Uric Acid Nephrolithiasis

Mary Ann Cameron, Khashayar Sakhaee

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria. Insulin resistance may contribute to the development of acidic urine by augmenting endogenous acid production and decreasing renal ammonium excretion. Medical management strategies focus primarily on alkali treatment or decreasing hyperuricosuria.

Original languageEnglish (US)
Pages (from-to)335-346
Number of pages12
JournalUrologic Clinics of North America
Issue number3
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Urology


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