Uric Acid Nephrolithiasis

Mary Ann Cameron; Khashayar Sakhaee

doi:10.1016/j.ucl.2007.05.001

Uric Acid Nephrolithiasis

Mary Ann Cameron, Khashayar Sakhaee

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria. Insulin resistance may contribute to the development of acidic urine by augmenting endogenous acid production and decreasing renal ammonium excretion. Medical management strategies focus primarily on alkali treatment or decreasing hyperuricosuria.

Original language	English (US)
Pages (from-to)	335-346
Number of pages	12
Journal	Urologic Clinics of North America
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.ucl.2007.05.001
State	Published - Aug 2007

ASJC Scopus subject areas

Urology

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10.1016/j.ucl.2007.05.001

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title = "Uric Acid Nephrolithiasis",

abstract = "Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria. Insulin resistance may contribute to the development of acidic urine by augmenting endogenous acid production and decreasing renal ammonium excretion. Medical management strategies focus primarily on alkali treatment or decreasing hyperuricosuria.",

author = "Cameron, {Mary Ann} and Khashayar Sakhaee",

note = "Funding Information: The authors are supported by the National Institutes of Health (P01-DK20543, M01-RR00633) and the National Kidney Foundation. ",

year = "2007",

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AU - Cameron, Mary Ann

AU - Sakhaee, Khashayar

N1 - Funding Information: The authors are supported by the National Institutes of Health (P01-DK20543, M01-RR00633) and the National Kidney Foundation.

PY - 2007/8

Y1 - 2007/8

N2 - Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria. Insulin resistance may contribute to the development of acidic urine by augmenting endogenous acid production and decreasing renal ammonium excretion. Medical management strategies focus primarily on alkali treatment or decreasing hyperuricosuria.

AB - Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria. Insulin resistance may contribute to the development of acidic urine by augmenting endogenous acid production and decreasing renal ammonium excretion. Medical management strategies focus primarily on alkali treatment or decreasing hyperuricosuria.

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JO - Urologic Clinics of North America

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Uric Acid Nephrolithiasis

Abstract

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