Versatile type III effector mechanisms can disrupt target-cell functions

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


• By injecting proteins called effectors into host cells, bacterial pathogens can alter crucial biochemical signaling pathways in those targeted cells. • The effectors from different bacteria may do very different things in host cells, mimicking or usurping eukaryotic activities in a variety of ways. • Bacteria apparently reshuffled the domains of some eukaryotic genes to produce novel virulence factors. • Instead of hydrolyzing target proteins in host cells, the bacterial effector YopJ modifies proteins by acetylating serine and threonine residues on the activation loop of certain kinases.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
Issue number4
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Microbiology


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