@article{18a0dc41f69f48bb97ab3e96e56c1d2c,
title = "Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy",
abstract = "We analyzed quantitative maps of T1 and T2 relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age-range-matched healthy volunteer boys. The cardiac-optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy.",
author = "Lasya Gaur and Alexander Hanna and Bandettini, {W. Patricia} and Fischbeck, {Kenneth H.} and Arai, {Andrew E.} and Ami Mankodi",
note = "Funding Information: The study was supported by NINDS intramural research funds. The authors thank the study participants and their families; Donovan Stock, Elizabeth Hartnett, and Alice Schindler (NINDS) for help with coordinating study visits and scheduling MRI studies; Hirity Shimellis for assistance with database audit, Christine Mancini and Laura Olivieri, and Sujata Shanbhag (NHLBI) for help with acquiring MRI data; and the Principal Investigators of the referring sites participating in the DMD114876 trial (Barry Russman, Portland, OR; Benjamin Renfroe, Gulf Breeze, FL; Brenda Wong, Cincinnati, OH; Douglas Sproule, New York, NY; Edward Smith, Durham, NC; and Kathryn Wagner, Baltimore, MD) for sharing study participants. We also thank GlaxoSmithKline and Prosensa/BioMarin, study sponsors of the DMD114876 trial, for sharing the echocardiography data. Publisher Copyright: Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association",
year = "2016",
month = dec,
day = "1",
doi = "10.1002/acn3.367",
language = "English (US)",
volume = "3",
pages = "948--955",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
publisher = "John Wiley and Sons Inc.",
number = "12",
}