TY - JOUR
T1 - Uniqueness of the mechanism of protein import into the peroxisome matrix
T2 - Transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors
AU - Léon, Sébastien
AU - Goodman, Joel M.
AU - Subramani, Suresh
PY - 2006/12
Y1 - 2006/12
N2 - Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that later lost their DNA, it was expected that protein transport into this organelle would have parallels to systems found in other organelles of endosymbiont origin, such as mitochondria and chloroplasts. This review highlights three features of peroxisomal matrix protein import that make it unique in comparison with these other subcellular compartments - the ability of this organelle to transport folded, co-factor-bound and oligomeric proteins, the dynamics of the import receptors during the matrix protein import cycle and the existence of a peroxisomal quality-control pathway, which insures that the peroxisome membrane is cleared of cargo-free receptors.
AB - Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that later lost their DNA, it was expected that protein transport into this organelle would have parallels to systems found in other organelles of endosymbiont origin, such as mitochondria and chloroplasts. This review highlights three features of peroxisomal matrix protein import that make it unique in comparison with these other subcellular compartments - the ability of this organelle to transport folded, co-factor-bound and oligomeric proteins, the dynamics of the import receptors during the matrix protein import cycle and the existence of a peroxisomal quality-control pathway, which insures that the peroxisome membrane is cleared of cargo-free receptors.
KW - Extended shuttle
KW - Import of folded and oligomeric protein
KW - Peroxisomal RADAR
KW - Peroxisomal matrix protein import
KW - Quality-control
KW - Shuttling receptor
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U2 - 10.1016/j.bbamcr.2006.08.037
DO - 10.1016/j.bbamcr.2006.08.037
M3 - Review article
C2 - 17011644
AN - SCOPUS:33845318489
SN - 0167-4889
VL - 1763
SP - 1552
EP - 1564
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 12
ER -