Wnt signaling in cancer pathogenesis and therapeutics

Naoko Takebe; Lawrence Lum; S. Percy Ivy

doi:10.1007/978-1-4614-1216-8_6

Wnt signaling in cancer pathogenesis and therapeutics

Naoko Takebe, Lawrence Lum, S. Percy Ivy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

This chapter presents a concise review of Wnt signaling in cancer pathogenesis. Our focus is on the description of novel agents in preclinical and/or clinical stage development, which inhibit dysfunctional Wnt signaling. We discuss growing evidence that the Wnt pathway supports cellular proliferation by sustaining renewal of cancer initiating stem cells. We also review ongoing therapeutic efforts to inhibit pathway activity in a broad range of cancers. The rationale for targeting this pathway is well justified, based on the association of colorectal cancer with deregulation of Wnt signaling. Therefore, the Wnt pathway may represent an important target for the development of novel anticancer therapeutics.

Original language	English (US)
Title of host publication	Signaling Pathways in Cancer Pathogenesis and Therapy
Publisher	Springer New York
Pages	81-94
Number of pages	14
ISBN (Electronic)	9781461412168
ISBN (Print)	1461412153, 9781461412151
DOIs	https://doi.org/10.1007/978-1-4614-1216-8_6
State	Published - Aug 1 2013
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-1216-8_6

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abstract = "This chapter presents a concise review of Wnt signaling in cancer pathogenesis. Our focus is on the description of novel agents in preclinical and/or clinical stage development, which inhibit dysfunctional Wnt signaling. We discuss growing evidence that the Wnt pathway supports cellular proliferation by sustaining renewal of cancer initiating stem cells. We also review ongoing therapeutic efforts to inhibit pathway activity in a broad range of cancers. The rationale for targeting this pathway is well justified, based on the association of colorectal cancer with deregulation of Wnt signaling. Therefore, the Wnt pathway may represent an important target for the development of novel anticancer therapeutics.",

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AU - Ivy, S. Percy

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AB - This chapter presents a concise review of Wnt signaling in cancer pathogenesis. Our focus is on the description of novel agents in preclinical and/or clinical stage development, which inhibit dysfunctional Wnt signaling. We discuss growing evidence that the Wnt pathway supports cellular proliferation by sustaining renewal of cancer initiating stem cells. We also review ongoing therapeutic efforts to inhibit pathway activity in a broad range of cancers. The rationale for targeting this pathway is well justified, based on the association of colorectal cancer with deregulation of Wnt signaling. Therefore, the Wnt pathway may represent an important target for the development of novel anticancer therapeutics.

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BT - Signaling Pathways in Cancer Pathogenesis and Therapy

PB - Springer New York

ER -

Wnt signaling in cancer pathogenesis and therapeutics

Abstract

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