WNKs: Protein kinases with a unique kinase domain

Chou Long Huang, Seung Kuy Cha, Hao Ran Wang, Jian Xie, Melanie H. Cobb

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.

Original languageEnglish (US)
Pages (from-to)565-573
Number of pages9
JournalExperimental and Molecular Medicine
Issue number5
StatePublished - Oct 31 2007


  • Genome, human
  • Hyperkalemia
  • Hypertension
  • Neoplasms
  • Protein kinases
  • Pseudohypoaldosteronisms
  • WNK1 protein, human

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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