@article{da1a538914d14494ab3b5451a919200f,
title = "Validation of a physician global assessment tool for vitiligo extent: Results of an international vitiligo expert meeting",
abstract = "Currently, vitiligo lacks a validated Physician Global Assessment (PGA) for disease extent. This PGA can be used to stratify and interpret the numeric scores obtained by the Vitiligo Extent Score (VES). We investigated the interrater reliability of a 5-point PGA scale during an international vitiligo workshop. Vitiligo experts from five different continents rated photographs of non-segmental vitiligo patients with varying degrees of extent with the PGA score. Good interrater agreements (intraclass correlation coefficient >0.6) were observed between the raters overall and within each continent. All hypotheses to evaluate construct validity were confirmed. Median VES values per category were for limited 1.10 [IQR: 0.21–1.67], moderate 3.17 [IQR: 1.75–6.21], extensive 9.58 [IQR: 6.21–13.03] and very extensive 42.67 [IQR: 21.20–42.67]. Defined categories for vitiligo extent can be valuable for inclusion criteria and may impact future reimbursement criteria.",
keywords = "body surface area, extent, global assessment, outcome measure, severity, vitiligo",
author = "{the participants of the Rome International VGICC /VIS Workshop} and {van Geel}, Nanja and Albert Wolkerstorfer and Khaled Ezzedine and Pandya, {Amit G.} and Marcel Bekkenk and Lynda Grine and {Van Belle}, Sarah and Lommerts, {Janny E.} and Iltefat Hamzavi and Harris, {John E.} and Viktoria Eleftheriadou and Samia Esmat and Kang, {Hee Young} and Prasad Kumarasinghe and Lan, {Cheng Che E.} and Davinder Parsad and Noufal Raboobee and {Flora Xiang}, Leihong and Tamio Suzuki and Prinsen, {Cecilia A.} and Alain Taieb and Mauro Picardo and Reinhart Speeckaert and Tag Anbar and Mohamed Anbar and La{\"i}la Benzekri and Markus B{\"o}hm and Ca{\"i}o Castro and Tania Cestari and Yvon Gauthier and Maria Gnarra and Jorge Hinojosa and Jung, {Min Bae} and Ichiro Katayama and Kim, {Ki Ho} and {Eric Lan}, {Cheng Che} and Lee, {Seung Chung} and {Le Poole}, Caroline and Henry Lim and Silvia Moretti and Julien Seneschal and Richard Spritz and {van Geel}, Nanja and Flora Xiang",
note = "Funding Information: We thank all participants of the VGICC workshop, with a very special word of gratitude to our dear friend Tag Anbar (in memoriam). We would like to express our gratitude to the volunteering patients for the use of their pictures during the workshop. We acknowledge the Vitiligo International Symposium (VIS) and the Vitiligo Global Issues Consensus Conference (VIGCC) groups as a supporting organizing source of the workshop. Funding sources related to the workshop and/or analyses afterwards: EADV grant (EADV Project proposal reference number 2015-030) and LEO Foundation grant (Leo Foundation project reference number LF16092). The research activities of N. van Geel are supported by the Scientific Research Foundation-Flanders (FWO Senior Clinical Investigator: 1831512N). We would like to thank I. Sperduti for local (Italy) statistical support and T. Mostien for assistance in processing of data. Funding Information: We thank all participants of the VGICC workshop, with a very spe‐ cial word of gratitude to our dear friend Tag Anbar (in memoriam). We would like to express our gratitude to the volunteering patients for the use of their pictures during the workshop. We acknowledge the Vitiligo International Symposium (VIS) and the Vitiligo Global Issues Consensus Conference (VIGCC) groups as a supporting or‐ ganizing source of the workshop. Funding sources related to the workshop and/or analyses afterwards: EADV grant (EADV Project proposal reference number 2015‐030) and LEO Foundation grant (Leo Foundation project reference number LF16092). The research activities of N. van Geel are supported by the Scientific Research Foundation‐Flanders (FWO Senior Clinical Investigator: 1831512N). Funding Information: Scientific Research Foundation‐Flanders (FWO Senior Clinical Investigator), Grant/ Award Number: 1831512N; Leo Foundation grant, Grant/Award Number: LF16092; EADV grant (EADV Project proposal), Grant/Award Number: 2015‐030 Funding Information: Nanja van Geel : consultant and/or investigator in Pfizer, Laboratoire G{\'e}n{\'e}vrier, Incyte. Drs van Geel, Speeckaert, Wolkerstorfer, Bekkenk, Lommerts and Prinsen were involved to a certain extent in the preparative stage of the PGA score used. Albert Wolkerstorfer was consultant in Incyte, is investigator in Novartis, and received a research grant from AvitaMedical. Iltefat Hamzavi was a consultant in Incyte and received fees; an investigator in Bayer (grant paid to institution); an investigator in Johnson and Johnson (provided equip‐ ment to institution); an investigator in Incyte, Estee Lauder, Unigen Inc, Allergan and Ferndale Laboratories (grant paid to institution); a consultant in Pfizer and received fees; and co‐chair in Global Vitiligo Foundation and played a non‐compensated role. Amit G. Pandya was a consultant in Sun pharmaceuticals and TWi pharmaceuticals; an investigator for Aclaris pharmaceuticals, Incyte pharmaceuticals and Pfizer pharmaceuticals; and was the board of directors and owned stock options with Clarify Medical. Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2019",
doi = "10.1111/pcmr.12784",
language = "English (US)",
volume = "32",
pages = "728--733",
journal = "Pigment Cell and Melanoma Research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",
number = "5",
}