Updates in molecular genetics of therapy-related myeloid neoplasms

Miguel Dario Cantu

doi:10.1053/j.semdp.2023.04.001

Updates in molecular genetics of therapy-related myeloid neoplasms

Research output: Contribution to journal › Review article › peer-review

Abstract

Therapy-related myeloid neoplasms (t-MN) are a heterogeneous group of aggressive myeloid neoplasms that arise following exposure to various cytotoxic therapeutic agents and/or ionizing radiation for treatment of prior non-myeloid malignancy or autoimmune disease. Each therapeutic group has been associated with varying latency intervals from the time of therapy exposure to onset of t-MN, as well as certain recurrent genetic alterations.

Original language	English (US)
Pages (from-to)	182-186
Number of pages	5
Journal	Seminars in Diagnostic Pathology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1053/j.semdp.2023.04.001
State	Published - May 2023

Keywords

Acute myeloid leukemia
Complex karyotype
Cytotoxic chemotherapy
Ionizing radiation
Monosomal karyotype
Myelodysplastic syndrome
Secondary AML
Therapy-related myeloid neoplasms

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1053/j.semdp.2023.04.001

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title = "Updates in molecular genetics of therapy-related myeloid neoplasms",

abstract = "Therapy-related myeloid neoplasms (t-MN) are a heterogeneous group of aggressive myeloid neoplasms that arise following exposure to various cytotoxic therapeutic agents and/or ionizing radiation for treatment of prior non-myeloid malignancy or autoimmune disease. Each therapeutic group has been associated with varying latency intervals from the time of therapy exposure to onset of t-MN, as well as certain recurrent genetic alterations.",

keywords = "Acute myeloid leukemia, Complex karyotype, Cytotoxic chemotherapy, Ionizing radiation, Monosomal karyotype, Myelodysplastic syndrome, Secondary AML, Therapy-related myeloid neoplasms",

author = "Cantu, {Miguel Dario}",

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year = "2023",

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AB - Therapy-related myeloid neoplasms (t-MN) are a heterogeneous group of aggressive myeloid neoplasms that arise following exposure to various cytotoxic therapeutic agents and/or ionizing radiation for treatment of prior non-myeloid malignancy or autoimmune disease. Each therapeutic group has been associated with varying latency intervals from the time of therapy exposure to onset of t-MN, as well as certain recurrent genetic alterations.

KW - Acute myeloid leukemia

KW - Complex karyotype

KW - Cytotoxic chemotherapy

KW - Ionizing radiation

KW - Monosomal karyotype

KW - Myelodysplastic syndrome

KW - Secondary AML

KW - Therapy-related myeloid neoplasms

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Updates in molecular genetics of therapy-related myeloid neoplasms

Abstract

Keywords

ASJC Scopus subject areas

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