Virilization persists in a woman with an androgen-secreting granulosa cell tumor

Objective: To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization. Design: Case report. Setting: University medical center. Patient(s): A 45-year-old woman with abrupt onset of virilization with high serum androgen levels. Intervention(s): Exploratory laparotomy with full staging. Main Outcome Measure(s): Surgical findings and histopathologic observations are included in this report. Result(s): Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery. Conclusion(s): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.