Widespread decrease of nicotinic acetylcholine receptors in Parkinson's Disease

Masahiro Fujita; Masanori Ichise; Sami S. Zoghbi; Jeih San Liow; Subroto Ghose; Douglass C. Vines; Janet Sangare; Jian Qiang Lu; Vanessa L. Cropley; Hidehiro Iida; Kyeong Min Kim; Robert M. Cohen; William Bara-Jimenez; Bernard Ravina; Robert B. Innis

doi:10.1002/ana.20688

Widespread decrease of nicotinic acetylcholine receptors in Parkinson's Disease

Masahiro Fujita, Masanori Ichise, Sami S. Zoghbi, Jeih San Liow, Subroto Ghose, Douglass C. Vines, Janet Sangare, Jian Qiang Lu, Vanessa L. Cropley, Hidehiro Iida, Kyeong Min Kim, Robert M. Cohen, William Bara-Jimenez, Bernard Ravina, Robert B. Innis

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [¹²³I] 5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K₁). Results: Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K₁. Interpretation: These results indicate the importance of extending the study to demented patients.

Original language	English (US)
Pages (from-to)	174-177
Number of pages	4
Journal	Annals of Neurology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1002/ana.20688
State	Published - Jan 2006

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Widespread decrease of nicotinic acetylcholine receptors in Parkinson's Disease",

abstract = "Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [123I] 5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K1). Results: Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K1. Interpretation: These results indicate the importance of extending the study to demented patients.",

author = "Masahiro Fujita and Masanori Ichise and Zoghbi, {Sami S.} and Liow, {Jeih San} and Subroto Ghose and Vines, {Douglass C.} and Janet Sangare and Lu, {Jian Qiang} and Cropley, {Vanessa L.} and Hidehiro Iida and Kim, {Kyeong Min} and Cohen, {Robert M.} and William Bara-Jimenez and Bernard Ravina and Innis, {Robert B.}",

year = "2006",

month = jan,

doi = "10.1002/ana.20688",

language = "English (US)",

volume = "59",

pages = "174--177",

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T1 - Widespread decrease of nicotinic acetylcholine receptors in Parkinson's Disease

AU - Fujita, Masahiro

AU - Ichise, Masanori

AU - Zoghbi, Sami S.

AU - Liow, Jeih San

AU - Ghose, Subroto

AU - Vines, Douglass C.

AU - Sangare, Janet

AU - Lu, Jian Qiang

AU - Cropley, Vanessa L.

AU - Iida, Hidehiro

AU - Kim, Kyeong Min

AU - Cohen, Robert M.

AU - Bara-Jimenez, William

AU - Ravina, Bernard

AU - Innis, Robert B.

PY - 2006/1

Y1 - 2006/1

N2 - Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [123I] 5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K1). Results: Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K1. Interpretation: These results indicate the importance of extending the study to demented patients.

AB - Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [123I] 5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K1). Results: Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K1. Interpretation: These results indicate the importance of extending the study to demented patients.

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Widespread decrease of nicotinic acetylcholine receptors in Parkinson's Disease

Abstract

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