TY - JOUR
T1 - Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging
AU - DeCarolis, Nathan A.
AU - Wharton, Keith A.
AU - Eisch, Amelia J.
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by β-catentin. Emerging evidence suggests that canonical Wnt signaling influences cellular aging, indicating that increases in Wnt signaling delay age-related deficits.(1) However, recent Science papers suggest that Wnt signaling accelerates the onset of aging.(2,3) In an attempt to resolve this paradox and clarify how Wnt signaling affects aging, we provide a selective review of research relevant to Wnt signaling and aging.
AB - Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by β-catentin. Emerging evidence suggests that canonical Wnt signaling influences cellular aging, indicating that increases in Wnt signaling delay age-related deficits.(1) However, recent Science papers suggest that Wnt signaling accelerates the onset of aging.(2,3) In an attempt to resolve this paradox and clarify how Wnt signaling affects aging, we provide a selective review of research relevant to Wnt signaling and aging.
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U2 - 10.1002/bies.20709
DO - 10.1002/bies.20709
M3 - Review article
C2 - 18200563
AN - SCOPUS:38849092190
SN - 0265-9247
VL - 30
SP - 102
EP - 106
JO - BioEssays
JF - BioEssays
IS - 2
ER -