug 5 2013, In: Current Biology. 23, 15, p. 1460-1465 6 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

2012

Evolutionarily conserved Δ²⁵⁽²⁷⁾-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii

Miller, M. B., Haubrich, B. A., Wang, Q., Snell, W. J. & Nes, W. D., Aug 2012, In: Journal of lipid research. 53, 8, p. 1636-1645 10 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2011

The phosphorylation state of an aurora-like kinase marks the length of growing flagella in Chlamydomonas

Luo, M., Cao, M., Kan, Y., Li, G., Snell, W. & Pan, J., Apr 12 2011, In: Current Biology. 21, 7, p. 586-591 6 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2010

Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas

Liu, Y., Misamore, M. J. & Snell, W. J., May 1 2010, In: Development. 137, 9, p. 1473-1481 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2009

A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas

Piao, T., Luo, M., Wang, L., Guo, Y., Li, D., Li, P., Snell, W. J. & Pan, J., Mar 24 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4713-4718 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

109 Scopus citations

Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm

Ellerman, D. A., Pei, J., Gupta, S., Snell, W. J., Myles, D. & Primakoff, P., Dec 2009, In: Molecular Reproduction and Development. 76, 12, p. 1188-1199 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

2008

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

Liu, Y., Tewari, R., Ning, J., Blagborough, A. M., Garbom, S., Pei, J., Grishin, N. V., Steele, R. E., Sinden, R. E., Snell, W. J. & Billker, O., Apr 15 2008, In: Genes and Development. 22, 8, p. 1051-1068 18 p.

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

2006

Intraflagellar Transport Particles Participate Directly in Cilium-Generated Signaling in Chlamydomonas

Wang, Q., Pan, J. & Snell, W. J., May 5 2006, In: Cell. 125, 3, p. 549-562 14 p.

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

2005

Chlamydomonas shortens its flagella by activating axonemal disassembly, stimulating IFT particle trafficking, and blocking anterograde cargo loading

Pan, J. & Snell, W. J., Sep 2005, In: Developmental cell. 9, 3, p. 431-438 8 p.

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

2004

An aurora kinase is essential for flagellar disassembly in Chlamydomonas

Pan, J., Wang, Q. & Snell, W. J., Mar 2004, In: Developmental cell. 6, 3, p. 445-451 7 p.

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

2003

Flagellar adhesion between mating type plus and mating type minus gametes activates a flagellar protein-tyrosine kinase during fertilization in Chlamydomonas

Wang, Q. & Snell, W. J., Aug 29 2003, In: Journal of Biological Chemistry. 278, 35, p. 32936-32942 7 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

The Chlamydomonas Fus1 protein is present on the mating type plus fusion organelle and required for a critical membrane adhesion event during fusion with minus gametes

Misamore, M. J., Gupta, S. & Snell, W. J., Jun 1 2003, In: Molecular biology of the cell. 14, 6, p. 2530-2542 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

2002

An algal nucleus-encoded subunit of mitochondrial ATP synthase rescues a defect in the analogous human mitochondrial-encoded subunit

Ojaimi, J., Pan, J., Santra, S., Snell, W. J. & Schon, E. A., Nov 1 2002, In: Molecular biology of the cell. 13, 11, p. 3836-3844 9 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas

Pan, J. & Snell, W. J., 2002, In: Molecular biology of the cell. 13, 4, p. 1417-1426 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

2001

Ectopic expression of a Chlamydomonas mt+-specific homeodomain protein in mt- gametes initiates zygote development without gamete fusion

Zhao, H., Lu, M., Singh, R. & Snell, W. J., Oct 15 2001, In: Genes and Development. 15, 20, p. 2767-2777 11 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2000

Regulated targeting of a protein kinase into a intact flagellum: An aurora/IpI1p-like protein kinase translocates from the cell body into the flagella during gamete activation in Chlamydomonas

Pan, J. & Snell, W. J., Aug 4 2000, In: Journal of Biological Chemistry. 275, 31, p. 24106-24114 9 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

1999

Flagellar adhesion between mt⁺ and mt^- Chlamydomonas gametes regulates phosphorylation of the mt⁺-specific homeodomain protein GSP1

Wilson, N. F., O'Connell, J. S., Lu, M. & Snell, W. J., Nov 26 1999, In: Journal of Biological Chemistry. 274, 48, p. 34383-34388 6 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

1998

A gamete-specific, sex-limited homeodomain protein in Chlamydomonas

Kurvari, V., Grishin, N. V. & Snell, W. J., Dec 28 1998, In: Journal of Cell Biology. 143, 7, p. 1971-1980 10 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Microvilli and cell-cell fusion during fertilization

Wilson, N. F. & Snell, W. J., Mar 1998, In: Trends in Cell Biology. 8, 3, p. 93-96 4 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

1997

The Chlamydomonas mating type plus fertilization tubule, a prototypic cell fusion organelle: Isolation, characterization, and in vitro adhesion to mating type minus gametes

Wilson, N. F., Foglesong, M. J. & Snell, W. J., Jun 30 1997, In: Journal of Cell Biology. 137, 7, p. 1537-1553 17 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

1996

Cell adhesion-dependent inactivation of a soluble protein kinase during fertilization in Chlamydomonas

Zhang, Y., Luo, Y., Emmett, K. & Snell, W. J., Apr 1996, In: Molecular biology of the cell. 7, 4, p. 515-527 13 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Molecular cloning of a protein kinase whose phosphorylation is regulated by gametic adhesion during Chlamydomonas fertilization

Kurvari, V., Zhang, Y., Luo, Y. & Snell, W. J., Jan 9 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 1, p. 39-43 5 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

SksC, a fertilization-related protein kinase in chlamydomonas, is expressed throughout the cell cycle and gametogenesis, and a phosphorylated form is present in both flagella and cell bodies

Kurvari, V. & Snell, W. J., Nov 1 1996, In: Biochemical and Biophysical Research Communications. 228, 1, p. 45-54 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

1995

Chapter 64 Flagellar Adenylyl Cyclases in Chlamydomonas

Zhang, Y. & Snell, W. J., Jan 1 1995, In: Methods in cell biology. 47, C, p. 459-465 7 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Increased transcript levels of a methionine synthase during adhesion-induced activation of Chlamydomonas reinhardtii gametes

Kurvari, V., Qian, F. & Snell, W. J., Dec 1995, In: Plant Molecular Biology. 29, 6, p. 1235-1252 18 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

1994

Flagellar adhesion-dependent regulation of Chlamydomonas adenylyl cyclase in vitro: A possible role for protein kinases in sexual signaling

Zhang, Y. & Snell, W. J., May 1994, In: Journal of Cell Biology. 125, 3, p. 617-624 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

1993

Differential regulation of adenylylcyclases in vegetative and gametic flagella of Chlamydomonas

Zhang, Y. & Snell, W. J., Jan 25 1993, In: Journal of Biological Chemistry. 268, 3, p. 1786-1791 6 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

1992

Inositol phospholipid metabolism may trigger flagellar excision in Chlamydomonas reinhardtii

Quarmby, L. M., Yueh, Y. G., Cheshire, J. L., Keller, L. R., Snell, W. J. & Crain, R. C., Feb 1992, In: Journal of Cell Biology. 116, 3, p. 737-744 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Scopus citations

1991

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii

Zhang, Y., Ross, E. M. & Snell, W. J., Dec 5 1991, In: Journal of Biological Chemistry. 266, 34, p. 22954-22959 6 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Rapid and slow mechanisms for loss of cell adhesiveness during fertilization in Chlamydomonas

Hunnicutt, G. R. & Snell, W. J., Sep 1991, In: Developmental Biology. 147, 1, p. 216-224 9 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

1990

Adhesion and signalling during fertilization in multicellular and unicellular organisms

Snell, W. J., Oct 1990, In: Current Opinion in Cell Biology. 2, 5, p. 821-832 12 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Cell body and flagellar agglutinins in Chlamydomonas reinhardtii: The cell body plasma membrane is a reservoir for agglutinins whose migration to the flagella is regulated by a functional barrier

Hunnicutt, G. R., Kosfiszer, M. G. & Snell, W. J., Oct 1990, In: Journal of Cell Biology. 111, 4, p. 1605-1616 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

1989

Activation of the cell wall degrading protease, lysin, during sexual signalling in Chlamydomonas: the enzyme is stored as an inactive, higher relative molecular mass precursor in the periplasm.

Buchanan, M. J., Imam, S. H., Eskue, W. A. & Snell, W. J., Jan 1989, In: The Journal of cell biology. 108, 1, p. 199-207 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Regulated secretion of a serine protease that activates an extracellular matrix-degrading metalloprotease during fertilization in Chlamydomonas.

Snell, W. J., Eskue, W. A. & Buchanan, M. J., Oct 1989, In: The Journal of cell biology. 109, 4 Pt 1, p. 1689-1694 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

1988

Biochemical studies on lysin, a cell wall degrading enzyme released during fertilization in Chlamydomonas

Buchanan, M. J. & Snell, W. J., Nov 1988, In: Experimental Cell Research. 179, 1, p. 181-193 13 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

The Chlamydomonas cell wall degrading enzyme, lysin, acts on two substrates within the framework of the wall

Imam, S. H. & Snell, W. J., 1988, In: Journal of Cell Biology. 106, 6, p. 2211-2221 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

1987

Degradation of the framework of the Chlamydomonas cell wall by proteases present in a commercially available alpha-amylase preparation.

Imam, S. H. & Snell, W. J., Jul 1987, In: Applied and environmental microbiology. 53, 7, p. 1701-1704 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

1986

A monoclonal antibody that blocks adhesion of chlamydomonas mt⁺ gametes

Snell, W. J., Kosfiszer, M. G., Clausell, A., Perillo, N., Imam, S. & Hunnicutt, G., Dec 1 1986, In: Journal of Cell Biology. 103, 6, p. 2449-2456 8 p.

Research output: Contribution to journal › Article › peer-review