Why does obesity cause diabetes?

Samuel Klein; Amalia Gastaldelli; Hannele Yki-Järvinen; Philipp E. Scherer

doi:10.1016/j.cmet.2021.12.012

Why does obesity cause diabetes?

Samuel Klein, Amalia Gastaldelli, Hannele Yki-Järvinen, Philipp E. Scherer

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.

Original language	English (US)
Pages (from-to)	11-20
Number of pages	10
Journal	Cell Metabolism
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2021.12.012
State	Published - Jan 4 2022

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2021.12.012

Cite this

@article{d09d13b9bf8242d3983c8e5a039d154f,

title = "Why does obesity cause diabetes?",

abstract = "The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.",

author = "Samuel Klein and Amalia Gastaldelli and Hannele Yki-J{\"a}rvinen and Scherer, {Philipp E.}",

note = "Funding Information: The study was supported by National Institutes of Health grants DK56341 ( Nutrition Obesity Research Center ), DK20579 ( Diabetes Research Center ), UL1TR002345 ( Clinical and Translational Science Award ), RC2-DK118620 , R01-DK55758 and R01-DK099110 , the Academy of Finland , and support from Merck , Novo Nordisk , and the Sigrid Jus{\'e}lius Foundation . Funding Information: The study was supported by National Institutes of Health grants DK56341 (Nutrition Obesity Research Center), DK20579 (Diabetes Research Center), UL1TR002345 (Clinical and Translational Science Award), RC2-DK118620, R01-DK55758 and R01-DK099110, the Academy of Finland, and support from Merck, Novo Nordisk, and the Sigrid Jus?lius Foundation. S.K. serves as a scientific consultant for Janssen and Altimmune and has a sponsored research agreement with Janssen. A.G. serves as a scientific consultant for Eli Lilly, Gilead, Inventiva, and Boehringer. H.Y.-J. serves as a scientific consultant for Merck, Novo Nordisk, Eli Lilly, and Hamni Pharmaceuticals. P.E.S. has sponsored research agreements with Merck and Novo Nordisk. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = jan,

day = "4",

doi = "10.1016/j.cmet.2021.12.012",

language = "English (US)",

volume = "34",

pages = "11--20",

journal = "Cell Metabolism",

issn = "1550-4131",