Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia

on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group

doi:10.1038/s41372-019-0508-5

Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia

on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.

Original language	English (US)
Pages (from-to)	149-156
Number of pages	8
Journal	Journal of Perinatology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1038/s41372-019-0508-5
State	Published - Jan 1 2020

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-019-0508-5

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@article{b3046c10c6b84fb0ac1d6cb87c93b4ab,

title = "Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia",

abstract = "Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children{\textquoteright}s Hospitals Neonatal Database who had echocardiograms 34–44 weeks{\textquoteright} postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.",

author = "{on behalf of the Children{\textquoteright}s Hospitals Neonatal Consortium Severe BPD Focus Group} and Shilpa Vyas-Read and Wymore, {Erica M.} and Isabella Zaniletti and Karna Murthy and Padula, {Michael A.} and Truog, {William E.} and Engle, {William A.} and Savani, {Rashmin C.} and Sushmita Yallapragada and Logan, {J. Wells} and Huayan Zhang and Hysinger, {Erik B.} and Grover, {Theresa R.} and Girija Natarajan and Nelin, {Leif D.} and Porta, {Nicolas F.M.} and Potoka, {Karin P.} and Robert DiGeronimo and Lagatta, {Joanne M.}",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2020",

month = jan,

day = "1",

doi = "10.1038/s41372-019-0508-5",

language = "English (US)",

volume = "40",

pages = "149--156",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia

AU - on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group

AU - Vyas-Read, Shilpa

AU - Wymore, Erica M.

AU - Zaniletti, Isabella

AU - Murthy, Karna

AU - Padula, Michael A.

AU - Truog, William E.

AU - Engle, William A.

AU - Savani, Rashmin C.

AU - Yallapragada, Sushmita

AU - Logan, J. Wells

AU - Zhang, Huayan

AU - Hysinger, Erik B.

AU - Grover, Theresa R.

AU - Natarajan, Girija

AU - Nelin, Leif D.

AU - Porta, Nicolas F.M.

AU - Potoka, Karin P.

AU - DiGeronimo, Robert

AU - Lagatta, Joanne M.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.

AB - Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.

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U2 - 10.1038/s41372-019-0508-5

DO - 10.1038/s41372-019-0508-5

M3 - Article

C2 - 31570799

AN - SCOPUS:85074329638

SN - 0743-8346

VL - 40

SP - 149

EP - 156

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 1

ER -

Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia

Abstract

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