WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

Sachith Gallolu Kankanamalage; Aroon S. Karra; Melanie H Cobb

doi:10.1186/s12964-018-0287-1

WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

Sachith Gallolu Kankanamalage, Aroon S. Karra, Melanie H Cobb

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters. Main body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Conclusion: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis.

Original language	English (US)
Article number	72
Journal	Cell Communication and Signaling
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12964-018-0287-1
State	Published - Nov 3 2018

Keywords

And NF-κB
Cancer
Cellular signaling
Ion transport
OSR1
PI3K-AKT
SPAK
STK39
TGF-β
WNKs

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1186/s12964-018-0287-1

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title = "WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology",

abstract = "Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters. Main body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Conclusion: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis.",

keywords = "And NF-κB, Cancer, Cellular signaling, Ion transport, OSR1, PI3K-AKT, SPAK, STK39, TGF-β, WNKs",

author = "{Gallolu Kankanamalage}, Sachith and Karra, {Aroon S.} and Cobb, {Melanie H}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = nov,

day = "3",

doi = "10.1186/s12964-018-0287-1",

language = "English (US)",

volume = "16",

journal = "Cell Communication and Signaling",

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TY - JOUR

T1 - WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

AU - Gallolu Kankanamalage, Sachith

AU - Karra, Aroon S.

AU - Cobb, Melanie H

PY - 2018/11/3

Y1 - 2018/11/3

N2 - Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters. Main body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Conclusion: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis.

AB - Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters. Main body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Conclusion: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis.

KW - And NF-κB

KW - Cancer

KW - Cellular signaling

KW - Ion transport

KW - OSR1

KW - PI3K-AKT

KW - SPAK

KW - STK39

KW - TGF-β

KW - WNKs

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U2 - 10.1186/s12964-018-0287-1

DO - 10.1186/s12964-018-0287-1

M3 - Review article

C2 - 30390653

AN - SCOPUS:85056140997

SN - 1478-811X

VL - 16

JO - Cell Communication and Signaling

JF - Cell Communication and Signaling

IS - 1

M1 - 72

ER -

WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

Abstract

Keywords

ASJC Scopus subject areas

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