Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma

Georg C. Hutterer, Pierre I. Karakiewicz, Craig Zippe, Gerson Lüdecke, Hans Boman, Marta Sanchez-Carbayo, Roberto Casella, Christine Mian, Martin G. Friedrich, Sanaa Eissa, Hideyuki Akaza, Vincenzo Serretta, Hans Hedelin, Raina Rupesh, Naoto Miyanaga, Arthur I Sagalowsky, Paul Perrotte, Yair Lotan, Michael J. Marberger, Shahrokh F. Shariat

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


OBJECTIVE: To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC). PATIENTS AND METHODS: We tested the sensitivity, specificity and the predictive accuracy of NMP22 in the context of non-TCC bladder cancer recurrence, and compared it to the performance of urinary cytology. The study group comprised 2687 patients with history of non-muscle-invasive bladder cancer from 10 centres across four continents. RESULTS: The mean patient age was 64.8 years and 75.4% were men; of all patients, 513 (19.1%) had positive urinary cytology, 906 (33.7%) had a positive NMP22 test (≥10 units/mL) and 80 (3.0%) had non-TCC recurrence. Most of these, i.e. 60 (75%), were stage ≥T2. The sensitivity and specificity of urinary cytology were, respectively, 20.0% and 94.8%, vs 77.5% and 81.8% for NMP22 of ≥10 units/mL. The predictive accuracy of urinary cytology was 57.5%, vs 87.1% for NMP22 ≥ 10 units/mL. A combined model that included dichotomized NMP22 and urinary cytology was 85.3% accurate. CONCLUSION: The ability of a NMP22 level of ≥10 units/mL to predict non-TCC recurrence was better than that of urinary cytology, suggesting that NMP22 might have a role in the surveillance of patients at risk of non-TCC recurrence.

Original languageEnglish (US)
Pages (from-to)561-565
Number of pages5
JournalBJU international
Issue number5
StatePublished - Mar 2008


  • Bladder cancer
  • Disease recurrence
  • NMP22
  • Prediction
  • Squamous cell carcinoma
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Urology


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