TY - JOUR
T1 - White matter hyperintensity burden on magnetic resonance imaging in essential tremor
AU - Oliveira, Andre P.
AU - Brickman, Adam M.
AU - Provenzano, Frank A.
AU - Muraskin, Jordan
AU - Louis, Elan D.
N1 - Funding Information:
* To whom correspondence should be addressed. E-mail: EDL2@columbia.edu Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: April 20, 2011 Accepted: May 24, 2011 Published: January 26, 2012 Copyright: ’ 2012 Oliveira et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: Adam M. Brickman was supported by K23AG029949 and 1R01AG034189 from the National Institutes of Health (Bethesda, MD). Elan D. Louis was funded by R01 NS039422, R01 NS042859, and 5P01AG007232 from the National Institutes of Health (Bethesda, MD). Competing Interests: None of the authors report any conflicts of interest.
Publisher Copyright:
© 2012 Oliveira et al.
PY - 2012
Y1 - 2012
N2 - Background: Whereas structural abnormalities in the cerebellum have been associated with essential tremor (ET), the contribution of vascular disease via white matter hyperintensities (WMHs) and strokes has not been examined. In this study, we have explored these potential associations and hypothesized that ET would be associated with greater overall WMH volume, greater cerebellar WMH volume, and greater infarct presence. Methods: In a cross-sectional magnetic resonance imaging (MRI) study of 540 community-dwelling elderly persons in northern Manhattan, New York, brain measures of total WMH volume and regional WMH volume were derived from T2-weighted fluid attenuated inverse recovery-weighted MR images. The presence of cerebral infarcts on MRI was determined as well. Results: Total WMH volume was greater among 33 ET cases than 507 controls in both univariate (OR51.41, p50.038) and fully adjusted analyses (OR51.44, p50.03). Cerebellar WMH volume was associated with marginally increased odds of ET in a univariate model (OR51.52, p50.11) and significantly increased odds in a fully adjusted multivariate model (OR51.74, p50.049). Temporal lobe WMH volume was associated with significantly increased odds of ET in both univariate (OR53.36, p,0.001) and fully adjusted models (OR53.73, p,0.001). Large strokes were significantly more common in cases than in controls in unadjusted analyses (OR53.04, p50.02) and marginally in adjusted analyses (OR52.56–2.57, p50.045–0.056). The distribution of strokes did not differ by diagnosis. Discussion: MRI data in this study indicated that ET was associated with greater total WMH volume, greater cerebellar WMH volume and possibly more strokes. Cerebrovascular disease could play a role in the development of ET.
AB - Background: Whereas structural abnormalities in the cerebellum have been associated with essential tremor (ET), the contribution of vascular disease via white matter hyperintensities (WMHs) and strokes has not been examined. In this study, we have explored these potential associations and hypothesized that ET would be associated with greater overall WMH volume, greater cerebellar WMH volume, and greater infarct presence. Methods: In a cross-sectional magnetic resonance imaging (MRI) study of 540 community-dwelling elderly persons in northern Manhattan, New York, brain measures of total WMH volume and regional WMH volume were derived from T2-weighted fluid attenuated inverse recovery-weighted MR images. The presence of cerebral infarcts on MRI was determined as well. Results: Total WMH volume was greater among 33 ET cases than 507 controls in both univariate (OR51.41, p50.038) and fully adjusted analyses (OR51.44, p50.03). Cerebellar WMH volume was associated with marginally increased odds of ET in a univariate model (OR51.52, p50.11) and significantly increased odds in a fully adjusted multivariate model (OR51.74, p50.049). Temporal lobe WMH volume was associated with significantly increased odds of ET in both univariate (OR53.36, p,0.001) and fully adjusted models (OR53.73, p,0.001). Large strokes were significantly more common in cases than in controls in unadjusted analyses (OR53.04, p50.02) and marginally in adjusted analyses (OR52.56–2.57, p50.045–0.056). The distribution of strokes did not differ by diagnosis. Discussion: MRI data in this study indicated that ET was associated with greater total WMH volume, greater cerebellar WMH volume and possibly more strokes. Cerebrovascular disease could play a role in the development of ET.
KW - Cerebellum
KW - Essential tremor
KW - Magnetic resonance imaging
KW - Stroke
KW - White matter hyperintensities
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U2 - 10.5334/TOHM.82
DO - 10.5334/TOHM.82
M3 - Article
AN - SCOPUS:84925936537
SN - 2160-8288
VL - 2
JO - Tremor and Other Hyperkinetic Movements
JF - Tremor and Other Hyperkinetic Movements
ER -