Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption

Erica C. Henning; Lawrence L. Latour; Steven Warach

doi:10.1038/sj.jcbfm.9600598

Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption

Erica C. Henning, Lawrence L. Latour, Steven Warach

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.

Original language	English (US)
Pages (from-to)	882-886
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	28
Issue number	5
DOIs	https://doi.org/10.1038/sj.jcbfm.9600598
State	Published - May 2008

Keywords

ADC
Blood-brain barrier
CSF
FLAIR
HARM
Stroke

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/sj.jcbfm.9600598

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abstract = "Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.",

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Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption

Abstract

Keywords

ASJC Scopus subject areas

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