Viscous optical clearing agent for in vivo optical imaging

Zijian Deng, Lijia Jing, Ning Wu, Pengyu Lv, Xiaoyun Jiang, Qiushi Ren, Changhui Li

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


By allowing more photons to reach deeper tissue, the optical clearing agent (OCA) has gained increasing attention in various optical imaging modalities. However, commonly used OCAs have high fluidity, limiting their applications in in vivo studies with oblique, uneven, or moving surfaces. In this work, we reported an OCA with high viscosity. We measured the properties of this viscous OCA, and tested its successful performances in the imaging of a living animal's skin with two optical imaging modalities: photoacoustic microscopy and optical coherence tomography. Our results demonstrated that the viscous OCA has a great potential in the study of different turbid tissues using various optical imaging modalities.

Original languageEnglish (US)
Article number076019
JournalJournal of biomedical optics
Issue number7
StatePublished - Jul 2014
Externally publishedYes


  • optical clearing
  • optical coherent tomography
  • optical imaging
  • photoacoustic microscopy
  • ultrasonic coupling

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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