Abstract
Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1398-1405 |
| Number of pages | 8 |
| Journal | Journal of Perinatology |
| Volume | 43 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2023 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
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In: Journal of Perinatology, Vol. 43, No. 11, 11.2023, p. 1398-1405.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Use of term reference infants in assessing the developmental outcome of extremely preterm infants
T2 - lessons learned in a multicenter study
AU - Green, Charles E.
AU - Tyson, Jon E.
AU - Heyne, Roy J.
AU - Hintz, Susan R.
AU - Vohr, Betty R.
AU - Bann, Carla M.
AU - Das, Abhik
AU - Bell, Edward F.
AU - Debsareea, Sana Boral
AU - Stephens, Emily
AU - Gantz, Marie G.
AU - Petrie Huitema, Carolyn M.
AU - Johnson, Karen J.
AU - Watterberg, Kristi L.
AU - Mosquera, Ricardo
AU - Peralta-Carcelen, Myriam
AU - Wilson-Costello, Deanne E.
AU - Colaizy, Tarah T.
AU - Maitre, Nathalie L.
AU - Merhar, Stephanie L.
AU - Adams-Chapman, Ira
AU - Fuller, Janell
AU - Hartley-McAndrew, Michelle E.
AU - Malcolm, William F.
AU - Winter, Sarah
AU - Duncan, Andrea F.
AU - Myer, Gary J.
AU - Kicklighter, Stephen D.
AU - Wyckoff, Myra H.
AU - DeMauro, Sara B.
AU - Hibbs, Anna Maria
AU - Stoll, Barbara J.
AU - Carlo, Waldemar A.
AU - Van Meurs, Krisa P.
AU - Rysavy, Matthew A.
AU - Patel, Ravi M.
AU - Sánchez, Pablo J.
AU - Laptook, Abbot R.
AU - Cotten, C. Michael
AU - D’Angio, Carl T.
AU - Walsh, Michele C.
AU - Polin, Richard A.
AU - Keszler, Martin
AU - Hensman, Angelita M.
AU - Vieira, Elisa
AU - Pierre, Lucille St
AU - Burke, Robert T.
AU - Alksninis, Barbara
AU - Knoll, Andrea
AU - Keszler, Mary L.
AU - Leach, Teresa M.
AU - McGowan, Elisabeth C.
AU - Watson, Victoria E.
AU - Newman, Nancy S.
AU - Siner, Bonnie S.
AU - Roth, Elizabeth
AU - Williams, Angelia
AU - Poindexter, Brenda B.
AU - Schibler, Kurt
AU - Cahill, K. Tanya E.
AU - Grisby, Cathy
AU - Kirker, Kristin
AU - Stacey, Sara
AU - Wuertz, Sandra
AU - Goldberg, Ronald N.
AU - Goldstein, Ricki F.
AU - Ashley, Patricia L.
AU - Mago-Shah, Deesha
AU - Finkle, Joanne
AU - Fisher, Kimberley A.
AU - Gustafson, Kathryn E.
AU - Stone, Caitlin
AU - Laughon, Matthew M.
AU - Bernhardt, Janice
AU - Wereszczak, Janice
AU - Talbert, Jennifer
AU - Bentley, Alexandra
AU - Edwards, Laura
AU - Rhodes-Ryan, Ginger
AU - White, Donna
AU - Carlton, David P.
AU - Loggins, Yvonne
AU - Bottcher, Diane
AU - Carter, Sheena L.
AU - Kendrick-Allwood, Salathiel
AU - LaRossa, Maureen Mulligan
AU - Laursen, Judith
AU - Mackie, Colleen
AU - Sanders, Amy
AU - Smikle, Gloria
AU - Wineski, Lynn
AU - Bremer, Andrew A.
AU - Higgins, Rosemary D.
AU - Archer, Stephanie Wilson
AU - Khan, Amir M.
AU - Kennedy, Kathleen A.
AU - Duncan, Andrea F.
AU - Allain, Elizabeth
AU - Arldt-McAlister, Julie
AU - Boricha, Fatima
AU - Dempsey, Allison G.
AU - Garcia, Carmen
AU - Hall, Donna J.
AU - John, Janice
AU - Lillie, M. Layne
AU - Martin, Karen
AU - McDavid, Georgia E.
AU - McKee, Shannon L.
AU - Poe, Michelle
AU - Rennie, Kimberly
AU - Reddy, Tina
AU - Rodgers, Shawna
AU - Sperry, Daniel K.
AU - Wright, Sharon L.
AU - Nelin, Leif D.
AU - Slaughter, Jonathan L.
AU - Jadcherla, Sudarshan R.
AU - Timan, Christopher
AU - Luzader, Patricia
AU - Stein, Melanie
AU - Sullivan, Rox Ann
AU - Carey, Helen
AU - Burkhardt, Stephanie
AU - Nelin, Mary Ann
AU - Clark, Erna
AU - Small, Kristi
AU - McCool, Jacqueline
AU - Pietruszewski, Lindsay
AU - Purnell, Jessica
AU - Warnimont, Kyrstin
AU - Marzec, Laura
AU - Miller, Bethany
AU - Beckford, Demi R.
AU - Baugher, Hallie
AU - Levengood, Katelyn
AU - Batterson, Nancy
AU - Tonneman, Jill
AU - Hay, Krystal
AU - DeSantis, Brittany
AU - Wallace, Dennis
AU - Auman, Jeanette O’ Donnell
AU - Crawford, Margaret
AU - Gabrio, Jenna
AU - Newman, Jamie E.
AU - Parlberg, Lindsay
AU - Zaterka-Baxter, Kristin M.
AU - Stevenson, David K.
AU - Ball, M. Bethany
AU - Chock, Valerie
AU - Bahmani, Dona
AU - Bentley, Barbara
AU - DeAnda, Maria Elena
AU - DeBattista, Anne M.
AU - Earhart, Beth
AU - Huffman, Lynne C.
AU - Krueger, Casey E.
AU - Lucash, Ryan E.
AU - Taylor, Heather
AU - Weiss, Hali E.
AU - Ambalavanan, Namasivayam
AU - Bailey, Kirstin J.
AU - Biasini, Fred J.
AU - Chopko, Stephanie A.
AU - Collins, Monica V.
AU - Cosby, Shirley S.
AU - Domnanovich, Kristy A.
AU - Jno-Finn, Chantel J.
AU - Ladinsky, Morissa
AU - Moses, Mary Beth
AU - McNair, Tara E.
AU - Phillips, Vivien A.
AU - Preskitt, Julie
AU - Rector, Richard V.
AU - Stringer, Kimberlly
AU - Whitley, Sally
AU - Chapman, Sheree York
AU - Harmon, Heidi M.
AU - Johnson, Karen J.
AU - Schmelzel, Mendi L.
AU - Walker, Jacky R.
AU - Goeke, Claire A.
AU - Faruqui, Sarah E.
AU - Eastman, Diane L.
AU - Baack, Michelle L.
AU - Hogden, Laurie A.
AU - Henning, Megan M.
AU - Elenkiwich, Chelsey
AU - Broadbent, Megan
AU - Van Muyden, Sarah
AU - Ohls, Robin K.
AU - Lacy, Conra Backstrom
AU - Beauman, Sandra Sundquist
AU - Hanson, Mary Ruffner
AU - Lowe, Jean R.
AU - Kuan, Elizabeth
AU - Eichenwald, Eric C.
AU - Schmidt, Barbara
AU - Kirpalani, Haresh
AU - Abbasi, Soraya
AU - Chaudhary, Aasma S.
AU - Mancini, Toni
AU - Snyder, Jonathan
AU - Ziolkowski, Kristina
AU - Guillet, Ronnie
AU - Lakshminrusimha, Satyan
AU - Reynolds, Anne Marie
AU - Jensen, Rosemary L.
AU - Merzbach, Joan
AU - Zorn, William
AU - Farooq, Osman
AU - Myers, Gary J.
AU - Rowan, Mary
AU - Prinzing, Diane
AU - Bowman, Melissa
AU - Scorsone, Ann Marie
AU - Binion, Kyle
AU - Orme, Constance
AU - Sabaratnam, Premini
AU - Kent, Alison
AU - Jones, Rachel
AU - Boylin, Elizabeth
AU - Li, Emily
AU - Kachelmeyer, Jennifer
AU - McKee, Kimberly G.
AU - Coleman, Kelly R.
AU - Cavanaugh, Brenna
AU - Brion, Luc P.
AU - Vasil, Diana M.
AU - Adams, Sally S.
AU - Eubanks, Frances
AU - McDougald, E. Rebecca
AU - Pavageau, Lara
AU - Sepulveda, Pollieanna
AU - Guzman, Alicia
AU - Heyne, Elizabeth
AU - Lee, Lizette E.
AU - Vera, Azucena
AU - Waterbury, Jillian
AU - Boatman, Cathy Twell
AU - Yoder, Bradley A.
AU - Baserga, Mariana
AU - Faix, Roger G.
AU - Minton, Stephen D.
AU - Sheffield, Mark J.
AU - Rau, Carrie A.
AU - Baker, Shawna
AU - Christensen, Susan
AU - Cunningham, Sean D.
AU - Elmont, Jennifer O.
AU - Hall, Becky
AU - Jensen, Erika R.
AU - Loertscher, Manndi C.
AU - Marchant, Trisha
AU - McGrath, Kandace M.
AU - Mickelsen, Hena G.
AU - Morshedzadeh, Galina
AU - Parry, D. Melody
AU - Stout, Kelly
AU - Stuart, Ashley L.
AU - Weaver-Lewis, Kimberlee
N1 - Publisher Copyright: © 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
PY - 2023/11
Y1 - 2023/11
N2 - Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.
AB - Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.
UR - http://www.scopus.com/inward/record.url?scp=85166767123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85166767123&partnerID=8YFLogxK
U2 - 10.1038/s41372-023-01729-x
DO - 10.1038/s41372-023-01729-x
M3 - Article
C2 - 37542155
AN - SCOPUS:85166767123
SN - 0743-8346
VL - 43
SP - 1398
EP - 1405
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -