TY - JOUR
T1 - What is the appropriate intravenous dose of vitamin E for very-low-birth-weight infants?
AU - Brion, Luc P.
AU - Bell, Edward F.
AU - Raghuveer, Talkad S.
AU - Soghier, Lamia
PY - 2004/4
Y1 - 2004/4
N2 - The Committee on Fetus and Newborn of the American Academy of Pediatrics (AAP) has endorsed 1 to 2 mg/dl as the normal range of serum tocopherol level. Our Cochrane review has shown that vitamin E supplementation resulting in levels >3.5 mg/dl, but not ≤3.5 mg/dl, significantly reduces the risk for severe retinopathy among very-low-birth-weight (VLBW) infants examined but increases the risks of sepsis and of necrotizing enterocolitis among infants treated for >1 week. As a fixed daily intravenous dose of vitamin E results in an inverse relationship between serum level and birth weight and is a risk for both low and high serum tocopherol levels, a dose adjusted for current weight appears more judicious than a fixed dose per day. Based on currently available data the AAP and the American Society for Clinical Nutrition currently recommend a routine intake of 2 ml/kg/day of MVI® Pediatric™ (2.8 IU/kg/day) in VLBW infants (maximum of 5 ml/day or 7 IU/day).
AB - The Committee on Fetus and Newborn of the American Academy of Pediatrics (AAP) has endorsed 1 to 2 mg/dl as the normal range of serum tocopherol level. Our Cochrane review has shown that vitamin E supplementation resulting in levels >3.5 mg/dl, but not ≤3.5 mg/dl, significantly reduces the risk for severe retinopathy among very-low-birth-weight (VLBW) infants examined but increases the risks of sepsis and of necrotizing enterocolitis among infants treated for >1 week. As a fixed daily intravenous dose of vitamin E results in an inverse relationship between serum level and birth weight and is a risk for both low and high serum tocopherol levels, a dose adjusted for current weight appears more judicious than a fixed dose per day. Based on currently available data the AAP and the American Society for Clinical Nutrition currently recommend a routine intake of 2 ml/kg/day of MVI® Pediatric™ (2.8 IU/kg/day) in VLBW infants (maximum of 5 ml/day or 7 IU/day).
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U2 - 10.1038/sj.jp.7211078
DO - 10.1038/sj.jp.7211078
M3 - Article
C2 - 15067295
AN - SCOPUS:14044261696
SN - 0743-8346
VL - 24
SP - 205
EP - 207
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -