Use of Polar Picolyl Protecting Groups in Peptide Synthesis

Jose Rizo-Rey; Fernando Albericio; Guillermo Romero; Carlos García-Echeverría; Josep Claret; Carlos Muller; Ernest Giralt; Enrique Pedroso

doi:10.1021/jo00257a044

Use of Polar Picolyl Protecting Groups in Peptide Synthesis

Jose Rizo-Rey, Fernando Albericio, Guillermo Romero, Carlos García-Echeverría, Josep Claret, Carlos Muller, Ernest Giralt, Enrique Pedroso

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Protection of serine and threonine side chains with the 4-picolyl group and aspartic and glutamic acids with the 3-picolyl group is described. Picolyl-protected peptide segments are markedly more polar than benzylprotected analogues, which can facilitate their purification.

Original language	English (US)
Pages (from-to)	5386-5389
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	53
Issue number	22
DOIs	https://doi.org/10.1021/jo00257a044
State	Published - Oct 1 1988

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jo00257a044

Cite this

@article{be6d2b3c2a1645de8edd9d5c910b52d1,

title = "Use of Polar Picolyl Protecting Groups in Peptide Synthesis",

abstract = "Protection of serine and threonine side chains with the 4-picolyl group and aspartic and glutamic acids with the 3-picolyl group is described. Picolyl-protected peptide segments are markedly more polar than benzylprotected analogues, which can facilitate their purification.",

author = "Jose Rizo-Rey and Fernando Albericio and Guillermo Romero and Carlos Garc{\'i}a-Echeverr{\'i}a and Josep Claret and Carlos Muller and Ernest Giralt and Enrique Pedroso",

year = "1988",

month = oct,

day = "1",

doi = "10.1021/jo00257a044",

language = "English (US)",

volume = "53",

pages = "5386--5389",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "22",

}

TY - JOUR

T1 - Use of Polar Picolyl Protecting Groups in Peptide Synthesis

AU - Rizo-Rey, Jose

AU - Albericio, Fernando

AU - Romero, Guillermo

AU - García-Echeverría, Carlos

AU - Claret, Josep

AU - Muller, Carlos

AU - Giralt, Ernest

AU - Pedroso, Enrique

PY - 1988/10/1

Y1 - 1988/10/1

N2 - Protection of serine and threonine side chains with the 4-picolyl group and aspartic and glutamic acids with the 3-picolyl group is described. Picolyl-protected peptide segments are markedly more polar than benzylprotected analogues, which can facilitate their purification.

AB - Protection of serine and threonine side chains with the 4-picolyl group and aspartic and glutamic acids with the 3-picolyl group is described. Picolyl-protected peptide segments are markedly more polar than benzylprotected analogues, which can facilitate their purification.

UR - http://www.scopus.com/inward/record.url?scp=0008315321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0008315321&partnerID=8YFLogxK

U2 - 10.1021/jo00257a044

DO - 10.1021/jo00257a044

M3 - Article

AN - SCOPUS:0008315321

SN - 0022-3263

VL - 53

SP - 5386

EP - 5389

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 22

ER -

Use of Polar Picolyl Protecting Groups in Peptide Synthesis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this