TY - JOUR
T1 - What a dinner party! mechanisms and functions of interkingdom signaling in host-pathogen associations
AU - Kendall, Melissa M.
AU - Sperandio, Vanessa
N1 - Funding Information:
We apologize to the numerous investigators whose work could not be cited because of space constraints.Work in V.S.’s laboratory is supported by National Institutes of Health grants AI053067, AI077613, AI05135, and AI114511. Work in M.K.’s laboratory is supported by National Institutes of Health grant AI118732. The contents of this review are solely the responsibility of the authors and do not represent the official views of the NIAID, NIH.This work, including the efforts of Vanessa Sperandio, was funded by HHS|NIH| National Institute of Allergy and Infectious Diseases (NIAID) (AI053067, AI077613, AI105135, and AI114511). This work, including the efforts of Melissa M. Kendall, was funded by HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) (AI118732).
Publisher Copyright:
© 2016 Kendall and Sperandio.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Chemical signaling between cells is an effective way to coordinate behavior within a community. Although cell-tocell signaling has mostly been studied in single species, it is now appreciated that the sensing of chemical signals across kingdoms can be an important regulator of nutrient acquisition, virulence, and host defense. In this review, we focus on the role of interkingdom signaling in the interactions that occur between bacterial pathogens and their mammalian hosts. We discuss the quorum-sensing (QS) systems and other mechanisms used by these bacteria to sense, respond to, and modulate host signals that include hormones, immune factors, and nutrients. We also describe cross talk between these signaling pathways and strategies used by the host to interfere with bacterial signaling, highlighting the complex bidirectional signaling networks that are established across kingdoms.
AB - Chemical signaling between cells is an effective way to coordinate behavior within a community. Although cell-tocell signaling has mostly been studied in single species, it is now appreciated that the sensing of chemical signals across kingdoms can be an important regulator of nutrient acquisition, virulence, and host defense. In this review, we focus on the role of interkingdom signaling in the interactions that occur between bacterial pathogens and their mammalian hosts. We discuss the quorum-sensing (QS) systems and other mechanisms used by these bacteria to sense, respond to, and modulate host signals that include hormones, immune factors, and nutrients. We also describe cross talk between these signaling pathways and strategies used by the host to interfere with bacterial signaling, highlighting the complex bidirectional signaling networks that are established across kingdoms.
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U2 - 10.1128/mBio.01748-15
DO - 10.1128/mBio.01748-15
M3 - Review article
C2 - 26933054
AN - SCOPUS:84965114257
SN - 2161-2129
VL - 7
JO - mBio
JF - mBio
IS - 2
M1 - e01748-15
ER -