TY - JOUR
T1 - UTSW small animal positron emission imager
AU - Tsyganov, Edward N.
AU - Anderson, Jon
AU - Arbique, Gary
AU - Constantinescu, Anca
AU - Jennewein, Marc
AU - Kulkarni, Padmakar V.
AU - Mason, Ralph P.
AU - McColl, Roderick W.
AU - Öz, Orhan K.
AU - Parkey, Robert W.
AU - Richer, Edmond
AU - Rösch, Frank
AU - Seliounine, Serguei Y.
AU - Slavine, Nikolai V.
AU - Srivastava, Suresh C.
AU - Thorpe, Philip E.
AU - Zinchenko, Alexander I.
AU - Antich, Peter P.
N1 - Funding Information:
Manuscript received February 11, 2006; revised April 23, 2006. This work was supported by unrestricted funds from the Effie and Woffard Cain Distinguished Chair in Diagnostic Imaging (RWP), the Cancer Imaging Program (an NCI Pre-ICMIC) 1P 20, Grant CRDF 34-13551, and DoD Grant W81XWH0410551.
PY - 2006/10
Y1 - 2006/10
N2 - A Small Animal Imager (SAI) for PET has been designed, built, tested in phantoms, and applied to investigations in mice and rats. The device uses principles based on γ-ray induced scintillation in crossed fiber optic detectors connected to Position Sensitive Photomultiplier Tubes (PSPMT). Each detector consists of an epoxied stack of 28 layers of 135 round 1 mm BCF-10 scintillating plastic fibers. The overlap region forms a 13.5 × 13.5 × 2.8 cm 3 detector volume. Scintillating light from the fibers is detected by two (X and Y directions) Hamamatsu R-2486 PSPMTs with 16 anode wires in each of two orthogonal directions. A centroid-finding algorithm gives the position of a light cluster on the face (photocathode) of a PSPMT. The accuracy of the reconstruction of an interaction position is essentially independent of light cluster position. This translates to a nearly Isotropic photon response for the entire detector. The system has been used to test several 3D image reconstruction algorithms, software modifications, and improvements. The sensitivity (∼12.6 cps/kBq at 9 cm inner diameter) and sub-millimeter spatial resolution (better than 1 mm in phantoms) obtained with an iterative algorithm incorporating system modeling make the SAI a relatively inexpensive high performance animal imager. The SAI is currently being used for imaging experiments in mice and rats.
AB - A Small Animal Imager (SAI) for PET has been designed, built, tested in phantoms, and applied to investigations in mice and rats. The device uses principles based on γ-ray induced scintillation in crossed fiber optic detectors connected to Position Sensitive Photomultiplier Tubes (PSPMT). Each detector consists of an epoxied stack of 28 layers of 135 round 1 mm BCF-10 scintillating plastic fibers. The overlap region forms a 13.5 × 13.5 × 2.8 cm 3 detector volume. Scintillating light from the fibers is detected by two (X and Y directions) Hamamatsu R-2486 PSPMTs with 16 anode wires in each of two orthogonal directions. A centroid-finding algorithm gives the position of a light cluster on the face (photocathode) of a PSPMT. The accuracy of the reconstruction of an interaction position is essentially independent of light cluster position. This translates to a nearly Isotropic photon response for the entire detector. The system has been used to test several 3D image reconstruction algorithms, software modifications, and improvements. The sensitivity (∼12.6 cps/kBq at 9 cm inner diameter) and sub-millimeter spatial resolution (better than 1 mm in phantoms) obtained with an iterative algorithm incorporating system modeling make the SAI a relatively inexpensive high performance animal imager. The SAI is currently being used for imaging experiments in mice and rats.
KW - Antibodies
KW - Arsenic
KW - FDG
KW - Image reconstruction
KW - Positron emission tomography
KW - Small animal imaging
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U2 - 10.1109/TNS.2006.876000
DO - 10.1109/TNS.2006.876000
M3 - Article
AN - SCOPUS:33750402229
SN - 0018-9499
VL - 53
SP - 2591
EP - 2599
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
IS - 5
M1 - 1710243
ER -