Use of a thick-film capillary column for the analysis of organic acids in body fluids

Wolfram Meier-Augenstein; Georg F. Hoffmann; Bonnie Holmes; Jill L. Jones; William L. Nyhan; Larry Sweetman

doi:10.1016/0378-4347(93)80298-I

Use of a thick-film capillary column for the analysis of organic acids in body fluids

Wolfram Meier-Augenstein, Georg F. Hoffmann, Bonnie Holmes, Jill L. Jones, William L. Nyhan, Larry Sweetman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.

Original language	English (US)
Pages (from-to)	127-135
Number of pages	9
Journal	Journal of Chromatography B: Biomedical Sciences and Applications
Volume	615
Issue number	1
DOIs	https://doi.org/10.1016/0378-4347(93)80298-I
State	Published - May 19 1993
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1016/0378-4347(93)80298-I

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title = "Use of a thick-film capillary column for the analysis of organic acids in body fluids",

abstract = "An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.",

author = "Wolfram Meier-Augenstein and Hoffmann, {Georg F.} and Bonnie Holmes and Jones, {Jill L.} and Nyhan, {William L.} and Larry Sweetman",

note = "Funding Information: This work was financially supportedi n part by the Deutsche Forschungsgemeinschaft( Bonn, Germany), Grant No. HO 966/3-2, and by the US Public Health Service, Grant No. NS22343, to the Center for the Study of the Neurological Basis of Languagef rom the National Institute of Neurological Disorders and Stroke (Bethesda, MD, USA).",

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T1 - Use of a thick-film capillary column for the analysis of organic acids in body fluids

AU - Meier-Augenstein, Wolfram

AU - Hoffmann, Georg F.

AU - Holmes, Bonnie

AU - Jones, Jill L.

AU - Nyhan, William L.

AU - Sweetman, Larry

N1 - Funding Information: This work was financially supportedi n part by the Deutsche Forschungsgemeinschaft( Bonn, Germany), Grant No. HO 966/3-2, and by the US Public Health Service, Grant No. NS22343, to the Center for the Study of the Neurological Basis of Languagef rom the National Institute of Neurological Disorders and Stroke (Bethesda, MD, USA).

PY - 1993/5/19

Y1 - 1993/5/19

N2 - An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.

AB - An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.

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Use of a thick-film capillary column for the analysis of organic acids in body fluids

Abstract

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