TY - JOUR
T1 - Use of myocardial performance index in pediatric patients with idiopathic pulmonary arterial hypertension
AU - Dyer, Karrie L.
AU - Pauliks, Linda B.
AU - Das, Bibhuti
AU - Shandas, Robin
AU - Ivy, Dunbar
AU - Shaffer, Elizabeth M.
AU - Valdes-Cruz, Lilliam M.
PY - 2006/1
Y1 - 2006/1
N2 - Background: The myocardial performance index (MPI) correlates with clinical status in adults with idiopathic pulmonary arterial (PA) hypertension (IPAH). This pediatric study used MPI to assess response to bosentan therapy. Methods: The study included 12 children with IPAH and 12 healthy control subjects. MPI was correlated with catheterization data at initiation of bosentan and at a median follow-up of 9 months. Therapy responders were defined by a greater than 20% decrease in mean PA pressure. Results: Right ventricular MPI for patients with IPAH was 0.64 ± 0.30 versus 0.28 ± 0.03 in control subjects (P < .01). It had a strong correlation with mean PA pressure (R = 0.94; P < .001). Right ventricular MPI decreased significantly in responders (range 20%-44%, mean 25%) with a 5% increase in nonresponders. Conclusions: Right ventricular MPI in pediatric IPAH correlates with mean PA pressure and response to therapy. This study suggests that this noninvasive Doppler index may be useful to follow up children with IPAH, particularly when tricuspid regurgitation data are insufficient.
AB - Background: The myocardial performance index (MPI) correlates with clinical status in adults with idiopathic pulmonary arterial (PA) hypertension (IPAH). This pediatric study used MPI to assess response to bosentan therapy. Methods: The study included 12 children with IPAH and 12 healthy control subjects. MPI was correlated with catheterization data at initiation of bosentan and at a median follow-up of 9 months. Therapy responders were defined by a greater than 20% decrease in mean PA pressure. Results: Right ventricular MPI for patients with IPAH was 0.64 ± 0.30 versus 0.28 ± 0.03 in control subjects (P < .01). It had a strong correlation with mean PA pressure (R = 0.94; P < .001). Right ventricular MPI decreased significantly in responders (range 20%-44%, mean 25%) with a 5% increase in nonresponders. Conclusions: Right ventricular MPI in pediatric IPAH correlates with mean PA pressure and response to therapy. This study suggests that this noninvasive Doppler index may be useful to follow up children with IPAH, particularly when tricuspid regurgitation data are insufficient.
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U2 - 10.1016/j.echo.2005.07.010
DO - 10.1016/j.echo.2005.07.010
M3 - Article
C2 - 16423665
AN - SCOPUS:30844465248
SN - 0894-7317
VL - 19
SP - 21
EP - 27
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 1
ER -