TY - JOUR
T1 - Wisconsin card sorting activated regional cerebral blood flow in first break and chronic schizophrenic patients and normal controls
AU - Steinberg, Joel L.
AU - Devous, Michael D.
AU - Paulman, Ronald G.
N1 - Funding Information:
This research was supported by the Veterans Administration Merit Review and the John C. Schermerhorn Fund. We thank Rodrick R. Gregory, Joachim D. Raese, and Timothy Wolff for their contributions to this study. We also thank D. Robert Fowler and Kenneth Z. Altshuler for their support. We gratefully acknowledge the excellent technical assistance provided by Janie Childers, J. Kelly Payne, and Lisa K. Sharp.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/5
Y1 - 1996/5
N2 - Dynamic 133Xe single photon emission computed tomography (SPECT) was used to measure regional cerebral blood flow (rCBF) during the Wisconsin Card Sorting test (WCS) and the Number Matching task (NM) in six never-medicated first break schizophrenic and schizophreniform patients, seven chronic schizophrenic patients, and seven normal controls. Because of a difference in mean age between first break patients and normals, we adjusted rCBF data for age effects using ANCOVA. For age-adjusted absolute superior and middle frontal rCBF bilaterally, we found significantly less activation from NM to WCS in first break patients compared to normals. Similarly, for age-adjusted absolute and relative left middle frontal rCBF, we found significantly less activation in chronics compared to normals. Changes in age-adjusted global cerebral blood flow (gCBF) were not statistically significant among the three groups, but were in the same direction as activated absolute frontal rCBF. Because of the small number of subjects in each group, the results of this study should be regarded as preliminary and interpreted cautiously.
AB - Dynamic 133Xe single photon emission computed tomography (SPECT) was used to measure regional cerebral blood flow (rCBF) during the Wisconsin Card Sorting test (WCS) and the Number Matching task (NM) in six never-medicated first break schizophrenic and schizophreniform patients, seven chronic schizophrenic patients, and seven normal controls. Because of a difference in mean age between first break patients and normals, we adjusted rCBF data for age effects using ANCOVA. For age-adjusted absolute superior and middle frontal rCBF bilaterally, we found significantly less activation from NM to WCS in first break patients compared to normals. Similarly, for age-adjusted absolute and relative left middle frontal rCBF, we found significantly less activation in chronics compared to normals. Changes in age-adjusted global cerebral blood flow (gCBF) were not statistically significant among the three groups, but were in the same direction as activated absolute frontal rCBF. Because of the small number of subjects in each group, the results of this study should be regarded as preliminary and interpreted cautiously.
KW - Frontal cortex
KW - Regional cerebral blood flow
KW - Schizophrenia
KW - Sing photon emission computed tomography
KW - Wisconsin Card Sorting Test
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U2 - 10.1016/0920-9964(96)88525-2
DO - 10.1016/0920-9964(96)88525-2
M3 - Article
C2 - 8789916
AN - SCOPUS:0029895405
SN - 0920-9964
VL - 19
SP - 177
EP - 187
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -