TY - JOUR
T1 - Use of a thick-film capillary column for the analysis of organic acids in body fluids
AU - Meier-Augenstein, Wolfram
AU - Hoffmann, Georg F.
AU - Holmes, Bonnie
AU - Jones, Jill L.
AU - Nyhan, William L.
AU - Sweetman, Larry
N1 - Funding Information:
This work was financially supportedi n part by the Deutsche Forschungsgemeinschaft( Bonn, Germany), Grant No. HO 966/3-2, and by the US Public Health Service, Grant No. NS22343, to the Center for the Study of the Neurological Basis of Languagef rom the National Institute of Neurological Disorders and Stroke (Bethesda, MD, USA).
PY - 1993/5/19
Y1 - 1993/5/19
N2 - An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.
AB - An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 μmol/l to 500 μmol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.
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U2 - 10.1016/0378-4347(93)80298-I
DO - 10.1016/0378-4347(93)80298-I
M3 - Article
C2 - 8340451
AN - SCOPUS:0027287966
SN - 0378-4347
VL - 615
SP - 127
EP - 135
JO - Journal of Chromatography B: Biomedical Sciences and Applications
JF - Journal of Chromatography B: Biomedical Sciences and Applications
IS - 1
ER -