When evidence is lacking: A mixed-methods approach for the development of practice guidance in liver transplantation

Lisa B. Vanwagner; Blessing Aghaulor; Tasmeen Hussain; Megan Kosirog; Patrick Campbell; Stewart Pine; Amna Daud; Daniel J. Finn; Josh Levitsky; Donald M. Lloyd-Jones; Jane L. Holl

doi:10.1093/gastro/goaa068

When evidence is lacking: A mixed-methods approach for the development of practice guidance in liver transplantation

Lisa B. Vanwagner, Blessing Aghaulor, Tasmeen Hussain, Megan Kosirog, Patrick Campbell, Stewart Pine, Amna Daud, Daniel J. Finn, Josh Levitsky, Donald M. Lloyd-Jones, Jane L. Holl

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Most interventions for conditions with a small cohort size, such as transplantation, are unlikely to be part of a clinical trial. When condition-specific evidence is lacking, expert consensus can offer more precise guidance to improve care. Management of cardiovascular risk in liver-transplant recipients is one example for which clinicians have, to date, adapted evidence-based guidelines from studies in the general population. However, even when consensus is achieved, implementation of practice guidance is often inadequate and protracted. We report on a novel mixed-methods approach, the Northwestern Method.

Original language	English (US)
Pages (from-to)	22-30
Number of pages	9
Journal	Gastroenterology Report
Volume	9
Issue number	1
DOIs	https://doi.org/10.1093/gastro/goaa068
State	Published - Jan 1 2021
Externally published	Yes

Keywords

consensus
liver transplantation
methodology
practice guideline

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.1093/gastro/goaa068

Cite this

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abstract = "Background: Most interventions for conditions with a small cohort size, such as transplantation, are unlikely to be part of a clinical trial. When condition-specific evidence is lacking, expert consensus can offer more precise guidance to improve care. Management of cardiovascular risk in liver-transplant recipients is one example for which clinicians have, to date, adapted evidence-based guidelines from studies in the general population. However, even when consensus is achieved, implementation of practice guidance is often inadequate and protracted. We report on a novel mixed-methods approach, the Northwestern Method.",

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AU - Campbell, Patrick

AU - Pine, Stewart

AU - Daud, Amna

AU - Finn, Daniel J.

AU - Levitsky, Josh

AU - Lloyd-Jones, Donald M.

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When evidence is lacking: A mixed-methods approach for the development of practice guidance in liver transplantation

Abstract

Keywords

ASJC Scopus subject areas

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