Type III Effector VopC Mediates Invasion for Vibrio Species

Lingling Zhang, Anne Marie Krachler, Christopher A. Broberg, Yan Li, Hamid Mirzael, Christopher J. Gilpin, Kim Orth

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Vibrio spp. are associated with infections caused by contaminated food and water. A type III secretion system (T3SS2) is a shared feature of all clinical isolates of . V. parahaemolyticus and some . V. cholerae strains. Despite its being responsible for enterotoxicity, no molecular mechanism has been determined for the T3SS2-dependent pathogenicity. Here, we show that although . Vibrio spp. are typically thought of as extracellular pathogens, the T3SS2 of . Vibrio mediates host cell invasion, vacuole formation, and replication of intracellular bacteria. The catalytically active effector VopC is critical for . Vibrio T3SS2-mediated invasion. There are other marine bacteria encoding VopC homologs associated with a T3SS; therefore, we predict that these bacteria are also likely to use T3SS-mediated invasion as part of their pathogenesis mechanisms. These findings suggest a new molecular paradigm for . Vibrio pathogenicity and modify our view of the roles of T3SS effectors that are translocated during infection.

Original languageEnglish (US)
Pages (from-to)453-460
Number of pages8
JournalCell Reports
Issue number5
StatePublished - May 31 2012

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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