Homeostatic regulation of bile acid metabolism and biliary lipid secretion is critical to prevent enterohepatic diseases. Kaestner and coworkers (Bochkis et al., 2008) show that loss of forkhead box transcription factor Foxa2 in the liver leads to hepatic injury due to downregulation in the expression levels of bile acid transporters and detoxification enzymes.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Oct 8 2008|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology