Why does obesity cause diabetes?

Samuel Klein, Amalia Gastaldelli, Hannele Yki-Järvinen, Philipp E. Scherer

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalCell Metabolism
Issue number1
StatePublished - Jan 4 2022

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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