Research output per year
Research output per year
- 1 - 50 out of 51 results
Search results
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2024
SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport
Makio, T., Zhang, K., Love, N., Mast, F. D., Liu, X., Elaish, M., Hobman, T., Aitchison, J. D., Fontoura, B. M. A. & Wozniak, R. W., May 1 2024, In: Molecular biology of the cell. 35, 5, p. ar62Research output: Contribution to journal › Article › peer-review
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2023
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Kehrer, T., Cupic, A., Ye, C., Yildiz, S., Bouhaddou, M., Crossland, N. A., Barrall, E. A., Cohen, P., Tseng, A., Çağatay, T., Rathnasinghe, R., Flores, D., Jangra, S., Alam, F., Mena, I., Aslam, S., Saqi, A., Rutkowska, M., Ummadi, M. R., Pisanelli, G., & 20 others, Oct 11 2023, In: Cell Host and Microbe. 31, 10, p. 1668-1684.e12Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
Bhat, P., Aksenova, V., Gazzara, M., Rex, E. A., Aslam, S., Haddad, C., Gao, S., Esparza, M., Cagatay, T., Batten, K., El Zahed, S. S., Arnaoutov, A., Zhong, H., Shay, J. W., Tolbert, B. S., Dasso, M., Lynch, K. W., García-Sastre, A. & Fontoura, B. M. A., Dec 2023, In: Nature communications. 14, 1, 2304.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly
Xie, Y., Gao, S., Zhang, K., Bhat, P., Clarke, B. P., Batten, K., Mei, M., Gazzara, M., Shay, J. W., Lynch, K. W., Angelos, A. E., Hill, P. S., Ivey, A. L., Fontoura, B. & Ren, Y., Aug 29 2023, In: Cell Reports. 42, 8, 112988.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2022
Nuclear speckle integrity and function require TAO2 kinase
Gao, S., Esparza, M., Dehghan, I., Aksenova, V., Zhang, K., Batten, K., Ferretti, M. B., Begg, B. E., Cagatay, T., Shay, J. W., Garcıa-Sastre, A., Goldsmith, E. J., Chen, Z. J., Dasso, M., Lynch, K. W., Cobb, M. H. & Fontoura, B. M. A., Jun 21 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 25, e2206046119.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2021
Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein
White, K., Esparza, M., Liang, J., Bhat, P., Naidoo, J., McGovern, B. L., Williams, M. A. P., Alabi, B. R., Shay, J., Niederstrasser, H., Posner, B., García-Sastre, A., Ready, J. & Fontoura, B. M. A., Aug 12 2021, In: Journal of Medicinal Chemistry. 64, 15, p. 10951-10966 16 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
Zhang, K., Miorin, L., Makio, T., Dehghan, I., Gao, S., Xie, Y., Zhong, H., Esparza, M., Kehrer, T., Kumar, A., Hobman, T. C., Ptak, C., Gao, B., Minna, J. D., Chen, Z., García-Sastre, A., Ren, Y., Wozniak, R. W. & Fontoura, B. M. A., Feb 5 2021, In: Science Advances. 7, 6, eabe7386.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
2020
Chemical intervention of influenza virus mRNA nuclear export
Esparza, M., Mor, A., Niederstrasser, H., White, K., White, A., Zhang, K., Gao, S., Wang, J., Liang, J., Sho, S., Sakthivel, R., Sathe, A. A., Xing, C., Muñoz-Moreno, R., Shay, J. W., García-Sastre, A., Ready, J., Posner, B. & Fontoura, B. M. A., Apr 1 2020, In: PLoS pathogens. 16, 4, e1008407.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
Aksenova, V., Smith, A., Lee, H., Bhat, P., Esnault, C., Chen, S., Iben, J., Kaufhold, R., Yau, K. C., Echeverria, C., Fontoura, B., Arnaoutov, A. & Dasso, M., Dec 1 2020, In: Nature communications. 11, 1, 4577.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
Miorin, L., Kehrer, T., Sanchez-Aparicio, M. T., Zhang, K., Cohen, P., Patel, R. S., Cupic, A., Makio, T., Mei, M., Moreno, E., Danziger, O., White, K. M., Rathnasinghe, R., Uccellini, M., Gao, S., Aydillo, T., Mena, I., Yin, X., Martin-Sancho, L., Krogan, N. J., & 7 others, Nov 10 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 45, p. 28344-28354 11 p.Research output: Contribution to journal › Article › peer-review
Open Access327 Scopus citations -
Viral-induced alternative splicing of host genes promotes influenza replication
Thompson, M. G., Dittmar, M., Mallory, M. J., Bhat, P., Ferretti, M. B., Fontoura, B. M., Cherry, S. & Lynch, K. W., Dec 2020, In: eLife. 9, p. 1-20 20 p., e55500.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
2019
DEAD-box ATPases are global regulators of phase-separated organelles
Hondele, M., Sachdev, R., Heinrich, S., Wang, J., Vallotton, P., Fontoura, B. M. A. & Weis, K., Sep 5 2019, In: Nature. 573, 7772, p. 144-148 5 p.Research output: Contribution to journal › Article › peer-review
218 Scopus citations -
Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
Liu, Z., Yan, M., Liang, Y., Liu, M., Zhang, K., Shao, D., Jiang, R., Li, L., Wang, C., Nussenzveig, D. R., Zhang, K., Chen, S., Zhong, C., Mo, W., Fontoura, B. M. A. & Zhang, L., May 8 2019, In: Neuron. 102, 3, p. 587-601.e7Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
2018
Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
Thompson, M. G., Muñoz-Moreno, R., Bhat, P., Roytenberg, R., Lindberg, J., Gazzara, M. R., Mallory, M. J., Zhang, K., García-Sastre, A., Fontoura, B. M. A. & Lynch, K. W., Dec 1 2018, In: Nature communications. 9, 1, 2407.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
Günter Blobel 1936-2018
Chook, Y. M., Fontoura, B. M. A. & Rout, M. P., Apr 1 2018, In: Nature structural & molecular biology. 25, 4, p. 297-298 2 p.Research output: Contribution to journal › Article › peer-review
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Influenza virus NS1 protein-RNA interactome reveals intron targeting
Zhang, L., Wang, J., Muñoz-Moreno, R., Kim, M., Sakthivel, R., Mo, W., Shao, D., Anantharaman, A., García-Sastre, A., Conrad, N. K. & Fontoura, B. M., Dec 1 2018, In: Journal of virology. 92, 24, e0163418.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression
Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2017
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
Kuss-Duerkop, S. K., Wang, J., Mena, I., White, K., Metreveli, G., Sakthivel, R., Mata, M. A., Muñoz-Moreno, R., Chen, X., Krammer, F., Diamond, M. S., Chen, Z. J., García-Sastre, A. & Fontoura, B. M. A., Sep 2017, In: PLoS pathogens. 13, 9, e1006635.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
2016
Influenza virus mRNA trafficking through host nuclear speckles
Mor, A., White, A., Zhang, K., Thompson, M., Esparza, M., Muñoz-Moreno, R., Koide, K., Lynch, K. W., García-Sastre, A. & Fontoura, B. M. A., May 27 2016, In: Nature microbiology. 1, 7, 16069.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages
Zhang, M., Mishra, S., Sakthivel, R., Fontoura, B. M. A. & Nussenzweig, V., 2016, In: PLoS pathogens. 12, 1, e1005370.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2015
Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo
Moreira, T. G., Zhang, L., Shaulov, L., Harel, A., Kuss, S. K., Williams, J., Shelton, J., Somatilaka, B., Seemann, J., Yang, J., Sakthivel, R., Nussenzveig, D. R., Faria, A. M. C. & Fontoura, B. M. A., Dec 3 2015, In: Scientific reports. 5, 17655.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2014
Primate-specific miR-576-3p sets host defense signalling threshold
Yarbrough, M. L., Zhang, K., Sakthivel, R., Forst, C. V., Posner, B. A., Barber, G. N., White, M. A. & Fontoura, B. M. A., 2014, In: Nature communications. 5, 4963.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
2013
Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing
Tsai, P. L., Chiou, N. T., Kuss, S., García-Sastre, A., Lynch, K. W. & Fontoura, B. M. A., Jun 2013, In: PLoS pathogens. 9, 6, e1003460.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
SAR-based optimization of a 4-quinoline carboxylic acid analogue with potent antiviral activity
Das, P., Deng, X., Zhang, L., Roth, M. G., Fontoura, B. M. A., Phillips, M. A. & De Brabander, J. K., Jun 13 2013, In: ACS Medicinal Chemistry Letters. 4, 6, p. 517-521 5 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
2012
Host modulators of H1N1 cytopathogenicity
Ward, S. E., Kim, H. S., Komurov, K., Mendiratta, S., Tsai, P. L., Schmolke, M., Satterly, N., Manicassamy, B., Forst, C. V., Roth, M. G., García-Sastre, A., Blazewska, K. M., McKenna, C. E., Fontoura, B. M. & White, M. A., Aug 2 2012, In: PloS one. 7, 8, e39284.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
Zhang, L., Das, P., Schmolke, M., Manicassamy, B., Wang, Y., Deng, X., Cai, L., Tu, B. P., Forst, C. V., Roth, M. G., Levy, D. E., García-Sastre, A., de Brabander, J., Phillips, M. A. & Fontoura, B. M. A., Feb 6 2012, In: Journal of Cell Biology. 196, 3, p. 315-326 12 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
2011
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor
Mata, M. A., Satterly, N., Versteeg, G. A., Frantz, D., Wei, S., Williams, N., Schmolke, M., Peña-Llopis, S., Brugarolas, J., Forst, C. V., White, M. A., García-Sastre, A., Roth, M. G. & Fontoura, B. M. A., Oct 2011, In: Nature chemical biology. 7, 10, p. 712-719 8 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1
Zhang, Z. C., Satterly, N., Fontoura, B. M. A. & Chook, Y. M., Dec 1 2011, In: Molecular biology of the cell. 22, 23, p. 4657-4668 12 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
2010
The Nup107-160 complex and γ-TuRC regulate microtubule polymerization at kinetochores
Mishra, R. K., Chakraborty, P., Arnaoutov, A., Fontoura, B. M. A. & Dasso, M., Feb 2010, In: Nature cell biology. 12, 2, p. 164-169 6 p.Research output: Contribution to journal › Article › peer-review
Open Access152 Scopus citations -
The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands
Zhang, M., Fennell, C., Ranford-Cartwright, L., Sakthivel, R., Gueirard, P., Meister, S., Caspi, A., Doerig, C., Nussenzweig, R. S., Tuteja, R., Sullivan, W. J., Roos, D. S., Fontoura, B. M. A., Ménard, R., Winzeler, E. A. & Nussenzweig, V., Jul 5 2010, In: Journal of Experimental Medicine. 207, 7, p. 1465-1474 10 p.Research output: Contribution to journal › Article › peer-review
103 Scopus citations -
2009
Vesicular stomatitis virus inhibits mitotic progression and triggers cell death
Chakraborty, P., Seemann, J., Mishra, R. K., Wei, J. H., Weil, L., Nussenzveig, D. R., Heiber, J., Barber, G. N., Dasso, M. & Fontoura, B. M. A., 2009, In: EMBO Reports. 10, 10, p. 1154-1160 7 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2008
NFAR-1 and -2 modulate translation and are required for efficient host defense
Pfeifer, I., Elsby, R., Fernandez, M., Faria, P. A., Nussenzveig, D. R., Lossos, I. S., Fontoura, B. M. A., Martin, W. D. & Barber, G. N., Mar 18 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 11, p. 4173-4178 6 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
Nucleoporin Levels Regulate Cell Cycle Progression and Phase-Specific Gene Expression
Chakraborty, P., Wang, Y., Wei, J. H., van Deursen, J., Yu, H., Malureanu, L., Dasso, M., Forbes, D. J., Levy, D. E., Seemann, J. & Fontoura, B. M. A., Nov 11 2008, In: Developmental cell. 15, 5, p. 657-667 11 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
2007
Influenza virus targets the mRNA export machinery and the nuclear pore complex
Satterly, N., Tsai, P. L., Van Deursen, J., Nussenzveig, D. R., Wang, Y., Faria, P. A., Levay, A., Levy, D. E. & Fontoura, B. M. A., Feb 6 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1853-1858 6 p.Research output: Contribution to journal › Article › peer-review
Open Access243 Scopus citations -
Plasmodium Circumsporozoite Protein Promotes the Development of the Liver Stages of the Parasite
Singh, A. P., Buscaglia, C. A., Wang, Q., Levay, A., Nussenzweig, D. R., Walker, J. R., Winzeler, E. A., Fujii, H., Fontoura, B. M. A. & Nussenzweig, V., Nov 2 2007, In: Cell. 131, 3, p. 492-504 13 p.Research output: Contribution to journal › Article › peer-review
173 Scopus citations -
Structure-based design of a pathway-specific nuclear import inhibitor
Cansizoglu, A. E., Lee, B. J., Zhang, Z. C., Fontoura, B. M. A. & Chook, Y. M., May 2007, In: Nature Structural and Molecular Biology. 14, 5, p. 452-454 3 p.Research output: Contribution to journal › Article › peer-review
135 Scopus citations -
2006
Nuclear export assays for poly(A) RNAs
Chakraborty, P., Satterly, N. & Fontoura, B. M. A., Aug 2006, In: Methods. 39, 4, p. 363-369 7 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions
Faria, A. M. C., Levay, A., Wang, Y., Kamphorst, A. O., Rosa, M. L. P., Nussenzveig, D. R., Balkan, W., Chook, Y. M., Levy, D. E. & Fontoura, B. M. A., Mar 2006, In: Immunity. 24, 3, p. 295-304 10 p.Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly
Orjalo, A. V., Arnaoutov, A., Shen, Z., Boyarchuk, Y., Zeitlin, S. G., Fontoura, B., Briggs, S., Dasso, M. & Forbes, D. J., Sep 2006, In: Molecular biology of the cell. 17, 9, p. 3806-3818 13 p.Research output: Contribution to journal › Article › peer-review
Open Access125 Scopus citations -
2005
VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway
Faria, P. A., Chakraborty, P., Levay, A., Barber, G. N., Ezelle, H. J., Enninga, J., Arana, C., Van Deursen, J. & Fontoura, B. M. A., Jan 7 2005, In: Molecular cell. 17, 1, p. 93-102 10 p.Research output: Contribution to journal › Article › peer-review
195 Scopus citations -
2003
Cytoplasmic complex of p53 and eEF2
Yin, X., Fontoura, B. M. A., Morimoto, T. & Carroll, R. B., Sep 1 2003, In: Journal of cellular physiology. 196, 3, p. 474-482 9 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex
Enninga, J., Levay, A. & Fontoura, B. M. A., Oct 2003, In: Molecular and cellular biology. 23, 20, p. 7271-7284 14 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
2002
Role of nucleoporin induction in releasing an mRNA nuclear export block
Enninga, J., Levy, D. E., Blobel, G. & Fontoura, B. M. A., Feb 22 2002, In: Science. 295, 5559, p. 1523-1525 3 p.Research output: Contribution to journal › Article › peer-review
136 Scopus citations -
2001
The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR
Fontoura, B. M. A., Dales, S., Blobel, G. & Zhong, H., Mar 13 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 6, p. 3208-3213 6 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
2000
The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin β2-mediated nuclear import
Fontoura, B. M. A., Blobel, G. & Yaseen, N. R., Oct 6 2000, In: Journal of Biological Chemistry. 275, 40, p. 31289-31296 8 p.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
1999
A conserved biogenesis pathway for nucleoporins: Proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96
Fontoura, B. M. A., Blobel, G. & Matunis, M. J., Mar 22 1999, In: Journal of Cell Biology. 144, 6, p. 1097-1112 16 p.Research output: Contribution to journal › Article › peer-review
206 Scopus citations -
1997
Cytoplasmic p53 polypeptide is associated with ribosomes
Fontoura, B. M. A., Atienza, C. A., Sorokina, E. A., Morimoto, T. & Carroll, R. B., Jun 1997, In: Molecular and cellular biology. 17, 6, p. 3146-3154 9 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
1992
p53 is covalently linked to 5.8S rRNA
Fontoura, B. M. A., Sorokina, E. A., David, E. & Carroll, R. B., Nov 1992, In: Molecular and cellular biology. 12, 11, p. 5145-5151 7 p.Research output: Contribution to journal › Article › peer-review
97 Scopus citations -
1991
Dup 753 is a potent nonpeptide antagonist of angiotensin ii receptors in isolated perfused rat kidney and cultured renal cells
Fontoura, B. M. A., Nussenzveig, D. R., Timmermans, P. B. M. W. M. & Maack, T., Apr 1991, In: American Journal of Hypertension. 4, 4, p. 303s-308sResearch output: Contribution to journal › Article › peer-review
31 Scopus citations -
Nitric oxide synthesis from L-arginine modulates renal vascular resistance in isolated perfused and intact rat kidneys
Welch, W. J., Wilcox, C. S., Aisaka, K., Gross, S. S., Griffith, O. W., Fontoura, B. M. A., Maack, T. & Levi, R., Jan 1 1991, In: Journal of Cardiovascular Pharmacology. 17, SUPPL. 3, p. S165-S168Research output: Contribution to journal › Article › peer-review
39 Scopus citations