Variation in hospital risk-adjusted mortality rates following transcatheter aortic valve replacement in the United States

Sean M. O'Brien, David J. Cohen, John S. Rumsfeld, J. Matthew Brennan, David M. Shahian, David Dai, David R. Holmes, Rosemarie B. Hakim, Vinod H. Thourani, Eric D. Peterson, Fred H. Edwards

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background - The use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis in the United States is growing, yet little is known about the variation in procedural outcomes in community practice. We developed a TAVR in-hospital mortality risk model and used it to quantify variation in mortality rates across United States (US) TAVR centers. Methods and Results - We analyzed data from 22 248 TAVR procedures performed at 318 sites participating in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry (November 2011 to October 2014). A Bayesian hierarchical model was developed to estimate hospital-specific risk-adjusted mortality rates adjusting for 40 patient baseline factors. A total of 1130 in-hospital deaths (5.1%) were observed. Reliability-adjusted risk-adjusted mortality rate estimates ranged from 3.4% to 7.7% with an interquartile range of 4.8% to 5.4%. A patient's predicted odds of dying was 80% higher if treated by a hospital 1 standard deviation above the mean compared with a hospital 1 standard deviation below the mean (odds ratio =1.8; 95% credible interval, 1.4%-2.2%). Conclusions - Risk modeling of TAVR in-hospital mortality revealed variation in risk-adjusted mortality rates during the US early commercial experience. Transcatheter Valve Therapy Registry analyses using this model will support research, feedback reporting, and the identification of factors associated with quality.

Original languageEnglish (US)
Pages (from-to)560-565
Number of pages6
JournalCirculation: Cardiovascular Quality and Outcomes
Issue number5
StatePublished - Sep 1 2016
Externally publishedYes


  • aortic stenosis
  • case-mix adjustment
  • outcomes analysis
  • outcomes research
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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