@article{8a63766218cc49e991884619ad688b5a,
title = "Structure-based design of a pathway-specific nuclear import inhibitor",
abstract = "Kapβ2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx(2-5)PY motif. Here we show that Kapβ2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapβ2-specific nuclear import inhibitor, M9M.",
author = "Cansizoglu, {Ahmet E.} and Lee, {Brittany J.} and Zhang, {Zi Chao} and Fontoura, {Beatriz M A} and Chook, {Yuh Min}",
note = "Funding Information: We thank the University of Texas Southwestern{\textquoteright}s Structural Biology Laboratory, C. Thomas, N. Satterly, M. Matunis, M. Swanson, H. Yu, E. Seto and R. Bassel-Duby. The US Department of Energy, Offices of Science and Basic Energy Sciences (contract W-31-109-ENG-38) supported Advanced Photon Source use. Y.M.C. is funded by US National Institutes of Health grant R01-GM069909, Welch Foundation grant I-1532 and the University of Texas Southwestern Endowed Scholars Program, B.M.A.F. by US National Institutes of Health grant R01-GM067159-01.",
year = "2007",
month = may,
doi = "10.1038/nsmb1229",
language = "English (US)",
volume = "14",
pages = "452--454",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
number = "5",
}