TY - JOUR
T1 - Weight loss reduces dyspnea on exertion and unpleasantness of dyspnea in obese men
AU - Bernhardt, Vipa
AU - Bhammar, Dharini M.
AU - Marines-Price, Rubria
AU - Babb, Tony G.
N1 - Funding Information:
The authors wish to thank Dr. Jonathon Stickford, J. Todd Bassett, Joseph Genovese, Andreas Kreutzer, Anastasia Pyz, Maria Roman, and Deborah Trevino for their assistance in various stages of this project, and the staff members of the Texas Health Finley Ewing Cardiovascular & Fitness Center Dallas for their expertise in implementing the diet and exercise program, especially Gerry Maness and Susan Rodder. This work was supported by the National Institutes of Health (HL096782), King Charitable Foundation Trust , Cain Foundation , and Texas Health Presbyterian Hospital Dallas . The funding sources had no involvement in the study design; collection, analysis and interpretation of data; writing of the report; nor decision to submit the article for publication.
Publisher Copyright:
© 2019
PY - 2019/3
Y1 - 2019/3
N2 - We hypothesized that weight loss would ameliorate dyspnea on exertion (DOE) and feelings of unpleasantness related to the DOE in obese men. Eighteen men (34 ± 7yr, 35 ± 4 kg/m 2 BMI, mean ± SD) participated in a 12-week weight loss program. Body composition, pulmonary function, cardiorespiratory measures, DOE, and unpleasantness (visual analog scale) were assessed before and after weight loss. Subjects were grouped by Ratings of Perceived Breathlessness (RPB, Borg 0–10 scale) during submaximal cycling: Ten men rated RPB ≥ 4 (+DOE), eight rated RPB ≤ 2 (–DOE). Subjects lost 10.3 ± 5.6 kg (9.2 ± 4.5%) of body weight (n = 18). RPB during submaximal cycling was significantly improved in both groups (+DOE: 4.1 ± 0.3–2.8 ± 1.1; –DOE: 1.3 ± 0.7 to 0.8 ± 0.6, p < 0.001). Several submaximal exercise variables (e.g., V˙O 2 , V˙ E ) were decreased similarly in both groups (p < 0.01). Unpleasantness associated with the DOE was reduced (p < 0.05). The improved RPB was not significantly correlated with changes in body weight or cardiopulmonary exercise responses (p > 0.05). Moderate weight loss appears to be an effective option to ameliorate DOE and unpleasantness related to DOE in obese men.
AB - We hypothesized that weight loss would ameliorate dyspnea on exertion (DOE) and feelings of unpleasantness related to the DOE in obese men. Eighteen men (34 ± 7yr, 35 ± 4 kg/m 2 BMI, mean ± SD) participated in a 12-week weight loss program. Body composition, pulmonary function, cardiorespiratory measures, DOE, and unpleasantness (visual analog scale) were assessed before and after weight loss. Subjects were grouped by Ratings of Perceived Breathlessness (RPB, Borg 0–10 scale) during submaximal cycling: Ten men rated RPB ≥ 4 (+DOE), eight rated RPB ≤ 2 (–DOE). Subjects lost 10.3 ± 5.6 kg (9.2 ± 4.5%) of body weight (n = 18). RPB during submaximal cycling was significantly improved in both groups (+DOE: 4.1 ± 0.3–2.8 ± 1.1; –DOE: 1.3 ± 0.7 to 0.8 ± 0.6, p < 0.001). Several submaximal exercise variables (e.g., V˙O 2 , V˙ E ) were decreased similarly in both groups (p < 0.01). Unpleasantness associated with the DOE was reduced (p < 0.05). The improved RPB was not significantly correlated with changes in body weight or cardiopulmonary exercise responses (p > 0.05). Moderate weight loss appears to be an effective option to ameliorate DOE and unpleasantness related to DOE in obese men.
KW - Breathlessness
KW - Exercise
KW - Negative emotions
KW - Obesity
KW - Respiratory perception
KW - Sensory perception
KW - Shortness of breath
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U2 - 10.1016/j.resp.2019.01.007
DO - 10.1016/j.resp.2019.01.007
M3 - Article
C2 - 30658095
AN - SCOPUS:85060247772
SN - 1569-9048
VL - 261
SP - 55
EP - 61
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
ER -