X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma, Xiaoju Zou, Brian Bui, Wei Chen, Kwang Hyun Song, Timothy Solberg

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

Original languageEnglish (US)
Article number013702
JournalApplied Physics Letters
Issue number1
StatePublished - Jul 7 2014

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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