Two steps, one ligand: How PPARγ binds small-molecule agonists

James J. Siclari, Kevin H. Gardner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In this issue of Structure, Shang and Kojetin (2021) present insights into the binding mechanism of artificial agonists to the PPARγ nuclear receptor. These data support a two-step model with induced fit and conformational selection aspects. This mechanism may exist in related receptors, providing new opportunities for drug development.

Original languageEnglish (US)
Pages (from-to)935-936
Number of pages2
Issue number9
StatePublished - Sep 2 2021
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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