Volumetric fat-water separated T2-weighted MRI

Shreyas S. Vasanawala, Ananth J. Madhuranthakam, Ramesh Venkatesan, Arvind Sonik, Peng Lai, Anja C S Brau

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Pediatric body MRI exams often cover multiple body parts, making the development of broadly applicable protocols and obtaining uniform fat suppression a challenge. Volumetric T2 imaging with Dixon-type fat-water separation might address this challenge, but it is a lengthy process. Objective: We develop and evaluate a faster two-echo approach to volumetric T2 imaging with fat-water separation. Materials and methods: A volumetric spin-echo sequence was modified to include a second shifted echo so two image sets are acquired. A region-growing reconstruction approach was developed to decompose separate water and fat images. Twenty-six children were recruited with IRB approval and informed consent. Fat-suppression quality was graded by two pediatric radiologists and compared against conventional fat-suppressed fast spin-echo T2-W images. Additionally, the value of in- and opposed-phase images was evaluated. Results: Fat suppression on volumetric images had high quality in 96% of cases (95% confidence interval of 80-100%) and were preferred over or considered equivalent to conventional two-dimensional fat-suppressed FSE T2 imaging in 96% of cases (95% confidence interval of 78-100%). In- and opposed-phase images had definite value in 12% of cases. Conclusion: Volumetric fat-water separated T2-weighted MRI is feasible and is likely to yield improved fat suppression over conventional fat-suppressed T2-weighted imaging.

Original languageEnglish (US)
Pages (from-to)875-883
Number of pages9
JournalPediatric radiology
Issue number7
StatePublished - Jul 2011


  • Fat suppression
  • MRI
  • Pediatric
  • T2

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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